Assessment of the accuracy of serial electrocardiograms in the diagnosis of myocardial infarction

McQueen, Matthew; Holder, Douglas; El-Maraghi, N. R. H.

doi:10.1016/0002-8703(83)90524-0

Cited by 83 publications

(25 citation statements)

References 22 publications

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“…Twenty five subjects were selected from normal blood donors and another 25 subjects with polytraumatic injury without any chest or cardiac ailment were also included in the study to serve as controls. Well standardised methods were used for the estimation of CK, CKMB, SGOT, o~HBDH and Troponin T (1)(2)(3)(4)(5), The serum Cardiac Troponin T concentration was measured using the reagent kit manufactured by Boehringer Mannheim based on enzyme linked immunoassay.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of clinical utility of serum enzymes and troponin—T in the early stages of acute myocardial infarction

Shah¹,

Haridas

2003

Indian J Clin Biochem

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Laboratory infarction diagnostics are based on the detection of elevated serum activities of total Creatine Kinase (CK), Creatine Kinase isoensyme MB,(CKMB), Lactate dehydrogenase (LDH), isoenzyme forms of LDH and transaminases. Determination of these cardiac marker enzymes permits a highly sensitive diagnosis of transmural myocardial infarction. In such patients the diagnosis of acute myocardial infarction can be confirmed by the clinical symptoms, and changes in the ECG in addition to the enzyme assays. The 50 AMI patients selected in the present study were those admitted to the ICCU of Shri Krishna Hospital, Karamsad. The blood samples were taken at the time of admission (ie. within four hours of the start of chest pain). The samples were analyzed for CK, CKMB, SGOT,(Serum glutamate oxaloactate transaminase) (~HBDH o~ -hydroxybutyrate dehydrogenase and troponin T. The serum CKMB activity in AMI showed an increase only 5-6 hours after the commencement of chest pain. The elevation in SGOT and ocHBDH was still delayed. At the same time we could observe that the cardiac Troponin T (cTnT) was elevated at the time of admission of the patient itself. This increase of cTnT in AMI patients was 20 times higher than the normal blood donors. The controls included 25 normal blood donors and 25 patients with polytraumatic injuries with no chest contusion. The study shows that cTnT estimation could serve in the early diagnosis of AMI. The increase of cardiac troponin T in AMI patient was 20 times higher than the normal blood donors in AMI patients at the time of admission. Cardiac troponin T in serum appears to be a more sensitive indicator of myocardial cell injury than CKMB activity and its detection in the circulation may be a useful prognostic indicator in patients with unstable angina as well. When the blood of normal blood donors or that of patients with polytraumatic injury was analysed the troponin T values were well within the normal range in both the above categories showing that cardiac troponin T is highly specific for heart tissue .Although CKMB and cardiac troponin T are released soon after the myocardial injury, the release of cardiac troponin T is much earlier than CKMB thereby invalidating the important role of cardiac troponin T in diagnosing AMI. Cardiactroponin T has been shown to be highly sensitive for cardiac injury and not elevated in any other trauma, heavy exercise or skeletal muscle injury.Cardiac troponin T is ordinarily undetectable in healthy individuals, and so its measurement can serve as a powerful tool in the diagnosis of AMl. KEY WORDSCardiac Troponin T, alpha hydroxybutyrate dehydrogenase, Lactate dehydrogenase, myocardial infarction

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Section: Methodsmentioning

confidence: 99%

Evaluation of clinical utility of serum enzymes and troponin—T in the early stages of acute myocardial infarction

Shah¹,

Haridas

2003

Indian J Clin Biochem

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“…These sera were used for the estimation of CK, CKMB, SGOT, DHBDH and Troponin T on RA -50 semi auto analyzer by well standardized methods (1)(2)(3)(4)(5). The CTnT was estimated by the reagent kit manufactured by Boehringer based on ELISA.…”

Section: Methodsmentioning

confidence: 99%

A serial follow up study of cardiac marker enzymes during the week after acute myocardial infarction

Shah

Haridas

2007

Indian J Clin Biochem

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“…MB is an early and sensitive marker of cardiac cell damage but lacks specificity. [7] CKMB begins to increase between 3 and 5 h after the onset of myocardial infarction. [8] CK-MB though more specific for cardiac injury, lacks early sensitivity.…”

Section: Introductionmentioning

confidence: 97%

Comparative status of glycogen phosphorylase BB, myoglobin, and CK-MB for early diagnosis of acute myocardial infarction

Rathore¹,

Rastogi²,

Chandel³

et al. 2017

Int J Med Sci Public Health

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Assessment of the accuracy of serial electrocardiograms in the diagnosis of myocardial infarction

Cited by 83 publications

References 22 publications

Evaluation of clinical utility of serum enzymes and troponin—T in the early stages of acute myocardial infarction

Evaluation of clinical utility of serum enzymes and troponin—T in the early stages of acute myocardial infarction

A serial follow up study of cardiac marker enzymes during the week after acute myocardial infarction

Comparative status of glycogen phosphorylase BB, myoglobin, and CK-MB for early diagnosis of acute myocardial infarction

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