Artificial membranes with selective nanochannels for protein transport

Sutisna, Burhannudin; Polymeropoulos, George; Mygiakis, Emmanouil; Musteata, Valentina-Elena; Peinemann, Klaus‐Viktor; Smilgies, Detlef‐M.; Hadjichristidis, Nikos; Nunes, Suzana Pereira

doi:10.1039/c6py01401a

Cited by 21 publications

(33 citation statements)

References 75 publications

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“…Such functional groups can create selective nanochannels, which exhibit special interaction (e.g., hydrogen bonding, electrostatic interactions, etc.) with molecules passing through the membranes to perform separations that cannot be done by conventional membranes, as previously demonstrated by our group, using a block copolymer containing hydrogen bonds sites . In addition, the increased hydrophilicity of the membranes after modification can be beneficial to improve the antifouling properties of the membranes.…”

Section: Resultsmentioning

confidence: 80%

“…with molecules passing through the membranes to perform separations that cannot be done by conventional membranes, as previously demonstrated by our group, using a block copolymer containing hydrogen bonds sites. [17] In addition, the increased hydrophilicity of the membranes after modification can be beneficial to improve the antifouling properties of the membranes. Our approach can open the avenue to develop robust nanofiltration membranes, having a sharp selectivity in the sub-nanometer range, in addition to another interesting approach using postpore functionalization, recently demonstrated by Zhang et al [29] On the other hand, isoporous hydrophobic block copolymer membranes have been rarely reported before and therefore new applications can profit from this class of membranes.…”

Section: Membrane Modificationmentioning

confidence: 99%

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Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Sutisna

Polymeropoulos

Musteata

et al. 2017

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Membranes are prepared by self-assembly and casting of 5 and 13 wt% poly(styrene-b-butadiene-b-styrene) (PS-b-PB-b-PS) copolymers solutions in different solvents, followed by immersion in water or ethanol. By controlling the solution-casting gap, porous films of 50 and 1 µm thickness are obtained. A gradient of increasing pore size is generated as the distance from the surface increased. An ordered porous surface layer with continuous nanochannels can be observed. Its formation is investigated, by using time-resolved grazing incident small angle X-ray scattering, electron microscopy, and rheology, suggesting a strong effect of the air-solution interface on the morphology formation. The thin PS-b-PB-b-PS ordered films are modified, by promoting the photolytic addition of thioglycolic acid to the polybutadiene groups, adding chemical functionality and specific transport characteristics on the preformed nanochannels, without sacrificing the membrane morphology. Photomodification increases fivefold the water permeance to around 2 L m h bar , compared to that of the unmodified one. A rejection of 74% is measured for methyl orange in water. The membranes fabrication with tailored nanochannels and chemical functionalities can be demonstrated using relatively lower cost block copolymers. Casting on porous polyacrylonitrile supports makes the membranes even more scalable and competitive in large scale.

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Section: Resultsmentioning

confidence: 80%

Section: Membrane Modificationmentioning

confidence: 99%

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Sutisna

Polymeropoulos

Musteata

et al. 2017

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“…Ultrapure water was used as the probing liquid, and the mean values were determined from five different independent specimens. The surface zeta potential was measured in a Nano Zetasizer surface cell cuvette containing trace particles (Nano ZS Zen3600, Malvern, UK) at pH 7 and 25 °C, as described elsewhere 18 .…”

Section: Membrane Characterizationmentioning

confidence: 99%

Removal of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes Affected by Varying Degrees of Fouling on Anaerobic Microfiltration Membranes

Cheng

Hong

2017

Environ. Sci. Technol.

