Assessment of estrogen receptor, progesterone receptor of infiltrating ductal carcinoma of breast for neoadjuvant chemotherapy

Abstract

Background: The aims and objectives of this study are to study the influence of Estrogen receptor ER, Progesterone receptor PR of patients having infiltrating ductal carcinoma of breast recieving Neoadjuvant chemotherapy, To study the influence of ER and PR receptors in patients receiving neoadjuvant chemotherapy & correlate complete pathological response. Methods  Type of study: Prospective clinical study. present study was carried out in the department of general surgery Vinayaka Missions medical college and hospital karaikal from July 2016 -December 2017. HPE (Histopathological examination) and ER PR status was done. Patients diagnosed with locally advanced breast cancer underwent simple randomization into 2 treatment groups. Group 1: AC (Adriamycin 60mg/m2, Cyclophosphamide 600mg/m2) once every 3 weeks for 4 cycles Group2: Docetaxel 75 mg/m2 for 4 cycles every 3 weekly(11). Clinical examination was performed after every two cycles and completing all the chemotherapy, study group patients were subjected to Modified radical mastectomy which was then followed by evaluation of pathological response. Conclusion:In this study 30 patients ER PR status was done. According to ER PR status Neoadjuvant chemotherapy regimen given. NCT response was assessed with clinical / imaging study. There was reduction in tumor size and change in lymph node status in both the groups with p value of .44. As our study size is small we cannot predict the actual outcome of the two study groups. We need larger sample size to predict the actual outcome. Results: The statistical analysis was performed by STATA 11.2. Descriptive statistics of frequency and percentage were performed all the study variables. Chi square test were used to measure the association between the CP response with ER status. P<0.05 considered as statistically significance.