Abstract:Recent studies have indicated that transcription and translation are more pervasive on a genome-wide level than previously thought (Xu et al., 2009, Nature 457: 1033; Ingolia et al., 2009 Science 324:218). Specifically, studies using ribosome profiling have shown evidence of translation at previously un-annotated open reading frames (ORFs). These findings challenge current approaches to genome annotation. As a result, new methods are being developed in order to more precisely visualize the proteome. One method… Show more
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