Abstract:Background The interferon-gamma (IFN-γ) signaling pathway is activated in Systemic lupus erythematosus (SLE). This study aims to assess the causal association between IFN-γ, IFN-γR1, and IFN-γR2 and SLE within a bidirectional Mendelian-randomization design.Methods Genetic instruments of exposure to IFN-γ, IFN-γR1, and IFN-γR2 were derived from the large genome-wide association study (GWAS), including 3,301 sample size. Instrumental variables for SLE were selected from another independent GWAS analysis comprisi… Show more
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