Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: A multi-biomarker approach

Kopjar, Nevenka; Garaj-Vrhovac, Verica; Kašuba, Vilena; Rozgaj, Ružica; Ramić, Snježana; Pavlica, Vesna; Želježić, Davor

doi:10.1016/j.ijheh.2008.10.001

Cited by 53 publications

(55 citation statements)

References 63 publications

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“…Additionally, most of these samples were from the administration units. Our results can be explained once again by the fact that there are more strict safety and hygiene rules in preparation units when compared with administration units as demonstrated by the high number of organizations that research on this field developing constantly new rules and safety measures (ISOPP 2007;NIOSH among others). This raises attention to another important aspect that should be considered for the risk assessment process: in this setting, exposure is characterized by being simultaneous to different antineoplastic drugs and the health effects of such mixtures are unpredictable (Fucic et al 1998;Cavallo et al 2005;Kopjar et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Viegas

Pádua

Veiga

et al. 2014

Environ Monit Assess

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Despite the classification as known or suspected human carcinogens, by the International Agency for Research on Cancer, the antineoplastic drugs are extensively used in cancer treatment due to their specificity and efficacy. As human carcinogens, these drugs represent a serious threat to the healthcare workers involved in their preparation and administration. This work aims to contribute to better characterize the occupational exposure of healthcare professionals to antineoplastic drugs, by assessing workplace surfaces contamination of pharmacy and administration units of two Portuguese hospitals. Surface contamination was assessed by the determination of cyclophosphamide, 5-fluorouracil, and paclitaxel. These three drugs were used as surrogate markers for surfaces contamination by cytotoxic drugs. Wipe samples were taken and analyzed by HPLC-DAD. From the total of 327 analyzed samples, in 121 (37 %) was possible to detect and quantify at least one drug. Additionally, 28 samples (8.6 %) indicate contamination by more than one antineoplastic drug, mainly in the administration unit, in both hospitals. Considering the findings in both hospitals, specific measures should be taken, particularly those related with the promotion of good practices and safety procedures and also routine monitoring of surfaces contamination in order to guarantee the appliance of safety measures.

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Section: Discussionmentioning

confidence: 99%

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Viegas

Pádua

Veiga

et al. 2014

Environ Monit Assess

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“…The International Agency for Research on Cancer (IARC) has classified many antineoplastic agents as class 1 human carcinogens (eg, cyclophosphamide, etoposide, busulfan, melfalan), class 2A probably carcinogenic to humans (eg, azacitidine, cisplatin, doxorubicine) or class 2B possibly carcinogenic to humans (bleomycin, dacarbazine, mitoxantrone, mitomycin) (20). Occupational exposure to antineoplastic agents has been shown to result in an increased frequency of total chromosomal aberrations (CATot) in PBL, as documented by a number of studies (2,(21)(22)(23)(24)(25)(26). Interestingly, nurses occupationally exposed to antineoplastic drugs showed an elevated level of not only chromatid-type aberrations (CTA) (induced by most chemical clastogens), but also chromosome-type aberrations (CSA), such as chromosome breaks and dicentric chromosomes, which is typical of radiation exposure (23).…”

Section: Musak Et Almentioning

confidence: 99%

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Musak¹,

Šmerhovský²,

Halašová³

et al. 2013

Scand J Work Environ Health

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We report significantly increased chromosomal damage among medical staff occupationally exposed to various genotoxic compounds in several medical professions. Potentially harmful exposures in hospital environment represent considerable health risk, since chromosomal aberrations have been found to be predictive of cancer risk, and an association between chromosomal damage and cancer risk has been shown. Affiliation:

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“…U Hrvatskoj (58,67,69,72,78,79) to je donedavno bila i jedina metoda koja se izvodila kao dodatna pretraga u okviru zdravstvenih pregleda medicinskog osoblja izloženog antineoplasticima. Iz grafičkog prikaza (slika 6) vidljivo je da je broj istraživanja, koja su primjenom SCE utvrdila pozitivne i negativne rezultate, sličan.…”

Section: Izmjene Sestrinskih Kromatida (Sce)unclassified

“…Do danas su objavljeni rezultati brojnih istraživanja (tablica 3), uključujući i nekoliko provedenih u Hrvatskoj (58,69,79,84). Iz odnosa broja istraživanja koja su prikazala pozitivne ili negativne rezultate dobivene primjenom CA (slika 6) vidljivo je da je važnost ove metode u otkrivanju genotoksičnih učinaka antineoplastika nešto manja negoli je važnost analize SCE.…”

Section: Oštećenja (Aberacije) Kromosomaunclassified

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Antineoplastic Drugs as a Potential Risk Factor in Occupational Settings: Mechanisms of Action at the Cell Level, Genotoxic Effects, and Their Detection Using Different Biomarkers

Kopjar

Želježić

Kašuba

et al. 2010

Archives of Industrial Hygiene and Toxicology

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Nevenka KOPJAR, Davor ŽELJEŽIĆ, Vilena KAŠUBA i Ružica ROZGAJ Institut za medicinska istraživanja i medicinu rada, Zagreb, HrvatskaPrimljeno u siječnju 2010. Prihvaćeno u veljači 2010.U članku je prikazana osnovna podjela antineoplastičnih lijekova prema mehanizmima djelovanja na razini stanice. Objašnjeni su mehanizmi genotoksičnosti najvažnijih vrsta lijekova koji se primjenjuju u okviru uobičajenih protokola za liječenje zloćudnih novotvorina. Navedena je važeća klasifi kacija antineoplastika prema kancerogenom potencijalu, podaci o mutagenom potencijalu te je prikazana njihova podjela u skladu s anatomsko-terapijsko-kemijskim sustavom klasifi kacije. Sustavno su prikazani najvažniji rezultati svjetskih i hrvatskih istraživanja na populacijama radnika izloženih antineoplasticima, provedenih u razdoblju 1980.-2009. s pomoću četiri najčešće primjenjivane metode: analize izmjena sestrinskih kromatida, analize kromosomskih aberacija, mikronukleus-testa i komet-testa. Objašnjena su osnovna načela navedenih metoda te raspravljene njihove prednosti i nedostaci. Biološki pokazatelji daju važne podatke o individualnoj osjetljivosti profesionalno izloženih ispitanika koji mogu poslužiti unaprjeđenju postojećih uvjeta rada i upravljanju rizicima pri izloženosti genotoksičnim agensima. Na osnovi prednosti i nedostataka citogenetičkih metoda zaključeno je da je mikronukleus-test, koji podjednako uspješno dokazuje klastogene i aneugene učinke, jedna od najboljih metoda dostupnih za otkrivanje štetnih djelovanja antineoplastičnih lijekova koji su u aktivnoj primjeni.

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Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: A multi-biomarker approach

Cited by 53 publications

References 63 publications

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Antineoplastic drugs contamination of workplace surfaces in two Portuguese hospitals

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Antineoplastic Drugs as a Potential Risk Factor in Occupational Settings: Mechanisms of Action at the Cell Level, Genotoxic Effects, and Their Detection Using Different Biomarkers

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