Assessment of internal exposure to 131I and short-lived radioiodine isotopes and associated uncertainties in the Ukrainian cohort of persons exposed in utero

Masiuk, Sergii; Chepurny, Mykola; Buderatska, Valentyna; Иванова, Ольга Михайловна; Boiko, Zulfira; Zhadan, Natalia; Hatch, Maureen; Cahoon, Elizabeth K.; Zamotayeva, Galyna; Shpak, Victor; Тronko, М.D.; Drozdovitch, Vladimir

doi:10.1093/jrr/rrac007

Cited by 3 publications

(8 citation statements)

References 33 publications

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“…The same approach was used to calculate measurement-based thyroid doses from 131 I for the Belarusian and Ukrainian cohorts of persons exposed in utero whose mothers were measured for 131 I thyroid activity ( 15, 26 ). For the cohorts' members whose mothers were not measured, only model-based doses were calculated.…”

Section: Considered Studiesmentioning

confidence: 99%

“…General scheme for assessing inherent uncertainties. To assess the inherent uncertainties in the thyroid doses from 131 I received by individuals included in the Belarusian-American cohort ( 13 ), Ukrainian-American cohort ( 14 ) and Ukrainian cohort of person exposed in utero ( 15 ), 1,000 sets of cohort thyroid doses, considering classification of errors as systematic shared or random unshared, were calculated. For a specific dose realization some of the uncertain model parameter values exhibited systematic error.…”

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

“…The largest uncertainty in doses for the CTB was due to the lack of measured 131 I thyroid activity and detailed questionnaire data for around 90% of study subjects ( 28 ). For the Ukrainian cohort of persons exposed in utero, the large uncertainty was caused by (i) the uncertainty in the fetal thyroid dose coefficient-values, which were estimated from rather limited human data on the iodine uptake by the fetal thyroid gland, and (ii) the gestational age ATA, which was not exactly known ( 15 ). Table 2 demonstrates that shared errors lead to a larger range of the cohort mean doses than unshared errors.…”

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

“…Although the inherent uncertainties accounted for the uncertainties associated with questionnaire data by imputation of imprecise or missed responses ( 13–15 ), there are specific considerations regarding the quality and reliability of questionnaire data, which are described in the next section.…”

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

“…For the studies where measurement-based doses were estimated ( 13, 14 ), the contribution of shared errors to dose uncertainty was small (Table 2). In opposite, uncertainties in model-based doses were driven by shared errors in the parameters of the dose reconstruction model ( 14, 15, 50 ). If the shared parameter was a linear factor in the dosimetry model, then the deviation of the shared parameter from its mean value (mathematical expectation) led to the same deviation within the specific cohort dose realization.…”

Section: Impact Of Dosimetry Errors On Risk Analysismentioning

confidence: 99%

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Assessment of Uncertainties and Errors in Post-Chernobyl Dosimetry

et al. 2023

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The present paper reviews the uncertainties and errors in complex dosimetry systems that were developed to estimate individual doses in different post-Chernobyl (Chornobyl) radiation epidemiology studies among the general population and the cleanup workers. These uncertainties and errors are associated with (i) instrumental radiation measurements of humans and environmental samples, (ii) inherent uncertainties arising from the stochastic random variability of the parameters used in exposure assessment and from a lack of knowledge about the true values of the parameters, and (iii) human factor uncertainties due to poor memory recall resulting in incomplete, inaccurate, or missing responses during personal interview with study subjects conducted long after exposure. Relative measurement errors of 131I thyroid activity associated with devices for measuring radioactivity in the thyroid reached up to 0.86 (coefficient of variation). The inherent uncertainty in estimates of individual doses varied between different studies and exposure pathways (GSD from 1.2 to 15 for model-based doses and from 1.3 to 5.1 for measurement-based doses). The human factor uncertainties can cause individual doses to be underestimated or overestimated by an average of 10 times for model-based doses and 2 times for measurement-based doses calculated for the general population and up to 3 times for doses calculated for cleanup workers. The sources of errors and uncertainties, especially the human factor uncertainties, should be carefully considered in dose assessment for radiation epidemiological studies, with particular attention to studies involving persons without instrumental radiation measurements.

