Asian age‐related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study

Abstract

This study will provide in-depth longitudinal data of the evolution of clinical features, risk factors, natural history and treatment pattern and response of Asian AMD and polypoidal choroidovasculopathy, allowing unique insights into pathogenesis and the design of new treatment strategies.

Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans

“…Detailed study protocol has been published previously1162839. All patients provided written informed consent to participate in this research.…”

“…Second, nAMD in Asians is also often divided into typical AMD with clinical features similar to those seen in Western populations, and polypoidal choroidal vasculopathy (PCV)12829. Whether these two subtypes are associated with different risk factors remains unclear.…”

“…To this end, we designed the Asian AMD Phenotyping Study in 2010 with the aim to study the clinical features and risk factors of Asian nAMD, including further subtyping into typical AMD and PCV according to angiographic features in every case. To facilitate comparison of potential risk factors, the Asian AMD Phenotyping study adopted methods modelled after the Singapore Epidemiology of Eye Disease program which enrolled >10,000 participants using standardized methodology and photographic grading for AMD and risk factor assessment28. In this report, we performed case-control comparison of risk factors between 456 patients with nAMD and 1,824 controls free of AMD who were matched for age, gender and ethnicity.…”

Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration

“…It aims to provide longitudinal data on the clinical features, risk factors, natural history, treatment pattern and response, and QoL impact of nAMD 12. The Asian AMD Phenotyping Study adhered to the tenets of the Declaration of Helsinki, and all patients provided written informed consent.…”

The impact of typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy on vision-related quality of life in Asian patients

“…The Asian AMD Phenotyping Study is a prospective clinical study of Asian patients in Singapore that aims to provide longitudinal data on the clinical features, risk factors, natural history, treatment pattern and response, and QoL impact of nAMD 9. Patients with nAMD who had received no treatment for macular diseases in the last 12 months were recruited from a public outpatient retinal clinic of a major Singapore hospital.…”