2015
DOI: 10.2217/fon.14.292
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Abstract: The assessment of EMR by FDG PET/CT in patients with advanced gastrointestinal stromal tumor exposed to imatinib 800 mg was not predictive of PFS or overall survival.

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Cited by 16 publications
(8 citation statements)
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“…Treglia et al published another systematic review on the same topic and stated that therapy assessment based on FDG PET is a valuable method for early assessment not only to imatinib but also to other drugs, as well as for the prediction of therapy outcome [ 58 ]. However, this conclusion is not in accordance to our results, since no robust evidence has been yet provided, that early treatment response with FDG PET correlates to therapy outcome in terms of survival [ 39 – 44 , 51 55 ]. Therefore, more data are needed to support this statement.…”
Section: Imaging Methodscontrasting
confidence: 94%
See 1 more Smart Citation
“…Treglia et al published another systematic review on the same topic and stated that therapy assessment based on FDG PET is a valuable method for early assessment not only to imatinib but also to other drugs, as well as for the prediction of therapy outcome [ 58 ]. However, this conclusion is not in accordance to our results, since no robust evidence has been yet provided, that early treatment response with FDG PET correlates to therapy outcome in terms of survival [ 39 – 44 , 51 55 ]. Therefore, more data are needed to support this statement.…”
Section: Imaging Methodscontrasting
confidence: 94%
“…In contrast, Chacon et al studied 16 patients on day 7 and day 37 after starting treatment with 800 mg/day imatinib. They found that FDG uptake on day 7 is not predictive for PFS [ 39 ]. McAuliffe et al provided comparable results in 19 patients who underwent FDG PET prior to neoadjuvant therapy as well as after the end of the preoperative treatment within a randomized phase 2 trial [ 40 ].…”
Section: Imaging Methodsmentioning
confidence: 99%
“…• Literature search In 1973, non-duplicate articles were identified by using search strategies from which 63 potentially relevant papers were screened. Finally, 32 study were eligible, and 21 full-text articles included in meta-analysis and studied in detail 13,15,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] (Table 1, Fig. 1).…”
Section: Resultsmentioning
confidence: 99%
“…considering ring uptake and not semiquantitative values. Instead, a recent paper 21 founded no correlation between metabolic PET/CT response after treatment and PFS or OS. Nobody evaluated baseline 18 F‐FDG PET/CT parameters possible prognostic impact.…”
Section: Discussionmentioning
confidence: 98%
“…Aggressive GISTs can have a high risk of relapse/recurrence or distant metastasis, so they must be carefully observed and early detected to improve survival rates. F‐18‐fluorodeoxyglucose ( 18 F‐FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) is being increasingly used in GIST for staging purpose, 5‐11 restaging 12,13 and evaluation of treatment response, 14‐16 focus in some cases on patients treated with Imatinib 17‐22 . Instead, in literature are available controversial results concerning the predictive value of the 18 F‐FDG PET/CT 7,8,23,24 .…”
Section: Introductionmentioning
confidence: 99%