Artificial Intelligence‐Supported Video Analysis as a Means to Assess the Impact of DROP‐IN Image Guidance on Robotic Surgeons: Radioguided Sentinel Lymph Node versus PSMA‐Targeted Prostate Cancer Surgery

Azargoshasb, Samaneh; Barros, Hilda A. de; Rietbergen, Daphne D. D.; Dell’Oglio, Paolo; Leeuwen, Pim J. van; Wagner, Christian von; Stricker, Phillip D.; Vidal-Sicart, Sergi; Briganti, Alberto; Maurer, Tobias; Poel, H.G. Van Der; Oosterom, Matthias N. van; Leeuwen, Fijs W. B. van

doi:10.1002/aisy.202300192

Cited by 9 publications

(1 citation statement)

References 51 publications

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“…In patients, the biological complexity and heterogeneity of receptor expression in individual tumor lesions may result in relatively low signal intensities and subsequent low SBR for receptor-targeted imaging agents. This, of course, greatly influences and complicates surgical decision making [87]. This real-life finding seems to contradict with the promise offered by studies in preclinical, but highly artificial, models.…”

Section: Biological Clearance Routementioning

confidence: 99%

Lessons learned in application driven imaging agent design for image-guided surgery

Buckle,

Rietbergen,

de Wit -van der Veen

et al. 2024

Eur J Nucl Med Mol Imaging

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To meet the growing demand for intraoperative molecular imaging, the development of compatible imaging agents plays a crucial role. Given the unique requirements of surgical applications compared to diagnostics and therapy, maximizing translational potential necessitates distinctive imaging agent designs. For effective surgical guidance, exogenous signatures are essential and are achievable through a diverse range of imaging labels such as (radio)isotopes, fluorescent dyes, or combinations thereof. To achieve optimal in vivo utility a balanced molecular design of the tracer as a whole is required, which ensures a harmonious effect of the imaging label with the affinity and specificity (e.g., pharmacokinetics) of a pharmacophore/targeting moiety. This review outlines common design strategies and the effects of refinements in the molecular imaging agent design on the agent’s pharmacological profile. This includes the optimization of affinity, pharmacokinetics (including serum binding and target mediated background), biological clearance route, the achievable signal intensity, and the effect of dosing hereon.

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Section: Biological Clearance Routementioning

confidence: 99%

Lessons learned in application driven imaging agent design for image-guided surgery

Buckle,

Rietbergen,

de Wit -van der Veen

et al. 2024

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

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Delphi consensus project on prostate-specific membrane antigen (PSMA)–targeted surgery—outcomes from an international multidisciplinary panel

Berrens,

Scheltema,

Maurer

et al. 2023

Eur J Nucl Med Mol Imaging

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Steerable DROP-IN radioguidance during minimal-invasive non-robotic cervical and endometrial sentinel lymph node surgery

van Oosterom,

Diaz-Feijóo,

Santisteban

et al. 2024

Eur J Nucl Med Mol Imaging

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Purpose The recently introduced tethered DROP-IN gamma probe has revolutionized the way robotic radioguided surgery is performed, fully exploiting the nature of steerable robotic instruments. Given this success, the current first-in-human study investigates if the DROP-IN can also provide benefit in combination with steerable non-robotic instruments during conventional laparoscopic surgery, showing equivalence or even benefit over a traditional rigid gamma probe. Methods The evaluation was performed in ten patients during laparoscopic cervical (n = 4) and endometrial (n = 6) cancer sentinel lymph node (SLN) procedures. Surgical guidance was provided using the hybrid, or bi-modal, SLN tracer ICG-99mTc-nanocolloid. SLN detection was compared between the traditional rigid laparoscopic gamma probe, the combination of a DROP-IN gamma probe and a steerable laparoscopic instrument (LaproFlex), and fluorescence imaging. Results The gynecologists experienced an enlarged freedom of movement when using the DROP-IN + LaproFlex combination compared to the rigid laparoscopic probe, making it possible to better isolate the SLN signal from background signals. This did not translate into a change in the SLN find rate yet. In both cervical and endometrial cancer combined, the rigid probe and DROP-IN + LaproFlex combination provided an equivalent detection rate of 96%, while fluorescence provided 85%. Conclusion We have successfully demonstrated the in-human use of steerable DROP-IN radioguidance during laparoscopic cervical and endometrial cancer SLN procedures, expanding the utility beyond robotic procedures. Indicating an improved surgical experience, these findings encourage further investigation and consideration on a path towards routine clinical practice and improved patient outcome. Trial registration HCB/2021/0777 and NCT04492995; https://clinicaltrials.gov/study/NCT04492995

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Artificial Intelligence‐Supported Video Analysis as a Means to Assess the Impact of DROP‐IN Image Guidance on Robotic Surgeons: Radioguided Sentinel Lymph Node versus PSMA‐Targeted Prostate Cancer Surgery

Cited by 9 publications

References 51 publications

Lessons learned in application driven imaging agent design for image-guided surgery

Lessons learned in application driven imaging agent design for image-guided surgery

Delphi consensus project on prostate-specific membrane antigen (PSMA)–targeted surgery—outcomes from an international multidisciplinary panel

Steerable DROP-IN radioguidance during minimal-invasive non-robotic cervical and endometrial sentinel lymph node surgery

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