Aseptic peritonitis due to peptidoglycan contamination of pharmacopoeia standard dialysis solution

MARTIS, L; PATEL, M; GIERTYCH, J; MONGOVEN, J; TAMINNE, M; PERRIER, M; MENDOZA, O; Goud, N.S.; COSTIGAN, A; DENJOY, N

doi:10.1016/s0140-6736(05)70800-x

Cited by 68 publications

(38 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Being specific for endotoxins therefore precludes the Bet from being a complete alternative to the RPt (Martis et al, 2005;Huang et al, 2009) because NeP contaminations that are not detectable by this test may cause severe clinical signs.…”

Section: In Mononuclear Cells When the 4/2 Acyl Chain Pattern Of Entementioning

confidence: 99%

“…(eU, 2010) As a true pyrogen test, the RPt is considered to be able to detect endotoxin and non-endotoxin pyrogens (NePs) alike (Nakagawa et al, 2002); in some cases, however, the RPt remains negative in response to NeP that induce pyrogenic adverse reactions in humans (Martis et al, 2005).…”

Section: The Rabbit Pyrogen Test (Rpt)mentioning

confidence: 99%

“…Martis et al (2005) investigated the patients' reports and the incriminated batches. the complaint batches did not produce a signal in the lAl assay, nor did they show a body temperature rise in rabbits.…”

Section: Tab 4: Incriminated Infusion Solution Containing Gelatinmentioning

confidence: 99%

See 2 more Smart Citations

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Hasiwa

Daneshian

Bruegger

et al. 2013

ALTEX

View full text Add to dashboard Cite

show abstract

Section: In Mononuclear Cells When the 4/2 Acyl Chain Pattern Of Entementioning

confidence: 99%

Section: The Rabbit Pyrogen Test (Rpt)mentioning

confidence: 99%

See 1 more Smart Citation

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Hasiwa

Daneshian

Bruegger

et al. 2013

ALTEX

View full text Add to dashboard Cite

show abstract

“…Although sensitivity was suboptimal, the results would suggest a good negative predictive value and therefore a possible role for this assay in excluding bacterial infection from PDAP. A negative PCR result would then encourage clinicians to look for other possible causes of a raised WCC, such as endotoxin [17] or malignancy, and perform a cytological examination of the peritoneal fluid to determine the new diagnosis [18]. Clinicians should also consider the possibility of other infectious agents, which would not be detected by the 16S rDNA PCR or standard culture, such as a slow growing fungus or Mycobacterium sp.…”

Section: Discussionmentioning

confidence: 99%

The Role of 16s rDNA PCR in the Diagnosis of Peritoneal Dialysis-Associated Peritonitis

Collier¹

2012

J Med Microb Diagn

View full text Add to dashboard Cite

Introduction: Despite recent advances in peritoneal dialysis (PD), peritonitis remains the most common and serious complication. In a significant proportion of patients a pathogen is not cultured. In this study we investigated the use of 16S rDNA PCR to make a bacterial diagnosis. Methods:We used an optimised DNA extraction and 16S rDNA PCR with DNA sequencing to detect pathogens in peritoneal dialysis-associated peritonitis (PDAP).Results: Seventy-one PD fluids from twenty-four patients were analysed. In suspected cases of PDAP, thirteen out of twenty-one patients had a bacterial pathogen cultured and 16S rDNA PCR with DNA sequencing identified one additional pathogen. However 16S rDNA PCR only detected the pathogen in five of the culture-positive fluids. All follow-up samples were culture-negative, but possible pathogens were identified in three samples by the 16S rDNA PCR.In suspected cases of PDAP the sensitivity and specificity of the PCR was calculated as 69% and 63%, respectively. Conclusion:The use of 16S rDNA PCR in diagnosing PDAP needs further study and improved sensitivity before widespread introduction.

show abstract

“…bacteria remains the prototypic pyrogen, substances such as Iipoteichoic acid (LTA) and peptidoglycan from Gram-positive bacteria and others are increasingly recognized as potent immune stimuli (Morath et al, 2001;Schindler et al, 2003;Martis et al, 2005). The presence of pyrogens in the body initiates secretion of pro-inflammatory cytokines by monocytes .…”

Section: Introductionmentioning

confidence: 99%

In vitro pyrogen test for toxic or immunomodulatory drugs

Daneshian

Guenther

Wendel

et al. 2006

Journal of Immunological Methods

View full text Add to dashboard Cite

Pyrogenic contaminations of some classes of injectable drugs, e.g , tox ic or immunomodulatory as well as false-positive drugs, represent a major risk which cannot yet be excluded due to the limitations of current tests . Here we describe a modification of the In vitro Pyrogen Test termed AWIPT (Adsorb, Wash, In vitro Pyrogen Test), which addresses this problem by introducing a preincubation step in which pyrogenic contaminations in the test sample are adsorbed to albumin-coated beads. After rinsing, the beads are incubated with human whole blood and the release of the endogenous pyrogen interleukin-I~is measured as a marker of pyrogenic activity. Intentional contaminations with lipopolysaccharide were retrieved from the chemotherapeutic agents paclitaxel, cisplatin and liposomal daunorubicin, the antibiotic gentamicin, the antifungal agent liposomal amphotericin B, and the cort icosteroid prednisolone at lower dilut ions than in the standard in vitro pyrogen test. This represents a promising new approach for the detection of pyrogenic contamination in drugs or in drugs containing interfering additives and should lead to improved safety levels .

show abstract

Aseptic peritonitis due to peptidoglycan contamination of pharmacopoeia standard dialysis solution

Cited by 68 publications

References 0 publications

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

Evidence for the detection of non-endotoxin pyrogens by the whole blood monocyte activation test

The Role of 16s rDNA PCR in the Diagnosis of Peritoneal Dialysis-Associated Peritonitis

In vitro pyrogen test for toxic or immunomodulatory drugs

Contact Info

Product

Resources

About