Asbestos: use, bans and disease burden in Europe

Kameda, Takashi; Takahashi, Ken; Kim, Rokho; Jiang, Ying; Movahed, Mehrnoosh; Park, Eun-Kee; Rantanen, Jorma

doi:10.2471/blt.13.132118

Cited by 87 publications

(79 citation statements)

References 14 publications

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“…2 Asbestos exposure causes 6 to 23% of all male lung cancers (estimates depending on the exposure and population), and >107,000 deaths annually from asbestosrelated diseases. 3,4 All forms of asbestos are carcinogenic to …”

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confidence: 99%

Asbestos‐associated genome‐wide DNA methylation changes in lung cancer

Kettunen

Hernandez-Vargas

Cros

et al. 2017

Intl Journal of Cancer

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Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Illumina HumanMethylation450K BeadChip) of lung cancer tissue and paired normal lung from 28 asbestos-exposed or non-exposed patients, mostly smokers, revealed distinctive DNA methylation changes. We identified a number of differentially methylated regions (DMR) and differentially variable, differentially methylated CpGs (DVMC), with individual CpGs further validated by pyrosequencing in an independent series of 91 non-small cell lung cancer and paired normal lung. We discovered and validated BEND4, ZSCAN31 and GPR135 as significantly hypermethylated in lung cancer. DMRs in genes such as RARB (FDR 1.1 3 10 219 , mean change in beta [D] 20.09), GPR135 (FDR 1.87 3 10 28 , mean D 20.09) and TPO (FDR 8.58 3 10 25 , mean D 20.11), and DVMCs in NPTN, NRG2, GLT25D2 and TRPC3 (all with p <0.05, t-test) were significantly associated with asbestos exposure status in exposed versus non-exposed lung tumors. Hypomethylation was characteristic to DVMCs in lung cancer tissue from asbestos-exposed subjects. When DVMCs related to asbestos or smoking were analyzed, 96% of the elements were unique to either of the exposures, consistent with the concept that the methylation changes in tumors may be specific for risk factors. In conclusion, we identified novel DNA methylation changes associated with lung tumors and asbestos exposure, suggesting that changes may be present in causal pathway from asbestos exposure to lung cancer.Lung cancer is the leading cause of cancer-related deaths, accounting for around every fifth global cancer death. 1 While tobacco smoking remains the principal risk factor for lung carcinogenesis, exposure to asbestos, a group of naturally occurring fibrous silicate minerals with multiple commercial applications, is the most important occupational risk factor for lung cancer. 2 Asbestos exposure causes 6 to 23% of all male lung cancers (estimates depending on the exposure and population), and >107,000 deaths annually from asbestosrelated diseases. 3,4 All forms of asbestos are carcinogenic to

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mentioning

confidence: 99%

Asbestos‐associated genome‐wide DNA methylation changes in lung cancer

Kettunen

Hernandez-Vargas

Cros

et al. 2017

Intl Journal of Cancer

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“…While historically exposure was high during mining and manufacturing or while dusty sawing, drilling, grinding and installing asbestos containing material, today's exposure is quite low with proper disposal [4][5][6]. Nevertheless, unless asbestos is being banned around the globe, asbestos diseases are bound to persist [5,7] and people will die [8]. As exposure cessation for insureds dates back up to the 60s the traceability of asbestos fibers in lung tissue after this long latency period is of significance for the diagnosis of asbestosis and occupational compensation.…”

Section: Introductionmentioning

confidence: 99%

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Feder

Theile

Tannapfel

2017

Int J Occup Med Environ Health

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Objectives: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. Material and Methods: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings. Results: For 68 insured persons, recognition of an asbestos-induced lung disease according to Section 4104 of the German Ordinance on Occupational Diseases (Berufskrankheitenverordnung -BKV) could be recommended solely on the basis of the histological examinations of lung tissues and complementary lung dust analyses. Neither did the calculation of the cumulative asbestos dust exposure at work yield 25 fiber years, nor could bridge findings (e.g., plaques) be identified. In addition, the autopsies of 12 patients revealed plaques that had not been diagnosed during radiological examinations. These results show that -irrespective of the prescribed working techniques and radiological diagnosis -pathological/anatomical and histological diagnostics are often the only way for the insureds to demonstrate the causal connection between asbestos and their disease. Even after long intervals of up to 40 years post last exposure, the asbestos fibers would still be easily detectable in the lung tissues evaluated. Conclusions: Whenever suitable tissue is available, it should be examined for mild asbestosis with the aid of a lung dust analysis. Otherwise there is a risk that an occupational disease is wrongfully rejected. In the context of health insurance, the lung dust analysis and the resulting proof of the presence of asbestosis often constitute one option of providing evidence of an occupational disease. Int J Occup Med Environ Health 2018;31(3):293 -305

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“…Dessa forma, a exposição ao amianto se tornou uma urgência sanitária, pelos riscos eminentes à saúde da população adulta (16) .…”

Section: Introductionunclassified

Impacto Da Exposição Ao Amianto Na Saúde Da População Adulta: Revisão Integrativa

2016

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Objetivou-se identificar o impacto da exposição ao amianto na saúde da população adulta, nas publicações científicas. Revisão Integrativa de literatura realizada em bases de dados na área da saúde no período de 2005 a 2015. Foram selecionados 15 estudos. Verificou-se o impacto da exposição ao amianto na população adulta com o adoecimento por mesotelioma maligno, asbestose, câncer de pulmão, entre outros; a mortalidade por mesotelioma em trabalhadores conferiu prevalência significativa para o estudo. A taxa mortalidade é preocupante, haja visto que as possibilidades terapêuticas são limitadas. O impacto do amianto ultrapassa os aspectos biológicos, trazendo alterações psicoemocionais significativas na saúde da população. Destaca-se a importância do debate sobre o impacto do amianto na saúde do adulto, principalmente no campo da saúde do trabalhador sobre a necessidade do banimento de seu uso nos países que o mantém em escala industrial e comercial.

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Asbestos: use, bans and disease burden in Europe

Cited by 87 publications

References 14 publications

Asbestos‐associated genome‐wide DNA methylation changes in lung cancer

Asbestos‐associated genome‐wide DNA methylation changes in lung cancer

Histological findings and lung dust analysis as the basis for occupational disease compensation in asbestos-related lung cancer in Germany

Impacto Da Exposição Ao Amianto Na Saúde Da População Adulta: Revisão Integrativa

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