Assessing quality of life in the treatment of patients with age-related macular degeneration: clinical research findings and recommendations for clinical practice

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

“…In our series, we found that the baseline NEI-VFQ-25 composite score in our population was 82.14, which is higher than the results of previous studies (68.0–79.4) including the MARINA and ANCHOR trials [17,23,28,29,30,31]. Our results complement previous studies in other populations such as that of Oshima et al [17].…”

“…Our data show that treatment of nAMD significantly improves QoL regardless of clinical response and that this improvement is clinically significant with mean gains in NEI-VFQ 25 total scores exceeding the 4-point threshold established for nAMD [ 12 , 29 , 32 , 33 ]. Most of this improvement occurs during the loading phase, with slower gains during the extension phase.…”

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

“…In our series, we found that the baseline NEI-VFQ-25 composite score in our population was 82.14, which is higher than the results of previous studies (68.0–79.4) including the MARINA and ANCHOR trials [17,23,28,29,30,31]. Our results complement previous studies in other populations such as that of Oshima et al [17].…”

“…Our data show that treatment of nAMD significantly improves QoL regardless of clinical response and that this improvement is clinically significant with mean gains in NEI-VFQ 25 total scores exceeding the 4-point threshold established for nAMD [ 12 , 29 , 32 , 33 ]. Most of this improvement occurs during the loading phase, with slower gains during the extension phase.…”

Perceptual characteristics of scotomas modulate visual performance under simulated prosthetic vision

“…Taken together, these pilot results confirm that the VR-induced central occlusion was sufficient to increase the perceptual and attentional demands of the visual search task, consistent with the clinical literature on macular degeneration [63,64]. Given the limited sample size, no broad inferential conclusions are drawn from this comparison; it serves solely as a validation that the simulation platform produced the expected pattern of visual impairment.…”

Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

“…One limitation of the current study is that visual function was represented only by BCVA. Other clinical measurements, such as contrast sensitivity and reading speed, are also complementary to visual acuity in some aspects that affect quality of life,[ 20 ] and thus, it would strengthen our conclusion if these clinical measurements were included. In addition, the response rate for the driving subscale was only 6.25% in our study.…”

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

“…In our series, we found that the baseline NEI-VFQ-25 composite score in our population was 82.14, which is higher than the results of previous studies (68.0–79.4) including the MARINA and ANCHOR trials [17,23,28,29,30,31]. Our results complement previous studies in other populations such as that of Oshima et al [17].…”

“…Our data show that treatment of nAMD significantly improves QoL regardless of clinical response and that this improvement is clinically significant with mean gains in NEI-VFQ 25 total scores exceeding the 4-point threshold established for nAMD [ 12 , 29 , 32 , 33 ]. Most of this improvement occurs during the loading phase, with slower gains during the extension phase.…”

Perceptual characteristics of scotomas modulate visual performance under simulated prosthetic vision

“…Taken together, these pilot results confirm that the VR-induced central occlusion was sufficient to increase the perceptual and attentional demands of the visual search task, consistent with the clinical literature on macular degeneration [63,64]. Given the limited sample size, no broad inferential conclusions are drawn from this comparison; it serves solely as a validation that the simulation platform produced the expected pattern of visual impairment.…”

Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

“…One limitation of the current study is that visual function was represented only by BCVA. Other clinical measurements, such as contrast sensitivity and reading speed, are also complementary to visual acuity in some aspects that affect quality of life,[ 20 ] and thus, it would strengthen our conclusion if these clinical measurements were included. In addition, the response rate for the driving subscale was only 6.25% in our study.…”

Relationships between Patient-Reported Outcome Measures and Clinical Measures in Naïve Neovascular Age-Related Macular Degeneration Patients Treated with Intravitreal Ranibizumab

“…In our series, we found that the baseline NEI-VFQ-25 composite score in our population was 82.14, which is higher than the results of previous studies (68.0–79.4) including the MARINA and ANCHOR trials [17,23,28,29,30,31]. Our results complement previous studies in other populations such as that of Oshima et al [17].…”

“…Our data show that treatment of nAMD significantly improves QoL regardless of clinical response and that this improvement is clinically significant with mean gains in NEI-VFQ 25 total scores exceeding the 4-point threshold established for nAMD [ 12 , 29 , 32 , 33 ]. Most of this improvement occurs during the loading phase, with slower gains during the extension phase.…”

Perceptual characteristics of scotomas modulate visual performance under simulated prosthetic vision

“…Taken together, these pilot results confirm that the VR-induced central occlusion was sufficient to increase the perceptual and attentional demands of the visual search task, consistent with the clinical literature on macular degeneration [63,64]. Given the limited sample size, no broad inferential conclusions are drawn from this comparison; it serves solely as a validation that the simulation platform produced the expected pattern of visual impairment.…”

Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

“…One limitation of the current study is that visual function was represented only by BCVA. Other clinical measurements, such as contrast sensitivity and reading speed, are also complementary to visual acuity in some aspects that affect quality of life,[ 20 ] and thus, it would strengthen our conclusion if these clinical measurements were included. In addition, the response rate for the driving subscale was only 6.25% in our study.…”