Aspects épidémiologiques du kératocône chez l’enfant

Léoni-Mesplié, S.; Mortemousque, B.; Mesplié, N.; Touboul, David; Praud, Delphine; Malet, Florence; Colin, Joseph

doi:10.1016/j.jfo.2011.12.012

Cited by 35 publications

(8 citation statements)

References 80 publications

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“…Eye rubbing, hand palm compression, knuckle massage, or finger poking over a long period of time may cause significant corneal tissue responses not limited to direct mechanical injury to the collagen fibers but also impacting the cellular composition of the corneal tissue [6]. A significant association between eye rubbing and KC induction has been reported in numerous studies to date [7][8][9]10…”

Section: Mechanical Manipulationmentioning

confidence: 99%

The role of environment in the pathogenesis of keratoconus

Magalhães¹,

Gonçalves²,

Gatinel

2021

Current Opinion in Ophthalmology

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Purpose of reviewThis study was conducted to demonstrate the importance of the environment in keratoconus (KC) genesis. Recent findingsGenetic-related connective tissue disorders demonstrate the inconsistency of theories regarding KC pathogenesis since no corneal steepening was observed in the majority of these patients. Despite recent advances and decades of research into the genetics of KC, the identification of disease-causing KC genes has been frustrating. Variants found based on genome-wide and next-generation sequencing only seem to account for a small number of cases or play a limited role in KC pathogenesis.

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Section: Mechanical Manipulationmentioning

confidence: 99%

The role of environment in the pathogenesis of keratoconus

Magalhães¹,

Gonçalves²,

Gatinel

2021

Current Opinion in Ophthalmology

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“…These mediators include inflammatory molecules like histamine, proteases, tumor necrosis factor (TNF) -alpha, and interleukin (IL). [134568] Increased proteases, protease activity, and inflammatory molecules in the tears have been found to be relevant in the pathogenesis of KC. It has been proven that eye rubbing increases the level of tear matrix metalloproteinases (MMP)-13, IL-6, and TNF- alpha even in normal subjects.…”

Section: Review Of Literaturementioning

confidence: 99%

“…Léoni-Mesplié et al ., studied the epidemiological aspects of KC in 49 children and compared these with 167 adult patients. [8] They found that allergy as well as eye rubbing are more in children compared to adults (allergy; 67.3 versus 47.3% in adults and eye rubbing; 91.8 versus 70% in adults). The authors recommend that corneal topography should be performed routinely in all young, allergic boys with the history of eye rubbing and recent-onset corneal astigmatism.…”

Section: Review Of Literaturementioning

confidence: 99%

Ocular allergy and keratoconus

Sharma

Rao

Maharana

et al. 2013

Indian J Ophthalmol

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Keratoconus is the most common corneal ectatic disorder, the cause of which is largely unknown. Many factors have been implicated, and the ocular allergy is being one of them. The commonly proposed pathogenesis includes the release of inflammatory mediators due to eye rubbing which may alter the corneal collagen and lead to corneal ectasias. The onset of keratoconus is often early in cases associated with allergy and routine corneal topography may detect subtle forms of keratoconus. These cases may require early keratoplasty and are at an increased risk of having acute corneal hydrops. Surgical outcomes are similar to primary keratoconus cases. However, post-operative epithelial breakdown may be a problem in these cases. Control of allergy and eye rubbing is the best measure to prevent corneal ectasias in cases of ocular allergy.

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“…(12) É sabido que formas prematuras de ceratocone costumam ter um curso mais agressivo. (13) Assim, o objetivo deste estudo foi avaliar a possibilidade de alterações precoces sugestivas de ectasia detectáveis no Pentacam em casos sutis de alergia ocular em crianças MÉTODOS Trata-se de estudo retrospectivo em que foram analisados prontuários de 49 pacientes. Destes, 31 tinham diagnóstico de alergia ocular grau 1 de acordo com a classificação do Consenso Latino Americano de Alergia Ocular, sendo 22 do sexo masculino, com idades entre 3 a 14 anos, e 18 pacientes, sendo 12 meninas, com idades entre 6 e 12 anos, não tinham alterações oftalmológicas ou diagnóstico de alergia ocular e serviram como grupo controle.…”

Section: Introductionunclassified