Introduction: Musculoskeletal disorders are one of the most common and costly occupational injuries. Nursing profession, considering the nature of the work, is one of the occupations in hospital in which work-related musculoskeletal disorders are highly prevalent. This review study was conducted to determine the prevalence of musculoskeletal disorders among Iranian nurses. Materials and methods: The present study was conducted on the basis of the PRISMA checklist for systematic review and meta-analysis. To access eligible articles, domestic and foreign databases such as Web of Science, Scopus, Science Direct, PUBMED, Magiran, SID, Medlib Irandoc, and the Google scholar search engine and keywords of musculoskeletal disorders, ergonomics, nurses, and Iran were used. In this review, two researchers reviewed the relevant articles published from 2000 to 2017. At first, 1349 papers were entered but finally, 33 eligible articles were analyzed. Data analysis was carried out using STATA software (ver. 11.5). Findings: The results of the review of 33 eligible articles showed that the prevalence of musculoskeletal disorders and low back pain in nurses were 0.84 (95% CI: 0.83-0.95) and 0.60 (95% CI: 0.60-0.61) respectively. Conclusion: The results of the previous studies revealed that the prevalence of musculoskeletal disorders, especially low back pain in nurses, is high. Therefore, planning and intervention should be performed to prevent and reduce musculoskeletal disorders in nurses.