Aryl Rings Are Part of the Darpone Pharmacophore

Schultz, Christiane; Link, Andreas; Kunick, Conrad

doi:10.1002/1521-4184(200105)334:5<163::aid-ardp163>3.3.co;2-v

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2009

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“…To this end, saponification of ethyl ester 9 was readily accomplished by treatment with potassium trimethylsilanolate giving acid 17 in 90% yield (vide infra). The decarboxylation step is classically accomplished by strong heating either neat or in the presence of copper powder or copper/quinoline . Unfortunately, none of these decarboxylation methods proved successful and returned only the carboxylic acid 17 .…”

Section: Resultsmentioning

confidence: 99%

Synthesis of the Louisianin Alkaloid Family via a 1,2,4-Triazine Inverse-Electron-Demand Diels−Alder Approach

et al. 2009

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Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin family, from a conveniently prepared 1,2,4-triazine and via a common tetrasubstituted pyridine intermediate. This study includes the synthesis of louisianin B in both racemic form and as the (-)-enantiomer.

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Section: Resultsmentioning

confidence: 99%