2014
DOI: 10.1007/s10616-014-9744-x View full text |Buy / Rent full text
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Abstract: Behcet's disease (BD) is a multisystemic chronic inflammatory disorder that presents throughout the world with high frequency in Turkey and Middle East. BD has been shown to be associated with genotoxicity as patients with the disease have demonstrated high rates of sister chromatid exchange (SCE) and oxidative DNA damage. In this study, we examined the effect of vitamin E, which is known for its strong antioxidant activity, on the rate of SCE in cultured lymphocytes obtained from BD patients. In addition, the… Show more

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“…Chromosomal aberrations were visualized using Giemsa stain as previously described. 27 About 500 metaphases were examined per treatment by an individual who was unaware of treatment conditions. Chromosomal aberrations were scored using light microscope with 1000× magnification power.…”
Section: Methodsmentioning
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“…Chromosomal aberrations were visualized using Giemsa stain as previously described. 27 About 500 metaphases were examined per treatment by an individual who was unaware of treatment conditions. Chromosomal aberrations were scored using light microscope with 1000× magnification power.…”
Section: Methodsmentioning
“…The slides were analyzed blindly using medical microscope at 1000 magnification. About 200 well-spread metaphases were scored per each AFB1 concentration for the presence of chromosomal aberrations including (Cmetaphase, chromosomal gap, chromosomal fragments, chromatin bridge and stickiness) (Alzoubi et al, 2012;Khabour et al, 2015 ).…”
Section: Chromosome Aberration Assaymentioning