107

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An anaerobic membrane bioreactor was retrofitted with polyvinylidene fluoride (PVDF) microfiltration membrane units, each of which was fouled to a different extent. The membranes with different degrees of fouling were evaluated for their efficiencies in removing three antibiotic-resistant bacteria (ARB), namely, bla-positive Escherichia coli PI-7, bla-positive Klebsiella pneumoniae L7, and bla-positive E. coli UPEC-RIY-4, as well as their associated plasmid-borne antibiotic resistance genes (ARGs). The results showed that the log removal values (LRVs) of ARGs correlated positively with the extent of membrane fouling and ranged from 1.9 to 3.9. New membranes with a minimal foulant layer could remove more than 5 log units of ARB. However, as the membranes progressed to subcritical fouling, the LRVs of ARB decreased at increasing operating transmembrane pressures (TMPs). The LRV recovered back to 5 when the membrane was critically fouled, and the achieved LRV remained stable at different operating TMPs. Furthermore, characterization of the surface attributed the removal of both the ARB and ARGs to adsorption, which was facilitated by an increasing hydrophobicity and a decreasing surface ζ potential as the membranes fouled. Our results indicate that both the TMP and the foulant layer synergistically affected ARB removal, but the foulant layer was the main factor that contributed to ARG removal.

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“…It has been reported in the literature that the addition of dioxane (DOX) in the mixture of THF-DMF reduces the solvent quality of the polar block [32]. Therefore, ternary solvent mixtures At this point it should be mentioned that the open porous membrane surface structure is a combined result of the strongly amphiphilic character of the block copolymer, which is a prerequisite to be very selective in the interaction with the involved solvents and the solvent-induced phase separation.…”

Section: Membrane Formation Via Snipsmentioning

confidence: 99%

“…It has been reported in the literature that the addition of dioxane (DOX) in the mixture of THF-DMF reduces the solvent quality of the polar block [32]. Therefore, ternary solvent mixtures THF/DMF/DOX for ratios 1/1/1 and 2/1/1, respectively, were studied for their effect on the membrane formation of the PS 81 -PGMA 19 128 diblock copolymers.…”

Section: Membrane Formation Via Snipsmentioning

confidence: 99%

Block Copolymer Membranes from Polystyrene-b-poly(solketal methacrylate) (PS-b-PSMA) and Amphiphilic Polystyrene-b-poly(glyceryl methacrylate) (PS-b-PGMA)

et al. 2017

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Abstract:In this paper; we compare double hydrophobic polystyrene-b-poly(solketal methacrylate) (PS-b-PSMA) and amphiphilic polystyrene-b-poly(glyceryl methacrylate) (PS-b-PGMA) diblock copolymer membranes which are prepared by combining the block copolymer self-assembly in solution with a non-solvent induced phase separation (SNIPS). Diblock copolymers (i.e., PS-b-PSMA) were synthesized by sequential living anionic polymerization, whereas polystyrene-b-poly(glyceryl methacrylate) (PS-b-PGMA) were obtained by acid hydrolysis of the acetonide groups of the polysolketal methacrylate (PSMA) blocks into dihydroxyl groups (PGMA). Membrane structures and bulk morphologies were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM); respectively. The resulting PS-b-PGMA diblock copolymers produce an ordered hexagonal cylindrical pore structure during the SNIPS process, while membranes fabricated from the double hydrophobic (PS-b-PSMA) do not under similar experimental conditions. Membrane performance was evaluated by water flux and contact angle measurements.

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Artificial membranes with selective nanochannels for protein transport

Abstract: CitationSutisna B, Polymeropoulos G, Mygiakis E, Musteata V, Peinemann K-V, et al. (2016) Our results demonstrate that artificial channels can be designed for protein transport via block copolymer self--assembly using classical methods of membranes preparation. text goes here.

Cited by 21 publications

References 75 publications

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Functionalized Nanochannels from Self‐Assembled and Photomodified Poly(Styrene‐b‐Butadiene‐b‐Styrene)

Removal of Antibiotic-Resistant Bacteria and Antibiotic Resistance Genes Affected by Varying Degrees of Fouling on Anaerobic Microfiltration Membranes

Block Copolymer Membranes from Polystyrene-b-poly(solketal methacrylate) (PS-b-PSMA) and Amphiphilic Polystyrene-b-poly(glyceryl methacrylate) (PS-b-PGMA)

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