Assessment of DDT, DDE, and 1-hydroxypyrene levels in blood and urine samples in children from Chiapas Mexico

Martínez-Salinas, Rebeca I.; Pérez-Maldonado, Iván N.; Batres-Esquivel, Lilia E.; Flores-Ramírez, Rogelio; Dı́az-Barriga, Fernando

doi:10.1007/s11356-012-0758-7

Cited by 31 publications

(10 citation statements)

References 53 publications

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“…On the other hand, in agreement to environmental and human exposure values to POPs [36,[42][43][44], the detection and quantification limits found in this work are acceptable for biomonitoring. The simplicity and sensitivity of this technique allows it to be applied in biomonitoring programs in order to assess the presence of POPs mixtures in children and the general population, particularly at polluted sites, many of which exist in developing countries due to an extensive use of these compounds.…”

Section: Discussionsupporting

confidence: 83%

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Rapid analysis of persistent organic pollutants by solid phase microextraction in serum samples

Flores-Ramírez

Ortiz-Pérez

Batres-Esquivel

et al. 2014

Talanta

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Section: Discussionsupporting

confidence: 83%

“…Indoor use of wood [27]. Exposure to POPs varies significantly in all sites (Table 4) [36][37][38]. Although all studies were performed with children born in these sites, there are different patterns of exposure; a fact that is explained by their different types of culture and environment [39].…”

Section: Biomonitoring Of Ocps and Pcbs In Mexican Childrenmentioning

confidence: 99%

Rapid analysis of persistent organic pollutants by solid phase microextraction in serum samples

Flores-Ramírez

Ortiz-Pérez

Batres-Esquivel

et al. 2014

Talanta

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“…However, pyrene is almost always present in the mixtures regardless of the type of burned material (Jongeneelen, , ). Therefore, a pyrene metabolite (1‐hydroxypyrene) has been widely used to evaluate exposure to PAHs in the human population (Martínez‐salinas et al, ; Pruneda‐Álvarez et al, ; Trejo‐Acevedo et al, ; Domínguez‐Cortinas et al, ; Pérez‐Maldonado et al, ; Ruiz‐Vera et al, ; Pruneda‐Álvarez et al, ; Pérez‐Maldonado et al, ). Exposure to PAHs has been associated with several adverse human health effects (Mumtaz and George, ; Kim et al, ), like some cancer types (lung, skin, bladder and gastrointestinal) (Bach et al, ; Olsson et al, ; Diggs et al, ) as well as gastrointestinal, pulmonary, dermatologic, and renal afflictions (Mumtaz and George, ).…”

Section: Introductionmentioning

confidence: 99%

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been considered a risk determinant for the development of cardiovascular diseases (CVD). Therefore, the aim of this study was to assess expression levels of vascular‐related miRNAs, miR‐126, miR‐155, and miR‐145, in plasma from women (aged 19–81 years) exposed (n = 100) and non‐exposed (n = 20) to PAHs via biomass combustion smoke.1‐hydroxypyrene (1‐OHP) was determined in urine as a biomarker of exposure to PAHs using high‐resolution liquid chromatography. Plasma expression levels of proposed miRNAs were determined by quantitative real‐time PCR. Additionally, traditional risk factors (age, blood pressure, serum lipid profile, blood glucose, and among others) associated with CVD were evaluated. Urinary 1‐OHP concentrations and plasma expression levels of miR‐126 and miR‐155 were significantly higher (P < 0.05) in women using wood as a fuel source in their homes (indoor) compared to women from the reference group (non‐exposed to biomass smoke). Besides, multivariate linear regression analyses revealed that miR‐126[β = 0.61; 95% confidence interval (0.32–0.90)] and miR‐155 [β = 0.45; 95% confidence interval (0.13–0.84)] expression levels were significantly associated with urinary 1‐OHP concentrations after being adjusted by traditional risk factors (P < 0.05). In contrast, no significant relationship was found between miR‐145 and urinary 1‐OHP levels. Furthermore, miRNAs assessed in this investigation are associated with CVD events. Consequently, actions to reduce exposure to PAHs in the evaluated population are warranted. Environ. Mol. Mutagen. 60:546–558, 2019. © 2019 Wiley Periodicals, Inc.

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“…Moreover, it was noted that populations are exposed to proinflammatory compounds (as DDE and PCB153) and compounds such as PAHs, PCBs, and TCCD (AhR agonists) simultaneously (Costilla-Salazar et al, 2011;Martínez-Salinas et al, 2011;PerezMaldonado et al, 2013;Trejo-Acevedo et al, 2012). Thus, it is important to assess potential toxicological interactions between components of a chemical mixture in exposed populations.…”

Section: Discussionmentioning

confidence: 99%

DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells

Gaspar-Ramírez

Pérez‐Vázquez

Salgado‐Bustamante³

et al. 2014

Journal of Immunotoxicology

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Recent studies have demonstrated that compounds inducing pro-inflammatory cytokines enhance AhR expression. The aim of this study was 2-fold: (1) to determine if two pro-inflammatory compounds, dichlorodiphenyldichloroethylene (DDE) and 2,2 0 ,4,4 0 ,5,5 0 -hexa-chlorobiphenyl (PCB 153), independently affect AhR gene expression in peripheral blood mononuclear cells (PBMC); and (2) if affected, to determine whether the mechanism involved was due to AhR activation or to a pro-inflammatory effect of the chemicals. PBMC isolated from healthy individuals were incubated in the presence of DDE (10 mg/ml) and PCB 153 (20 ng/ml) over time and AhR and CYP1A1 expression was assessed with a real-time PCR technique. The results indicated there was over-expression of the AhR mRNA in PBMC when the cells were treated with DDE and PCB 153. No changes in expression levels of CYP1A1 mRNA were found. Importantly, when the cells were exposed to DDE and PCB 153 in the presence of an antagonist of tumor necrosis factor (TNF)-, the over-expression of AhR was abolished; as expected, the expression of CYP1A1 was unaffected. In conclusion, these studies demonstrated for the first time an increment of AhR expression ''in vitro'' in PBMC treated with two pro-inflammatory environmental pollutants, DDE and PCB153. Moreover, the over-expression of AhR was dependent of TNF induced by DDE and PCB 153 and was independent of AhR activation.

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Assessment of DDT, DDE, and 1-hydroxypyrene levels in blood and urine samples in children from Chiapas Mexico

Abstract: This study demonstrates that children in these communities were exposed to DDT and its metabolites, and to other contaminants generated by the combustion of firewood. Therefore, the complex mixture studied in this study (PAHs and DDT/DDE) requires further research.

Cited by 31 publications

References 53 publications

Rapid analysis of persistent organic pollutants by solid phase microextraction in serum samples

Rapid analysis of persistent organic pollutants by solid phase microextraction in serum samples

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

DDE and PCB 153 independently induce aryl hydrocarbon receptor (AhR) expression in peripheral blood mononuclear cells

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