Assessment of Renal Function

Hart, Susan Emeigh

doi:10.1007/978-3-642-27728-3_18-1

Cited by 1 publication

(1 citation statement)

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“…Moreover, the proximal tubule epithelium is more vulnerable to nephrotoxicity, as confirmed in this study. This specific local affection can be attributed to the fact that these cells express various transporters, which enable active intake and intracellular accumulation of toxic compounds [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Supplementation with Filipendula ulmaria Extract Attenuates the Systemic Adverse Effects of Nanosized Calcium Phosphates in Rats

Šćepanović

Selaković

Stanković

et al. 2021

Oxidative Medicine and Cellular Longevity

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The aim of this study was to investigate and compare the systemic toxicity of three nanosized calcium phosphates (CaPs): hydroxyapatite (HA), tricalcium phosphate (TCP), and amorphous calcium phosphate (ACP) in rats. Since those metallic compounds are widely used as bone replacement materials, including their use in oral surgery, CaPs were applied (per os) equimollary (17.8 mg/kg, 11 mg/kg, and 9.65 mg/kg b.w., respectively) for 30 days in order to mimic the previously described release rate from dental composites. Also, we employed antioxidant supplementation with Filipendula ulmaria (FU) extract. All the applied CaPs significantly increased serum calcium, triglycerides, LDL, and LDH, while serum levels of testosterone and LH declined, with no alterations in the liver enzymes. The evaluation of oxidative stress markers (in the liver, kidney, and testicle) showed an increase in TBARS values, while SOD and CAT activities and GSH levels were significantly reduced. The relative gene expression of Bax and Bcl-2 was shifted to proapoptotic action, accompanied by intense characteristic histological changes in architecture in all investigated organs. The toxic effects were most prominent in groups treated by ACP. FU administration attenuated the majority of nanosized CaP-induced adverse effects, thus recommending this therapeutic approach to minimize nano-CaP systemic toxicities.

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Section: Discussionmentioning

confidence: 99%