Assessment of changes in the lesions sizes and the incidence of complete epithelialization during the treatment of diabetic foot syndrome over a period of 4 weeks (multicenter study)

Stupin, Victor; Silina, Ekaterina; Goryunov, S. V.; Gorskiy, V. A.; Кривихин, В. Т.; Bogomolov, M S; Баранцевич, Е. Р.; Корейба, Константин Александрович

doi:10.17116/hirurgia2017355-60

Cited by 11 publications

(8 citation statements)

References 7 publications

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“…The positive effect of collagen that we have established experimentally confirms the clinical effectiveness of its use even in the treatment of chronic wounds. [15][16][17] This allows us to conclude about the unity of the mechanisms of collagen influence on acute and chronic wound regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…All selected injectables were of biological origin and derived from mammals; their effectiveness in wound treatment has been previously proven in clinical and experimental studies. These include collagen (Collost ® ; which contains native unreconstructed collagen obtained from the skin of cattle), [15][16][17][18][19] deproteinized calf blood hemoderivative (DCBH; Actovegin ® ), [20][21][22] and mesenchymal stem cells (SCs). [23][24][25][26][27][28] An obvious advantage of the injectable drugs is the ability to accurately administer a certain volume and dose of the drug to the same location in all animals, providing identical wound treatment conditions.…”

Section: Introductionmentioning

confidence: 99%

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<p>Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation</p>

Silina

Мантурова

Litvitskiy

et al. 2020

DDDT

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Purpose To investigate the comparative effectiveness of certain biological injectable stimulants for the healing of skin wounds and criteria for its assessment. Materials and Methods A comparative study of the effectiveness of mesenchymal stem cells (SC group), collagen (Collagen group), and deproteinized calf blood hemoderivative (DCBH group) was carried out using an acute wound model. Control wounds were injected with isotonic sodium chloride solution (Control group). A total of four groups (28 wounds per group) were included in the study. Aged male Wistar rats were used as experimental animals. A dynamic assessment of the wound areas and edges, microvasculature assessment via laser Doppler flowmetry, histological and morphometric analyses to determine the quantitative and qualitative fibroblasts composition, as well as the degree of newly synthesized collagen maturity, was conducted on days 0, 3, 7, and 14. Results The administration of SCs provided a rapid but short-lasting effect, whereas the administration of collagen resulted in a delayed but long-lasting wound-healing effect. DCBH resulted in little to no effect. An increase in the perfusion volume of the wound edges accelerated the regeneration process, while the level of microcirculation did not affect the number and activity of fibroblasts. The wound healing acceleration, as well as the new collagen and stratified epithelium formation and maturation, was associated with the presence of a sufficient pool of mature and active fibroblasts in the wound, and not with the number of fibroblasts. Conclusion The present results clarify the action mechanisms of the studied drugs. In addition, the application purposes and different effects of each drug on the different wound healing phases were demonstrated. An assumption on the multi-component treatment advisability under the wound condition objective assessment possibility was made. Findings from this study may assist clinicians in making an informed transition to personalized wound management and achieve better clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation</p>

Silina

Мантурова

Litvitskiy

et al. 2020

DDDT

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“…It is important to emphasize that the use of native collagen products does not produce side effects (58,59,63,64,68), which attests to high safety of this treatment.…”

Section: Use Of Native Collagen In the Treatment Of Diabetic Foot Synmentioning

confidence: 97%

“…Use of Collost led to a 1.8-fold reduction in time of wound preparation for autodermoplastic closure (32.0±4.6 days versus 56.8±8.7 days in the comparator group) (62). Preliminary results of a multicenter, randomized prospective clinical trial encompassing 71 patients with diabetic foot syndrome Wagner II -III showed that native collagen (Collost) effectively decreased the length, width, area and volume of diabetic ulcers so that epithelialization could occur faster (63,64). After 4 weeks of treatment, complete epithelialization was observed in 22.2% of patients from the main group (Collost) and in 8.6% of patients from the comparator group (standard therapy).…”

Section: Use Of Native Collagen In the Treatment Of Diabetic Foot Synmentioning

confidence: 99%

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.

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“…Как гелевая форма биоматериал Коллост активно используется в общехирургической практике для регенерации мягких тканей в лечении хронических ран, трофических язв, синдрома диабетической стопы. Проведенные исследования и аналитические обзоры показывают высокую эффективность коллагенового биоматериала в лечении хронических раневых дефектов различной этиологии [5][6][7][8][9].…”

Section: Clinical Estimation Of the Efficacy Mesenchymal Stem Cells Aunclassified

Clinical estimation of the efficacy mesenchymal stem cells and bioplastic material Collost for treating gingival recession in the experiment in vivo

Рубникович¹,

Denisova²,

Andreeva³

et al. 2018

Ross. stomatol.

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Assessment of changes in the lesions sizes and the incidence of complete epithelialization during the treatment of diabetic foot syndrome over a period of 4 weeks (multicenter study)

Cited by 11 publications

References 7 publications

<p>Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation</p>

<p>Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation</p>

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Clinical estimation of the efficacy mesenchymal stem cells and bioplastic material Collost for treating gingival recession in the experiment in vivo

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