Assessment of 193 Candidate Genes for Retinopathy in African Americans With Type 1 Diabetes

Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy

“…However, a recent report by Roy et al indicated that SLC2A1 (GLUT1) polymorphism rs841846 was associated with progression of DR in African-Americans with type 1 diabetes (Roy et al, 2009). In contrast to the finding by Roy et al, our study showed that rs841846 polymorphism was not associated with DR but 26177G minor allele was significantly present in DNR patients.…”

“…This contradictory finding could be explained by the differences in genetic background and population history between African-Americans and Malaysians. Besides, the different pathological features between type 1 diabetes (Roy et al, 2009) and type 2 diabetes in this study could also contribute to this contrast finding. This study provides further evidence that GLUT1 polymorphism might contribute to susceptibility to type 2 diabetes (Baroni et al, 1992;Pontiroli et al, 1996;Tao et al, 1995).…”

Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy

“…However, a recent report by Roy et al indicated that SLC2A1 (GLUT1) polymorphism rs841846 was associated with progression of DR in African-Americans with type 1 diabetes (Roy et al, 2009). In contrast to the finding by Roy et al, our study showed that rs841846 polymorphism was not associated with DR but 26177G minor allele was significantly present in DNR patients.…”

“…This contradictory finding could be explained by the differences in genetic background and population history between African-Americans and Malaysians. Besides, the different pathological features between type 1 diabetes (Roy et al, 2009) and type 2 diabetes in this study could also contribute to this contrast finding. This study provides further evidence that GLUT1 polymorphism might contribute to susceptibility to type 2 diabetes (Baroni et al, 1992;Pontiroli et al, 1996;Tao et al, 1995).…”

Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy

“…PPAR alpha and PPAR gamma are involved in the regulation of lipid and glucose metabolism, and have an important impact on the development of diabetic microvascular complications, which include nephropathy and retinopathy. Furthermore, a recent study revealed that RXR alpha (RXRA) poses antioxidants properties and is associated with the development of DR (Chai et al, 2008;Roy et al, 2009). Besides, we found that the RXRG gene has a role in the pathogenesis of diabetic nephropathy, as noted in our previous article (Hsieh et al, 2006).…”

The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy

“…We investigated the association of previously reported signals for retinopathy with SDR in our meta-analysis. The list for replication comprised three different sources: Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1). Top reported signals ( P < 10 −5 , 22 SNPs in 11 loci) in a previous GWAS of retinopathy in individuals without diabetes (Jensen et al 2013 ).…”

“…Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1).…”

Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy

“…However, a recent report by Roy et al indicated that SLC2A1 (GLUT1) polymorphism rs841846 was associated with progression of DR in African-Americans with type 1 diabetes (Roy et al, 2009). In contrast to the finding by Roy et al, our study showed that rs841846 polymorphism was not associated with DR but 26177G minor allele was significantly present in DNR patients.…”

“…This contradictory finding could be explained by the differences in genetic background and population history between African-Americans and Malaysians. Besides, the different pathological features between type 1 diabetes (Roy et al, 2009) and type 2 diabetes in this study could also contribute to this contrast finding. This study provides further evidence that GLUT1 polymorphism might contribute to susceptibility to type 2 diabetes (Baroni et al, 1992;Pontiroli et al, 1996;Tao et al, 1995).…”

Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy

“…PPAR alpha and PPAR gamma are involved in the regulation of lipid and glucose metabolism, and have an important impact on the development of diabetic microvascular complications, which include nephropathy and retinopathy. Furthermore, a recent study revealed that RXR alpha (RXRA) poses antioxidants properties and is associated with the development of DR (Chai et al, 2008;Roy et al, 2009). Besides, we found that the RXRG gene has a role in the pathogenesis of diabetic nephropathy, as noted in our previous article (Hsieh et al, 2006).…”

The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy

“…We investigated the association of previously reported signals for retinopathy with SDR in our meta-analysis. The list for replication comprised three different sources: Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1). Top reported signals ( P < 10 −5 , 22 SNPs in 11 loci) in a previous GWAS of retinopathy in individuals without diabetes (Jensen et al 2013 ).…”

“…Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1).…”

Investigation of SLC2A1 26177A/G gene polymorphism via high resolution melting curve analysis in Malaysian patients with diabetic retinopathy

“…However, a recent report by Roy et al indicated that SLC2A1 (GLUT1) polymorphism rs841846 was associated with progression of DR in African-Americans with type 1 diabetes (Roy et al, 2009). In contrast to the finding by Roy et al, our study showed that rs841846 polymorphism was not associated with DR but 26177G minor allele was significantly present in DNR patients.…”

“…This contradictory finding could be explained by the differences in genetic background and population history between African-Americans and Malaysians. Besides, the different pathological features between type 1 diabetes (Roy et al, 2009) and type 2 diabetes in this study could also contribute to this contrast finding. This study provides further evidence that GLUT1 polymorphism might contribute to susceptibility to type 2 diabetes (Baroni et al, 1992;Pontiroli et al, 1996;Tao et al, 1995).…”

Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy

“…PPAR alpha and PPAR gamma are involved in the regulation of lipid and glucose metabolism, and have an important impact on the development of diabetic microvascular complications, which include nephropathy and retinopathy. Furthermore, a recent study revealed that RXR alpha (RXRA) poses antioxidants properties and is associated with the development of DR (Chai et al, 2008;Roy et al, 2009). Besides, we found that the RXRG gene has a role in the pathogenesis of diabetic nephropathy, as noted in our previous article (Hsieh et al, 2006).…”

The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy

“…We investigated the association of previously reported signals for retinopathy with SDR in our meta-analysis. The list for replication comprised three different sources: Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1). Top reported signals ( P < 10 −5 , 22 SNPs in 11 loci) in a previous GWAS of retinopathy in individuals without diabetes (Jensen et al 2013 ).…”

“…Top reported signals ( P < 10 −5 , 54 SNPs in 11 loci) in previous GWAS studies of DR including two large candidate gene association studies with genome-wide coverage (Roy et al 2009 ; Sobrin et al 2011 ) (Table S1).…”