Assessment of diffusion‐weighted MR imaging in liver fibrosis

Annet, Laurence; Peeters, Frank; Abarca‐Quinones, Jorge; Leclercq, Isabelle; Moulin, Pierre; Beers, Bernard E. Van

doi:10.1002/jmri.20771

Cited by 133 publications

(127 citation statements)

References 41 publications

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“…Previous experience with physiological motion artifacts and poor image resolution have been addressed by the use of faster pulse sequences, cardiac and respiratory triggering, and modifying the acquisition to allow data collection during suspended respiration. 38,39 Reported times for breath-holding are usually between 10 and 20 seconds per measurement. Typical examination time for both standard and diffusion-weighted MRI is approximately 45 to 60 minutes.…”

Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

“…This suggests that reduced hepatic perfusion may explain the decrease seen for in vivo ADC values with increasing degrees of fibrosis, which has been theorized when using lower b values. 38 Several aspects of diffusion-weighted MRI liver imaging require attention before extending its application in human subjects. Studies have used small numbers of patients and various hardware and sequencing profiles, rendering comparisons between experiences difficult.…”

Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

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Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

et al. 2007

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Chronic liver disease and cirrhosis remains a major public health problem worldwide. While the majority of complications from chronic liver disease result from progressive hepatic fibrosis, the available diagnostic tests used in clinical practice are not sensitive or specific enough to detect occult liver injury at early or intermediate stages. While liver biopsy can stage the extent of fibrosis at diagnosis, its utility as a tool for longitudinal monitoring will be limited at the population level. To date, a number of methods including serum marker panels and ultrasound-based transient elastrography have been proposed for the non-invasive identification of hepatic fibrosis. Novel techniques including magnetic resonance (MR) spectroscopy, diffusion weighted MR, and MR elastography have also emerged for detecting fibrosis. In contrast to other non-invasive methods, MR imaging holds the promise of providing functional and biological information about hepatic pathophysiology as it relates to the natural history and future treatment of hepatic fibrosis. (HEPATOLOGY 2008;47:332-342.)

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Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

Section: Novel Mr Applications For In Vivo Detection Of Hepatic Fibrosismentioning

confidence: 99%

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

et al. 2007

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“…However, this difference was not found in dead animals and fixed tissues (35). The ADC difference among dead and living rats was related to perfusion effects.…”

Section: Discussionmentioning

confidence: 70%

“…The ADC difference among dead and living rats was related to perfusion effects. Decreased perfusion due to liver fibrosis has been seen in a number of studies (32,35,41,42). In a study conducted with cirrhotic live dogs, the ADC was lower in the cirrhotic lobes than in normal lobes; however, lobal differences in the ADC values disappeared after portal vein clamping (43).…”

Section: Discussionmentioning

confidence: 99%

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Utility of diffusion-weighted magnetic resonance imaging for liver fibrosis in chronic active hepatitis

Soylu¹,

Kılıçkesmez²,

Poturoğlu³

et al. 2009

Diagn Interv Radiol

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Chronic hepatitis: Role of diffusion‐weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation

Taouli

Chouli

Martin

et al. 2008

Magnetic Resonance Imaging

192

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Purpose: To determine the diagnostic performance of liver apparent diffusion coefficient (ADC) measured with conventional diffusion-weighted imaging (CDI) and diffusion tensor imaging (DTI) for the diagnosis of liver fibrosis and inflammation. Materials and Methods:Breathhold single-shot echo-planar imaging CDI and DTI with b-values of 0 and 500 second/mm 2 was performed in 31 patients with chronic liver disease and 13 normal volunteers. Liver biopsy was performed in all patients with liver disease with a median delay of two days from MRI. Fibrosis and inflammation were scored on a 5-point scale (0 -4). Liver ADCs obtained with CDI and DTI were compared between patients stratified by fibrosis stage and inflammation grade. Receiver operating characteristic (ROC) curve analyses were conducted to evaluate the utility of the ADC measures for prediction of fibrosis and inflammation. Results:Patients with liver fibrosis and inflammation had significantly lower liver ADC than subjects without fibrosis or inflammation with CDI and DTI. For prediction of fibrosis stage Ն 1 and stage Ն 2, area under the ROC curve (AUC) of 0.848 and 0.783, sensitivity of 88.5% to 73.7%, and specificity of 73.3% to 72.7% were obtained, for ADC Յ1.40 ϫ 10 -3 mm 2 /second and Յ1.30 ϫ 10 -3 mm 2 /second (using CDI), respectively. For prediction of inflammation grade Ն 1, AUC of 0.825, sensitivity of 75.0%, and specificity of 78.6% were obtained using ADC Յ 1.30 ϫ 10 -3 mm 2 /second (using CDI). CDI performed better than DTI for diagnosis of fibrosis and inflammation. Conclusion:Liver ADC can be used to predict liver fibrosis and inflammation with acceptable sensitivity and specificity.

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Assessment of diffusion‐weighted MR imaging in liver fibrosis

Cited by 133 publications

References 41 publications

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

Utility of diffusion-weighted magnetic resonance imaging for liver fibrosis in chronic active hepatitis

Chronic hepatitis: Role of diffusion‐weighted imaging and diffusion tensor imaging for the diagnosis of liver fibrosis and inflammation

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