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Section: Considered Studiesmentioning

confidence: 99%

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

Section: Categories Of Errors and Uncertaintiesmentioning

confidence: 99%

Section: Impact Of Dosimetry Errors On Risk Analysismentioning

confidence: 99%

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Assessment of Uncertainties and Errors in Post-Chernobyl Dosimetry

et al. 2023

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Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident

Morton,

Lee,

Karyadi

et al. 2024

Nat Commun

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Childhood radioactive iodine exposure from the Chornobyl accident increased papillary thyroid carcinoma (PTC) risk. While cervical lymph node metastases (cLNM) are well-recognized in pediatric PTC, the PTC metastatic process and potential radiation association are poorly understood. Here, we analyze cLNM occurrence among 428 PTC with genomic landscape analyses and known drivers (131I-exposed = 349, unexposed = 79; mean age = 27.9 years). We show that cLNM are more frequent in PTC with fusion (55%) versus mutation (30%) drivers, although the proportion varies by specific driver gene (RET-fusion = 71%, BRAF-mutation = 38%, RAS-mutation = 5%). cLNM frequency is not associated with other characteristics, including radiation dose. cLNM molecular profiling (N = 47) demonstrates 100% driver concordance with matched primary PTCs and highly concordant mutational spectra. Transcriptome analysis reveals 17 differentially expressed genes, particularly in the HOXC cluster and BRINP3; the strongest differentially expressed microRNA also is near HOXC10. Our findings underscore the critical role of driver alterations and provide promising candidates for elucidating the biological underpinnings of PTC cLNM.

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Exposure to the Thyroid from Intake of Radioiodine Isotopes after the Chornobyl Accident. Report I: Revised Doses and Associated Uncertainties for the Ukrainian-American Cohort

et al. 2022

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Thyroid doses from intake of radioiodine isotopes (131I, 132Te+132I, and 133I) and associated uncertainties were revised for the 13,204 Ukrainian-American cohort members exposed in childhood and adolescence to fallout from the Chornobyl nuclear power plant accident. The main changes related to the revision of the 131I thyroid activity measured in cohort members, the use of thyroid-mass values specific to the Ukrainian population, and the revision of the 131I ground deposition densities in Ukraine. Uncertainties in doses were assessed considering shared and unshared errors in the parameters of the dosimetry model. Using a Monte-Carlo simulation procedure, 1,000 individual stochastic thyroid doses were calculated for each cohort member. The arithmetic mean of thyroid doses from intake of 131I, 132Te+132I, and 133I for the entire cohort was 0.60 Gy (median = 0.22 Gy). For 9,474 subjects (71.6% of the total), the thyroid doses were less than 0.5 Gy. Thyroid doses for 42 cohort members (0.3% of the total) exceeded 10 Gy while the highest dose was 35 Gy. Intake of 131I contributed around 95% to internal thyroid exposure from radioiodine isotopes. The geometric standard deviation of individual stochastic thyroid doses varied among cohort members from 1.4 to 4.3 with an arithmetic mean of 1.6 and a median of 1.4. It was shown that the contribution of shared errors to the dose uncertainty was small. The revised thyroid doses resulted, in average, in around 40% decrease for cohort members from Zhytomyr Oblast and an increase of around 24% and 35% for the cohort members from Kyiv and Chernihiv Oblast, respectively. Arithmetic mean of TD20 doses for the cohort was around 8% less than that estimated in TD10, 0.60 Gy vs. 0.65 Gy, respectively; however, global median of TD20 doses somewhat increased compared to TD10: 0.22 Gy vs. 0.19 Gy, respectively. The difference between TD10 and TD20 was mainly due to a revision of the individual 131I thyroid activity measured in the cohort members.

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Assessment of internal exposure to 131I and short-lived radioiodine isotopes and associated uncertainties in the Ukrainian cohort of persons exposed in utero

Cited by 3 publications

References 33 publications

Assessment of Uncertainties and Errors in Post-Chernobyl Dosimetry

Assessment of Uncertainties and Errors in Post-Chernobyl Dosimetry

Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident

Exposure to the Thyroid from Intake of Radioiodine Isotopes after the Chornobyl Accident. Report I: Revised Doses and Associated Uncertainties for the Ukrainian-American Cohort

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