Assessment of Coronary Artery Plaque Characteristics and Distribution in Patients of South Asian Descent Using Coronary Computed Tomographic Angiography

Ramjattan, Neiman; Bulsara, Kishen; Ceron, Carlos; D'Angelo, Kyla; Verma, Gagan; Hai, Ofek; Zeltser, Roman; Makaryus, Amgad N.

doi:10.1016/s0735-1097(19)32239-9

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals with CVR and symptomatic for CAD are screened using noninvasive procedures such as echocardiogram, coronary computed tomography angiography (CCTA), and/or coronary magnetic resonance imaging [19][20][21]. The CCTA is an example of a non-invasive imaging procedure that can be used to screen, diagnose, and monitor the progression of CAD [1,22,23]. The overall anatomy of the heart is analysed during the noncontrast phase whereby the composition of calcium deposition in the atherosclerosis plaque is quanti ed by the semi-auto-calculation system called the coronary artery calcium score.…”

Section: Introductionmentioning

confidence: 99%

The Role of Ramus Intermedius in Atherosclerosis Plaque Deposition at the Left Bifurcation Region: A Retrospective Study using Coronary Computed Tomography Angiography

ROSANI

Zamin

Zulkafli

et al. 2022

Preprint

View full text Add to dashboard Cite

Ramus intermedius (RI) is a coronary artery anatomical variant arising from the left main bifurcation angle coursing between the left anterior descending and left circumflex arteries. RI is commonly reported in coronary artery investigations, but its role in coronary artery disease (CAD) is unknown. The objective of this study is to evaluate the contributory effects of the RI in the development of CAD at the left bifurcation region (LBR) using coronary computed tomography angiography (CCTA). A retrospective cross-sectional single-centre study was conducted on patients who underwent CCTA from January 2017 until December 2018. A total of 374 patients were included based on inclusion and exclusion criteria. The left main coronary artery (LMCA), proximal left anterior descending (pLAD), and proximal left circumflex (pLCx) arteries were analysed against known cardiovascular risks (CVR) (i.e., Absence or Presence). The RI was identified in 32% of patients (n = 121). RI singularly increases the risk for plaque deposition at the LMCA and pLAD but not in the pLCx. RI increased the risk for LMCA stenosis by eight-fold (Adjusted OR, aOR: 8.5, 95% CI: 1.7, 43.0, p = 0.010). At the pLAD, a RI increased the risk for plaque deposition at the lateral wall by three-fold (aOR: 3.5, 95% CI: 1.1, 11.3, p = 0.036) and four-fold for plaque formation on both lateral and medial walls (aOR: 4.3, 95% CI: 2.7, 17.2, p = 0.038). These findings suggested for the first time that RI pose an elevated risk for atherosclerosis in coronary arteries.

show abstract

Section: Introductionmentioning

confidence: 99%

The Role of Ramus Intermedius in Atherosclerosis Plaque Deposition at the Left Bifurcation Region: A Retrospective Study using Coronary Computed Tomography Angiography

ROSANI

Zamin

Zulkafli

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In this context, the technological development of 3rd generation Dual Source multidetector CT scanners has fostered the possibilities to identify and characterize CAD also in complex cardiovascular anatomy and non-compliant patients, in fact promoting CCTA as a screening method towards more invasive procedures (e.g., coronary angiography) [18]. The 'napkin ring' sign, positive parietal remodeling, low density of the non-calcific component, and low or no plaque calcification are among the criteria of plaque vulnerability that are now feasible and thought to be at least somewhat trustworthy [19]. Although several of these characteristics are more challenging to replicate and resolve, current developments in photon-counting CT technology promise to overcome any resolution and plaque tissue characterization constraints [20].…”

Section: Discussionmentioning

confidence: 99%

Stratification of Patients with Coronary Artery Disease by Circulating Cytokines Profile: A Pilot Study

Iside,

Affinito,

Punzo

et al. 2023

JCM

View full text Add to dashboard Cite

Coronary artery disease (CAD) is a long-term inflammatory process, with atherosclerosis as its underlying pathophysiological mechanism. Endothelial dysfunction is the first step towards atherosclerosis, where damaged endothelial cells release large amounts of pro-inflammatory cytokines and mediators, thus promoting vascular inflammation and disease progression. However, the correlation between serum cytokines and CAD severity remains to be defined. Serum samples from patients performing cardiac computed tomography for suspected CAD (n = 75) were analyzed with a multiplex bead-based immunoassay panel for simultaneous assessment of the concentration of 11 cytokines using flow cytometric technology. The analysis showed statistically significant increases in sRAGE, CCL2_MCP1, FLT1, and IL6 levels in CAD patients compared with healthy subjects and a gradual increase trend towards a more severe form of the disease for most cytokines (e.g., sCD40L, FLT1, sRAGE, CCL2-MCP1, TNFα). Lastly, we explored the performance of cytokines in predicting the diagnosis of CAD and found that an increase in IL6 levels will increase the odds of being non-obstructive CAD-positive. In contrast, an increase in CCL2-MCP1 or FLT1 levels will increase the probability of being obstructive CAD-positive. These results suggest that the combination of serum cytokines may contribute to the not-invasive stratification risk for patients with suspected CAD.

show abstract

“…1-2 hours before the procedure, an oral beta-blocker or oral Ivabradine is administered to the patient depending on their resting heart rate. Metoprolol tartrate 50 mg to 100 mg or Ivabradine 5mg to 10mg was the oral pre-medications used to reduce heart rate during CTA since a heart rate of 60 beats per minute or less is ideal for CTA procedure (9). Then the CTA procedure was performed by injecting the dye and obtaining CT films before, during and after the perfusion of dye.…”

Section: Methodsmentioning

confidence: 99%

Coronary Computed Tomography Angiography (CTA) and Coronary Angiography (CAG) in the investigation of Coronary Artery Disease (CAD): A Retrospective study

Aggarwal¹,

Bansal²

2023

IJFMR

View full text Add to dashboard Cite

Coronary angiography (CAG) is the conventional procedure, considered the gold standard for the examination of coronary arteries. Being a standardised procedure, CAG is comparatively safer but an invasive procedure. Therefore, it carries some amount of risk compared to Coronary computed tomography angiography (CTA). CTA is comparatively a new technique but is non-invasive and is reported to be as or more accurate and efficient as functional stress test in diagnosis of CAD and comparable to CAG. In this retrospective study, we have analysed data of 76 patients who underwent CTA. Further 18 patients from these 76, especially with higher percentage of stenosis underwent CAG. Thus CTA could be used as a screening (non invasive) method for exam

show abstract

Assessment of Coronary Artery Plaque Characteristics and Distribution in Patients of South Asian Descent Using Coronary Computed Tomographic Angiography

Cited by 6 publications

References 0 publications

The Role of Ramus Intermedius in Atherosclerosis Plaque Deposition at the Left Bifurcation Region: A Retrospective Study using Coronary Computed Tomography Angiography

The Role of Ramus Intermedius in Atherosclerosis Plaque Deposition at the Left Bifurcation Region: A Retrospective Study using Coronary Computed Tomography Angiography

Stratification of Patients with Coronary Artery Disease by Circulating Cytokines Profile: A Pilot Study

Coronary Computed Tomography Angiography (CTA) and Coronary Angiography (CAG) in the investigation of Coronary Artery Disease (CAD): A Retrospective study

Contact Info

Product

Resources

About