Assay of ezlopitant, a substance P receptor antagonist, and metabolites in biological matrices by gas chromatography with mass spectrometric detection: simultaneous analysis of a benzyl alcohol and alkene

Reed-Hagen, Anne E.; Janiszewski, John; Cole, Roderic O.; Obach, R. Scott

doi:10.1016/s0378-4347(00)00252-8

Journal of Chromatography B: Biomedical Sciences and Applicatio

2000

DOI: 10.1016/s0378-4347(00)00252-8

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Assay of ezlopitant, a substance P receptor antagonist, and metabolites in biological matrices by gas chromatography with mass spectrometric detection: simultaneous analysis of a benzyl alcohol and alkene

Anne E. Reed-Hagen

John Janiszewski

Roderic O. Cole

et al.

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Cited by 4 publications

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Current Awareness

2000

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author (4 Weeks journals ‐ Search completed at 4th. Oct. 2000)

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Current Awareness

2000

J. Mass Spectrom.

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Linear programming of inlet pressure or flow-rate in isothermal gas chromatography with near-vacuum outlet pressure

Nahir

Gerbec

2001

Journal of Chromatography A

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Potential therapeutic targets for neurokinin-1 receptor antagonists

Duffy¹

2004

Expert Opinion on Emerging Drugs

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The peptide substance P and its tachykinin receptor, neurokinin-1 (NK1), have been the focus of considerable research for their role in a variety of both central and peripheral diseases. Recent preclinical data, as well as relevant clinical findings, support the potential therapeutic value of NK1 receptor antagonists in centrally mediated disease states, including anxiety and depression. In addition, a separate body of literature supports the use of NK1 receptor antagonists as inhibitors of centrally mediated emetic and cough responses. The role of NK1 receptor antagonists as analgesic agents with potential to treat migraine headache has also been investigated. NK1 receptors are also found in a number of peripheral regions, including the bladder, gastrointestinal tract and bone marrow. Preclinical models have been employed to address the potential therapeutic uses for NK1 receptor antagonists in diseases associated with inflammatory responses, including asthma, irritable bowel syndrome and cystitis of the bladder. Finally, other more recent publications suggest a role for NK1 receptor antagonists as tumour suppressants and haematopoietic agents. These applications for NK1 receptor antagonists are discussed in this review.

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Assay of ezlopitant, a substance P receptor antagonist, and metabolites in biological matrices by gas chromatography with mass spectrometric detection: simultaneous analysis of a benzyl alcohol and alkene

Cited by 4 publications

References 3 publications

Current Awareness

Current Awareness

Linear programming of inlet pressure or flow-rate in isothermal gas chromatography with near-vacuum outlet pressure

Potential therapeutic targets for neurokinin-1 receptor antagonists

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