Assessment of Montelukast, Doxofylline, and Tiotropium With Budesonide for the Treatment of Asthma: Which Is the Best Among the Second-line Treatment? A Randomized Trial

Rajanandh, Muhasaparur Ganesan; Nageswari, A.D.; Ilango, K.

doi:10.1016/j.clinthera.2014.12.008

Cited by 31 publications

(22 citation statements)

References 19 publications

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“…The study of Rajanandh and coworkers aimed to compare the 6 month efficacy and safety of formoterol (12 mcg), montelukast (10 mg), doxofylline (400 mg), or tiotropium (18 mcg) in combination with a low-dose budesonide (400 mcg) in patients with mild to moderate persistent asthma [ 27 ]. Outcomes included FEV1, Saint George Respiratory Questionnaire (SGRQ) scores, asthma symptom scores (daytime and night time), assessment of tolerability and rescue medication use.…”

Section: Resultsmentioning

confidence: 99%

Tiotropium in asthma: back to the future of anticholinergic treatment

Bonini

Scichilone

2017

Clin Mol Allergy

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Asthma is among the most common chronic diseases worldwide; however, despite progresses in the understanding of the patho-physiological mechanisms and advances in the development of new therapeutic options and strategies, the disease remains uncontrolled in a not trivial proportion of subjects. Thus, the need of new molecules to treat the underlying biological and functional abnormalities and to control symptoms is strongly advocated by clinicians. In this scenario, the most recent GINA guidelines have included the use of tiotropium bromide in the most severe and uncontrolled forms of the disease, in addition to treatment with inhaled corticosteroid plus long acting beta adrenergic agents. Indeed, a large body of evidence has accumulated to support the use of tiotropium bromide in asthma. The current review paper provides a state of the art systematic revision of findings on the efficacy and safety of tiotropium in the adult and paediatric asthma population. To this aim, electronic searches were undertaken in the most common scientific databases from the date of inception to March 2017. Robust and high quality evidence showed that tiotropium is effective and safe in both adults and children/adolescents. Predictive markers of response have been also suggested, as well as cost–benefit analyses reported. The tiotropium bronchodilator effect seems to be not solely related to the reduction of the smooth muscle tone. However, the observations on anti-inflammatory properties or reduction in mucus production, despite highly interesting, have been only demonstrated in in vitro studies and animal models, therefore advocating for further specifically designed investigations.

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Section: Resultsmentioning

confidence: 99%

Tiotropium in asthma: back to the future of anticholinergic treatment

Bonini

Scichilone

2017

Clin Mol Allergy

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“…These cells release mediators such as chemokine, cysteinyl leukotrienes, cytokines, histamine, nitric oxide and prostaglandin D-2 (PGD 2 ), which contribute to the symptoms of asthma. Inflammatory mediators were also produced by structural cells of the airways and they contribute to the perseverance of inflammation in other ways (Rajanandh et al, 2015).…”

Section: Pathophysiologymentioning

confidence: 99%

“…The p38 MAP kinase inhibitors such as SB203580 and RWJ67657 inhibit the synthesis of many inflammatory cytokines and chemokines and therefore, they are in the process of development for the treatment of asthma and COPD (Rajanandh et al, 2015).…”

Section: Newer Anti-inflammatory Drugsmentioning

confidence: 99%

An Overview and Update on Asthma and its Management

Rajanandh¹

2015

J. of Medical Sciences

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“…The objectives of the asthma treatment are not fulfilled completely with only inhaled corticosteroid (ICS). For this reason, without increasing the dose of ICS, the addition of a second drug with complementary mechanism is preferred [3][4][5].…”

Section: Introductionmentioning

confidence: 99%