Ascending efferent projections of the superior olivary complex

Oliver, Douglas L.

doi:10.1002/1097-0029(20001115)51:4<355::aid-jemt5>3.0.co;2-j

Cited by 94 publications

(37 citation statements)

References 71 publications

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“…The synaptic domain hypothesis predicts the brainstem inputs to the ICC cluster into zones with common anatomic input and similar sounds preference (Oliver, 2000; Loftus et al, 2010). Here, we have demonstrated that neurons are highly localized into functional zones with similar spectrotemporal sensitivity, supporting the domain hypothesis organization within the ICC.…”

Section: Discussionmentioning

confidence: 99%

“…Three organization principles for brainstem input to the central nucleus of inferior colliculus (ICC) are the basis of the “synaptic domain hypothesis” that predicts a division of ICC into synaptic and functional domains with unique sound processing capability (Oliver, 2000; Loftus et al, 2010). First, tonotopically organized inputs from the brainstem project onto banded anatomical lamina with spatially restricted dendritic arbors and common best frequency (BF), that in the cat can extend across a ~3.5 × 3.5 mm 2 area (Morest and Oliver, 1984; Oliver and Morest, 1984; Serviere et al, 1984; Malmierca et al, 1993; Brown et al, 1997; Schreiner and Langner, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…First, tonotopically organized inputs from the brainstem project onto banded anatomical lamina with spatially restricted dendritic arbors and common best frequency (BF), that in the cat can extend across a ~3.5 × 3.5 mm 2 area (Morest and Oliver, 1984; Oliver and Morest, 1984; Serviere et al, 1984; Malmierca et al, 1993; Brown et al, 1997; Schreiner and Langner, 1997). Second, there is considerable convergence of different brainstem nuclei as well as different neuronal cell types onto a given frequency lamina that could allow for genesis of novel sound response properties (Adams, 1979; Oliver, 2000; Malmierca et al, 2005; Loftus et al, 2010). Third, brainstem projections are not uniformly distributed throughout all frequency laminae or even within a single frequency lamina (Oliver, 2000; Malmierca et al, 2005; Cant and Benson, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Second, there is considerable convergence of different brainstem nuclei as well as different neuronal cell types onto a given frequency lamina that could allow for genesis of novel sound response properties (Adams, 1979; Oliver, 2000; Malmierca et al, 2005; Loftus et al, 2010). Third, brainstem projections are not uniformly distributed throughout all frequency laminae or even within a single frequency lamina (Oliver, 2000; Malmierca et al, 2005; Cant and Benson, 2008). These three anatomic patterns of pathway input to the ICC suggest a division of ICC into domains that process distinct sound features.…”

Section: Introductionmentioning

confidence: 99%

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Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Chen¹,

Rodríguez²,

Read³

et al. 2012

Front. Neural Circuits

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How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and temporal response preferences were compared for neurons found on the same and adjacent tetrodes (ATs), as well as across distant recording sites. We found that neighboring neurons had similar preferences while neurons recorded across distant sites were less similar. Best frequency (BF) was the most correlated parameter between neighboring neurons and BF differences exhibited unique clustering at ~0.3 octave intervals, indicative of the frequency band lamina. Other spectral and temporal parameters of the receptive fields were more similar for neighboring neurons than for those at distant sites and the receptive field similarity was larger for neurons with small differences in BF. Furthermore, correlated firing was stronger for neighboring neuron pairs and increased with proximity and decreasing BF difference. Thus, although response selectivities are quite diverse in the IC, spectral, and temporal preference within a local microcircuit are functionally quite similar. This suggests a scheme where local circuits are organized into zones that are specialized for processing distinct spectrotemporal cues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Chen¹,

Rodríguez²,

Read³

et al. 2012

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

“…A primary, ‘tonotopic’ map of best frequency (BF) is created by fibrodendritic laminae (Morest and Oliver, 1984; Oliver and Morest, 1984) and distributed from low frequency, dorsolaterally, to high frequency, ventromedially (Schreiner and Langner, 1997; Malmierca et al, 2005; Loftus et al, 2008; Malmierca et al). A secondary ‘nucleotopic’ organization (Brunso-Bechtold et al, 1981) subdivides the ICC into synaptic domains or functional zones that receive inputs from a particular brainstem nucleus or nuclei (Aitkin and Schuck, 1985; Maffi and Aitkin, 1987; Shneiderman and Henkel, 1987; Oliver and Huerta, 1992; Oliver, 2000; Oliver, 2005; Cant and Benson, 2006). …”

Section: Introductionmentioning

confidence: 99%

Differential Patterns of Inputs Create Functional Zones in Central Nucleus of Inferior Colliculus

Loftus

Bishop²,

Oliver³

2010

J. Neurosci.

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Distinct pathways carry monaural and binaural information from the lower auditory brainstem to the central nucleus of the inferior colliculus (ICC). Previous anatomical and physiological studies suggest that differential ascending inputs to regions of the ICC create functionally distinct zones. Here, we provide direct evidence of this relationship by combining recordings of single unit responses to sound in the ICC with focal, iontophoretic injections of the retrograde tracer Fluoro-Gold at the physiologically characterized sites. Three main patterns of anatomical inputs were observed. One pattern was identified by inputs from the cochlear nucleus and ventral nucleus of the lateral lemniscus in isolation, and these injection sites were correlated with monaural responses. The second pattern had inputs only from the ipsilateral medial and lateral superior olive, and these sites were correlated with interaural time difference (ITD)-sensitive responses to low frequency (Ͻ500 Hz). A third pattern had inputs from a variety of olivary and lemniscal sources, notably the contralateral lateral superior olive and dorsal nucleus of the lateral lemniscus. These were correlated with high-frequency ITD sensitivity to complex acoustic stimuli. These data support the notion of anatomical regions formed by specific patterns of anatomical inputs to the ICC. Such synaptic domains may represent functional zones in ICC.

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Alterations in calretinin immunostaining in the ferret superior olivary complex after cochlear ablation

Alvarado

Fuentes–Santamaría

Henkel

et al. 2004

J of Comparative Neurology

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In this study, we used image analysis to assess changes in calretinin immunoreactivity in the lateral (LSO) and medial (MSO) superior olivary nuclei in ferrets 2 months after unilateral cochlear ablations at 30-40 days of age, soon after hearing onset. These two nuclei are the first significant sites of binaural convergence in the ascending auditory system, and both receive direct projections from the deafferented cochlear nucleus. Cochlear ablation results in a decrease in the overall level of calretinin immunostaining within the LSO ipsilaterally compared with the contralateral side and with control animals and within the MSO bilaterally compared with control ferrets. In addition, the level of calretinin immunostaining ipsilaterally within neurons in the LSO was significantly less in cochlear ablated than control animals. In contrast, there was no effect of cochlear ablation on the level of calretinin immunostaining within neurons either in the contralateral LSO or in the MSO. These results are consistent with a downregulation in calretinin within the neuropil of MSO bilaterally and LSO ipsilaterally, as well as a downregulation in calretinin within somata in the ipsilateral LSO as a result of unilateral cochlear ablation soon after hearing onset. Thus, cochlear-driven activity appears to affect calcium binding protein levels in both neuropil and neurons within the superior olivary complex.

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Ascending efferent projections of the superior olivary complex

Cited by 94 publications

References 71 publications

Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

Differential Patterns of Inputs Create Functional Zones in Central Nucleus of Inferior Colliculus

Alterations in calretinin immunostaining in the ferret superior olivary complex after cochlear ablation

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