2020
DOI: 10.3390/nu12010186
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Abstract: Malnutrition is a common comorbidity in patients with cirrhosis. Its prognostic value is indisputable as it greatly affects the evolution of liver diseases. It has a major impact on both morbi-mortality before and after liver transplantation. Being now integrated in the definition of malnutrition and recognized as a new entity in the international classification of diseases, physicians have taken great interest in sarcopenia. Its negative consequences on the fate of patients with cirrhosis are well-demonstrate… Show more

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Cited by 74 publications
(61 citation statements)
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References 118 publications
(173 reference statements)
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“…Our data are in line with previous studies demonstrating an association of sarcopenia and an impaired prognosis in patients with nonalcoholic liver disease ( 18 ), liver cirrhosis ( 19 ), cardiovascular ( 20 ), and lung diseases ( 21 ). Furthermore, it was demonstrated that sarcopenia might predict outcome of patients undergoing therapeutic interventions such as transcatheter arterial chemoembolization (TACE) ( 22 ), liver transplantation ( 23 ), or colorectal cancer surgery ( 24 ).…”
Section: Discussionsupporting
confidence: 93%
“…Our data are in line with previous studies demonstrating an association of sarcopenia and an impaired prognosis in patients with nonalcoholic liver disease ( 18 ), liver cirrhosis ( 19 ), cardiovascular ( 20 ), and lung diseases ( 21 ). Furthermore, it was demonstrated that sarcopenia might predict outcome of patients undergoing therapeutic interventions such as transcatheter arterial chemoembolization (TACE) ( 22 ), liver transplantation ( 23 ), or colorectal cancer surgery ( 24 ).…”
Section: Discussionsupporting
confidence: 93%
“…As mentioned earlier, the concept of frailty has recently been extended to CLD patients. Any chronic organ dysfunction can result in physiological vulnerability [33]. However, there have been several unsolved problems regarding frailty in CLDs.…”
Section: Discussionmentioning
confidence: 99%
“…While sarcopenia was associated with a WS decline and a low physical activity, it was not associated with fatigue or BW loss. Sarcopenia in CLDs is indeed similar to physical frailty (41). Sarcopenia may be the dominant driver of the physical frailty phenotype, especially in LC patients where hepatic synthetic impairment may accelerate the skeletal muscle mass decrease (14,42,43).…”
Section: Discussionmentioning
confidence: 90%