Assessing the benefits of natriuretic peptides-guided therapy in chronic heart failure

Abstract

Heart failure (HF) is a major public heart burden among the ageing population. (Cardiol J 2015; 22, 1: 5-11)

Soluble ST2 protein and hospitalizations due to worsening chronic heart failure during a one-year follow-up in a population with reduced ejection fraction

“…24,25 In CHF, measurements of natriuretic peptide (NP) levels provide independent information regarding the risk for hospitalization for HF, and NP-guided therapy can reduce all-cause mortality and HF-related hospitalizations. 24,26 The present study did not find a correlation between hospitalization and NTproBNP. In contrast to other studies, in which patients entering the survey were hospitalized due to HF decompensation, in the present study they were in clinical stable CHF.…”

Predictors of Natriuretic Peptide Non-Response in Patients Hospitalized With Acute Heart Failure

“…11,12 The Use of Peptides in Tailoring Heart Failure Project study was the first trial to emphasize the concept of "responder" and "nonresponder" patients. 4 Responders were defined as patients whose NP levels decrease by >30% during a definite time period in response to the HF strategy in use.…”

Can ivabradine reduce NT-proBNP and improve outcomes in systolic heart failure?

“…In the study by Ordu et al [10] NT-proBNP significantly decreased from 1.353 ± 1.454 to 718 ± ± 835 pg/L. However, standard deviation is greater than the mean value and the detected changes might be within the well-known spontaneous fluctuations observed in patients with severe congestive HF [14]. Perhaps ivabradine decreased NT-proBNP, at least in some patients.…”

“…Perhaps ivabradine decreased NT-proBNP, at least in some patients. Nonetheless, the end-values are still much higher than the levels regarded as necessary to consider if medical therapy is adequate [14].…”

“…NT-proBNP is a well-known cardiac marker which has been extensively used to assess the benefits of BNP-guided therapy in chronic HF [14]. In the study by Ordu et al [10] NT-proBNP significantly decreased from 1.353 ± 1.454 to 718 ± ± 835 pg/L.…”