Assessment of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma

Tazeen, Sanah; Prasad, Kavitha; Harish, K; Sagar, Parimala; Kapali, Aravind S; Satish, Chetan

doi:10.1016/j.joms.2020.01.001

Cited by 23 publications

(33 citation statements)

References 26 publications

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“…In the present study, we found NLR as one of the important prognostic factors for LRR and OS. Our findings matched with other studies (19,20) (23). Ninety-two patients with locally advanced oropharyngeal cancer with a median follow-up was 39 months.…”

Section: Discussionsupporting

confidence: 92%

Role of systemic inflammatory markers (biomarkers) as important prognostic factors for survival in head and neck cancer

Maiti

Singh

Bose³

et al. 2021

Biomedicine

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Introduction and Aim: Cancer related inflammation is recognized as a critical multifaceted player in tumour initiation and progression. The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are important markers of systemic inflammatory burden in malignancy. The present retrospective study aimed to evaluate the prognostic value of pre-treatment baseline (NLR) and (PLR) for survival in HNC patients. Materials and Methods: Analysis of data of 257 patients with head and neck cancer treated with definitive therapy over 3.5 yrs. Neutrophil, lymphocyte and platelet counts before treatment of all patients were collected and NLR and PLR were calculated. Results: Median value of NLR and PLR were 3.7 and 170.63 respectively. Receiver operator characteristics (ROC) curve analysis showed the predictive cut-off value of NLR and PLR as 3.9 and 158.3. Univariate analysis using Cox-regression model showed NLR (p < 0.001) and PLR (p = 0.001) significantly influenced the locoregional recurrence free survival (LRRFS) and overall survival (OS). The multivariate analysis showed NLR is the independent prognostic factors influencing LRRFS (p = 0.007) and OS (p = 0.002). Kaplan-Meier survival curve (Log rank test; Chi-square (?2) value) showed OS is significantly influenced by NLR group (LRRFS; ?2 = 23.9 and OS; ?2 = 33.7) and PLR group (LRRFS; ?2 = 11.2 and OS; ?2 = 19.3) in contrast to LRRFS. Conclusion: NLR can be strongly used as biomarker for prognostication for outcome and survival in head neck cancer. However, a well-designed, larger studies with longer follow-up is warranted.

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Section: Discussionsupporting

confidence: 92%

Role of systemic inflammatory markers (biomarkers) as important prognostic factors for survival in head and neck cancer

Maiti

Singh

Bose³

et al. 2021

Biomedicine

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“…All the included studies were published between 2013 and 2020 with sample sizes ranging from 59 to 708. Twenty‐five studies 18–32,34–40,42–44 were conducted in Asia, one 33 in North America and one 41 in Europe (Table 1). Twenty‐three 18–24,27–31,33,34,36–44 studies included patients with TNM stages I‐II and III‐IV, three studies 25,26,32 included only patients in the stages III‐IV and one study 24 included exclusively patients in stages I‐II.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-five studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][34][35][36][37][38][39][40][42][43][44] were conducted in Asia, one 33 in North America and one 41 in Europe (Table 1). Twenty-three [18][19][20][21][22][23][24][27][28][29][30][31]33,34,[36][37][38][39][40][41][42][43][44] studies included patients with TNM stages I-II and III-IV, three studies …”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Pre‐treatment neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in head and neck squamous cell carcinoma: Meta‐analysis and trial sequential analysis

Mariani

Russo

Maisto

et al. 2021

J Oral Pathology Medicine

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, with 890 000 new cases and 450 000 deaths in 2018 worldwide. 1 Despite improvements in research and therapy made in the last decades, survival has not significantly improved and the 5 years overall survival (OS) rate is still less than 50%. 2 Classic prognostic factors are not sufficient to predict patients' prognosis, due to the heterogeneity of molecular mechanisms and tumour behaviours related to HNSCC. For these reasons, there has been an intensified interest in biomarkers' discovery for early diagnosis, prognosis and personalized treatment.In this scenario, inflammatory biomarkers became a reliable and accessible source of information to investigate and correlate to

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“…Neutrophils are the first line of defense of the body which can increase rapidly when body gets acute infection, various poisoning and the damage of tissue. Now, a lot of growing research has suggested the positive role of neutrophils in the growth of tumor (22)(23)(24). Neutrophils are major inflammatory constituents of TME, which can facilitate the growth and development of tumor by different mechanisms (24,25).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-Lymphocyte Ratio and Circulating Tumor Cells Counts Predict Prognosis in Gastrointestinal Cancer Patients

et al. 2021

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PurposeThe purpose of this study is to explore the prognostic value of associating pre-treatment neutrophil–lymphocyte ratio (NLR) with circulating tumor cells counts (CTCs) in patients with gastrointestinal cancer.Materials and MethodsWe collected the related data of 72 patients with gastric cancer (GC) and colorectal cancer (CRC) who received different therapies from August 2016 to October 2020, including age, gender, primary tumor location, TNM stage, tumor-differentiation, NLR, CTCs, disease-free survival (DFS) and overall survival (OS). We chose the optimal cut-off value of NLR >3.21 or NLR ≤3.21 and CTC >1 or CTC ≤1 by obtaining receiver operating characteristic (ROC) curve. The Kaplan–Meier survival analysis and Cox regression analysis were used to analyze DFS and OS. To clarify the role of the combination of NLR and CTCs counts in predicting the prognosis, we analyzed the DFS and OS when associated NLR and CTCs counts.ResultsA high NLR (>3.21) was associated with shorter DFS (P <0.0001) and OS (P <0.0001). Patients with high CTCs level (>1) had shorter DFS (P = 0.001) and OS (P = 0.0007) than patients with low CTCs level. Furthermore, patients who had both higher NLR and higher CTCs counts had obvious shorter DFS (P <0.0001) and OS (P <0.0001).ConclusionsPatients with higher NLR and more CTCs respectively tended to have poor prognosis with shorter DFS and OS, which might be regarded as predictors of gastrointestinal cancer. In particular, associating NLR and CTCs counts might be a reliable predictor in patients with gastrointestinal cancer.

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Assessment of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma

Cited by 23 publications

References 26 publications

Role of systemic inflammatory markers (biomarkers) as important prognostic factors for survival in head and neck cancer

Role of systemic inflammatory markers (biomarkers) as important prognostic factors for survival in head and neck cancer

Pre‐treatment neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in head and neck squamous cell carcinoma: Meta‐analysis and trial sequential analysis

Neutrophil-Lymphocyte Ratio and Circulating Tumor Cells Counts Predict Prognosis in Gastrointestinal Cancer Patients

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