DOI: 10.5772/intechopen.90131
View full text
Mark D. Scott, Kerryn Matthews, Hongshen Ma

Abstract: Among the most crucial rheological characteristics of blood cells within the vasculature is their ability to undergo the shape change (i.e., deform). The significance of cellular deformability is readily apparent based solely on the disparate mean size of human erythrocytes (~8 μm) and leukocytes (10-25 μm) compared to the minimum luminal size of capillaries (4-5 μm) and splenic interendothelial clefts (0.5-1.0 μm) they must transit. Changes in the deformability of either cell will result in their premature me…

expand abstract