Articular cartilage with intra- and extrafibrillar waters: a chemo-mechanical model

Loret, Benjamin; Simões, Fernando M. F.

doi:10.1016/s0167-6636(03)00074-7

Cited by 37 publications

(39 citation statements)

References 30 publications

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“…Collagen represents 50-75% of the dry weight of AC while proteoglycans 15-30% [11,12]. There is around 80% water in the cartilage.…”

Section: What Do We Have To Mimic?mentioning

confidence: 99%

“…As can be seen in Figure 3 The compressive properties of cartilage are provided partly by the proteoglycans that resist compression because glycosaminoglycans chains repulse each other due to their negative charges [11]. These characteristics of proteoglycans, water attraction and repulsion from each other, provide the viscoelastic properties of articular cartilage, very important properties for effective lubrication.…”

Section: Collagen and Water Proteoglycansmentioning

confidence: 99%

See 1 more Smart Citation

Synovial joint lubrication — does nature teach more effective engineering lubrication strategies?

Neville

Morina

Liskiewicz

et al. 2007

Proceedings of the Institution of Mechanical Engineers, Part C:

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Nature shows numerous examples of systems which show energy efficiency, elegance in their design and optimum use of materials. Biomimetics is an emerging field of research in engineering and successes have been documented in the diverse fields of robotics, mechanics, materials engineering and many more. To date little biomimetics research has been directed towards tribology in terms of transferring technologies from biological systems into engineering applications. The potential for biomimicry has been recognised in terms of replicating natural lubricants but this system reviews the potential for mimicking the synovial joint as an efficient and durable tribological system for potential engineering systems. The use of materials and the integration of materials technology and fluid/surface interactions are central to the discussion.

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“…Collagen represents 50-75% of the dry weight of AC while proteoglycans 15-30% [11,12]. There is around 80% water in the cartilage.…”

Section: What Do We Have To Mimic?mentioning

confidence: 99%

Section: Collagen and Water Proteoglycansmentioning

confidence: 99%

Synovial joint lubrication — does nature teach more effective engineering lubrication strategies?

Neville

Morina

Liskiewicz

et al. 2007

Proceedings of the Institution of Mechanical Engineers, Part C:

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“…With these qualifications the model is thermodynamically admissible. Should ion migration processes be of interest to an investigator, then a more appropriate fully coupled theory should be employed (e.g., a fully coupled phenomenological theory or quadriphasic theory 29 ).…”

Section: Introductionmentioning

confidence: 99%

Time Evolution of Deformation in a Human Cartilage Under Cyclic Loading

et al. 2014

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-Recent imaging has revealed that in vivo contact deformations of human knee cartilage under physiological loadings are surprisingly large-typically on the order of 10%, but up to 20% or 30% of tibiofemora cartilage thickness depending on loading conditions. In this paper we develop a biphasic, large deformation, non-linear poroelastic model of cartilage that can accurately represent the time dependence and magnitude of cyclic cartilage deformations in vivo. The model takes into account cartilage tension-compression nonlinearity and a new constitutive relation in which the compressive stiffness and hydraulic permeability of the cartilage adjusts in response to the strain-dependent aggrecan concentration. The model predictions are validated using experimental test results on osteochondral plugs obtained from human cadavers. We find that model parameters can be optimised to give an excellent fit to the experimental data. Using typical hydraulic conductivity and stiffness parameters for healthy cartilage, we find that the experimentally observed transient and steady state tissue deformations under cyclic loading and unloading can be reproduced by the model. Steady state tissue deformations are shown to cycle between 10% (exudation strain) and 20% (total strain) in response to the cyclic test loads. At steadystate cyclic loading, the pore fluid exuded from the tissue is exactly equal to the pore fluid imbibed by the tissue during each load cycle.

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“…A small proportion of the water is contained in the intracellular space. Approximately 20-30% of the tissue water is contained in between collagen fibrils (interstitial water) and appears as a gel, while the remainder is stored in the pore space of the tissue [45][46][47]. Proteoglycans have a negative charge and the collagen fibres form a fibrous 3D meshwork that entraps the fluid-swollen proteoglycans.…”

Section: Articular Cartilage Structurementioning

confidence: 99%

“…Proteoglycans have a negative charge and the collagen fibres form a fibrous 3D meshwork that entraps the fluid-swollen proteoglycans. The fixed charge density (FCD) on proteoglycans attracts mobile counterions such as Na + [45]. The existence of proteoglycans in extrafibrillar space results in increasing concentration of mobile cations to keep electro-neutrality [48].…”

Section: Articular Cartilage Structurementioning

confidence: 99%

An Innovative Agent-Based Cellular Automata Framework for Simulating Articular Cartilage Biomechanics

Kashani¹

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Articular cartilage with intra- and extrafibrillar waters: a chemo-mechanical model

Cited by 37 publications

References 30 publications

Synovial joint lubrication — does nature teach more effective engineering lubrication strategies?

Synovial joint lubrication — does nature teach more effective engineering lubrication strategies?

Time Evolution of Deformation in a Human Cartilage Under Cyclic Loading

An Innovative Agent-Based Cellular Automata Framework for Simulating Articular Cartilage Biomechanics

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