Assessment of cardiac troponin I and C-reactive protein concentrations associated with anesthetic protocols using sevoflurane or a combination of fentanyl, midazolam, and sevoflurane in dogs

Effect of surgeon experience on postoperative plasma cortisol and C‐reactive protein concentrations after ovariohysterectomy in the dog: a randomised trial

“…[26][27][28] At the 6-h endpoint sampling in the present trial, CRP concentrations were still rising and the literature describes concentrations peaking at between 24 and 48 h post-surgery. The authors consider these factors to be less likely to have a strong influence on CRP concentrations because CRP is released in response to peripheral cytokines in circulation, which well-managed anaesthesia should invoke at much lower concentrations than surgical tissue trauma.…”

Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty

“…25 Results did not show any significant effect of the anesthetic protocol used here on the cardiac biomarkers evaluated in this study.…”

“…In a study by our group, healthy dogs presenting for elective ovariohysterectomy or castration and anesthetized using the same protocol used in this study did not show significant increases in serum cTnI concentration following anesthesia. 25 Serum CRP concentrations significantly increased post-anesthetic induction which was attributed to surgical trauma.…”

The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis

“…It is possible that drugs used in inducing and maintaining general anaesthesia can cause alterations in the blood (and therefore perhaps also in synovial fluid) concentration of CRP in both humans [43-45] and dogs [46] although in all these studies the patients also underwent surgery and this is much more likely to be the stimulus for elevation of CRP levels. In our study, both pre- and post-treatment blood samples were collected from conscious dogs but the 2 synovial fluid samples were collected whilst the dogs were anaesthetized, within minutes of the dog losing consciousness and before any surgical stimulus.…”

“…In our study, both pre- and post-treatment blood samples were collected from conscious dogs but the 2 synovial fluid samples were collected whilst the dogs were anaesthetized, within minutes of the dog losing consciousness and before any surgical stimulus. The fact that both synovial fluid samples were collected under general anaesthesia means that comparison of CRP concentrations in the pre-and post-treatment samples should not be compromised, even if the anaesthetic agents do have an effect since the same anaesthetic protocol was always used and any effect of the anaesthetic is likely to take several hours [46]. …”