Aspectos químicos e biológicos do gênero Lippia enfatizando Lippia gracilis Schauer

Gomes, Silvana Vieira Floresta; Nogueira, Paulo C.L.; Moraes, Valéria R. S.

doi:10.26850/1678-4618eqj.v36.1.2011.p64-77

Cited by 7 publications

(1 citation statement)

References 42 publications

(42 reference statements)

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“…Thymol (2-isopropyl-5-methylphenol) is a major constituent of the essential oils from plants of the genus Lippia and Thymis (GOMES et al, 2011;ELANDALOUSI et al, 2013) and presents in vitro anthelmintic activity on H. contortus (CAMURÇA-VASCONCELOS et al 2007;ELANDALOUSI et al, 2013;FERREIRA et al, 2016). It is a phenolic compound causing high toxicity due to the presence of the hydroxyl radical.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice

André

Cavalcante

Ribeiro

et al. 2017

Rev. Bras. Parasitol. Vet.

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Thymol is a monoterpene and acetylation form of this compound can reduce the toxicity and enhance its biological effects. The objective of this study was to evaluate the effect of thymol and thymol acetate (TA) on egg, larva and adult Haemonchus contortus and the cuticular changes, acute toxicity in mice and the efficacy on sheep gastrointestinal nematodes. In vitro tests results were analyzed by analysis of variance (ANOVA) and followed by comparison with Tukey test or Bonferroni. The efficacy of in vivo test was calculated by the BootStreet program. In the egg hatch test (EHT), thymol (0.5 mg/mL) and TA (4 mg/mL) inhibited larval hatching by 98% and 67.1%, respectively. Thymol and TA (8 mg/mL) inhibited 100% of larval development. Thymol and TA (800 µg/mL) reduced the motility of adult worms, by 100% and 83.4%, respectively. Thymol caused cuticular changes in adult worm teguments. In the acute toxicity test, the LD 50 of thymol and TA were 1,350.9 mg/kg and 4,144.4 mg/kg, respectively. Thymol and TA reduced sheep egg count per gram of faeces (epg) by 59.8% and 76.2%, respectively. In in vitro tests thymol presented better anthelmintic activity than TA. However TA was less toxic and in in vivo test efficacy was similar.Keywords: Acetylation, thymol, Haemonchus contortus, nematodes, sheep. ResumoTimol é um monoterpeno e a acetilação deste composto pode reduzir a toxicidade e potencializar os seus efeitos biológicos. O objetivo deste trabalho foi avaliar o efeito do timol e acetato de timolila (AT) sobre ovos, larvas e adultos de Haemonchus contortus e suas alterações cuticulares, toxicidade aguda em camundongos e a eficácia sobre nematoides gastrintestinais de ovinos. Os resultados dos testes in vitro foram analisados por análise de variância (ANOVA) e comparados pelo testes de Tukey ou Bonferroni. A eficácia do teste de redução da contagem de ovos nas fezes (RCOF) foi calculada pelo programa BootStreet. No teste de inibição da eclosão de ovos (TEO), timol (0,5 mg/mL) e AT (4 mg/mL) inibiram a eclosão das larvas em 98% e 67,1%, respectivamente. Timol e AT (8 mg/mL) inibiram 100% do desenvolvimento larval. Timol e AT (800 µg/mL) reduziram a motilidade dos nematoides adultos, em 100% e 83,4%, respectivamente. O timol provocou alterações cuticulares nos nematoides adultos. No teste de toxicidade aguda, a DL50 do timol e AT foi de 1.350,9 mg/kg e 4.144,4 mg/kg, respectivamente. Timol e AT reduziram a contagem de ovos por gramas de fezes (OPG) dos ovinos em 59,8% e 76,2%, respectivamente. Nos testes in vitro timol apresentou atividade melhor anti-helmíntica do que AT. Entretanto, AT foi menos tóxico do que o timol e no teste in vivo apresentaram eficácia semelhante.

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Section: Introductionmentioning

confidence: 99%

Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice

André

Cavalcante

Ribeiro

et al. 2017

Rev. Bras. Parasitol. Vet.

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Insecticidal activity of essential oils of species from the genus Lippia against Nasutitermes corniger (Motschulsky) (Isoptera: Termitidae)

Santos¹,

Oliveira²,

Lucchese³

et al. 2020

Sociobiology

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Lippia is one of the main genera in the family Verbenaceae, with 200 species described. Despite its richness in bioactive molecules, with several scientifically proven applications, there is little information on the insecticidal potential of its species. This study aimed to assess the insecticidal potential of essential oils from the species Lippia thymoides (Martius & Schauer); Lippia lasiocalycina (Schauer) and Lippia insignis (Moldenk) against Nasutitermes corniger (Motschulsky) (Isoptera-Termitidae). Insecticidal activity was evaluated by exposure to a contaminated surface, whereby plastic pots were lined with filter paper and imbibed in 1.5 ml of solution containing essential oils (10 µl/ml), with 10 N. corniger specimens per pot. The mortality count was performed at 24 and 48 h. The LC50 was determined by diluting the essential oils to concentrations of 0, 0.625, 1.25, 2.5, 5.0 and 10 µl/ml, which were chemically analyzed by GC-FID and GC-MS. The data indicated high toxicity for the essential oils for the Lippia species tested. The lowest LC50 (0.46 µl/ml) was recorded for L. lasiocalycina. The most common constituents were β-myrcene and (E)-ocimenone in essential oil of L. lasiocalycina, β-myrcene and limonene for L. insignis, and (E)-caryophyllene and caryophyllene oxide for L. thymoides. The results demonstrate the viability of developing biopesticides for N. corniger control.

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Aplicação de óleos essenciais no controle alternativo da antracnose no Brasil

Rodrigues

Bossi

Dranka

et al. 2021

Metapre

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O uso descontrolado de agrotóxicos em lavouras nos sistemas de produção agrícola nos impulsionou a buscar por medidas alternativas no controle de doença fúngica de potencial relevante como é o caso da antracnose em lavouras de banana e de maracujá, tornando estas medidas de controle menos agressivas ao meio ambiente e ao ser humano. Neste contexto, o trabalho teve como objetivo reunir publicações com potencial antifúngico de óleos essenciais no controle alternativo de Colletotrichum sp.

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Aspectos químicos e biológicos do gênero Lippia enfatizando Lippia gracilis Schauer

Cited by 7 publications

References 42 publications

Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice

Anthelmintic effect of thymol and thymol acetate on sheep gastrointestinal nematodes and their toxicity in mice

Insecticidal activity of essential oils of species from the genus Lippia against Nasutitermes corniger (Motschulsky) (Isoptera: Termitidae)

Aplicação de óleos essenciais no controle alternativo da antracnose no Brasil

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