Artichoke leaf extract for treating hypercholesterolaemia

Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Different pharmacological activities including hepatoprotective (Gebhardt & Fausel, 1997), antimicrobial (Zhu, Zhang, & Lo, 2004), antiatherogenic (Xia et al, 2014), antioxidant (Gebhardt & Fausel, 1997;Rezazadeh, Aliashrafi, et al, 2018), hypoglycemic (Fantini et al, 2011;Rondanelli et al, 2014), and anticancer (Nadova, Miadokova, Mucaji, Grancai, & Cipak, 2008) effects have been reported in previous studies for artichoke leaf extract (ALE). The hypolipidemic properties of ALE and its compounds have also been noticed (Bundy et al, 2008;Cicero et al, 2017;Englisch et al, 2000;Rondanelli et al, 2014;Wider, Pittler, Thompson-Coon, & Ernst, 2013). Artichoke can be useful also in statin-intolerant dyslipidemias (Banach et al, 2018).…”

Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Different pharmacological activities including hepatoprotective (Gebhardt & Fausel, 1997), antimicrobial (Zhu, Zhang, & Lo, 2004), antiatherogenic (Xia et al, 2014), antioxidant (Gebhardt & Fausel, 1997;Rezazadeh, Aliashrafi, et al, 2018), hypoglycemic (Fantini et al, 2011;Rondanelli et al, 2014), and anticancer (Nadova, Miadokova, Mucaji, Grancai, & Cipak, 2008) effects have been reported in previous studies for artichoke leaf extract (ALE). The hypolipidemic properties of ALE and its compounds have also been noticed (Bundy et al, 2008;Cicero et al, 2017;Englisch et al, 2000;Rondanelli et al, 2014;Wider, Pittler, Thompson-Coon, & Ernst, 2013). Artichoke can be useful also in statin-intolerant dyslipidemias (Banach et al, 2018).…”

Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial

“…A traditional use of artichoke leaf extracts is reported, in particular for its antioxidant [22], choleretic, hepatoprotective [16], and hypolipidemic effects [23]. Some clinical studies [24][25][26] as well as the Cochrane review [27] have demonstrated a decrease in blood lipid concentrations after consumption of artichoke leaf extracts. In preclinical investigations, the consumption of an artichoke leaf extract by C57BL/6 mice (500 mg/kg of bodyweight) or Wistar rats (200-400 mg/kg of bodyweight) was reported to limit weight gain, adipocyte hypertrophy, or high levels of circulating triglycerides and cholesterol within a high fat diet [28,29].…”

Occupational Contact Dermatitis Caused by Artichokes

“…Artichoke contains many substances of interest, including malic, citric, and succinic acids, as well as flavonoids (luteolin and apigenin). These substances potentially decrease lipemia and have a diuretic effect 6 , 7 , 23. The artichoke is also rich in potassium and magnesium 6.…”

“…These substances potentially decrease lipemia and have a diuretic effect. 6,7,23 The artichoke is also rich in potassium and magnesium. 6 These organic acids, such as phenolic acid, malic, citric, and succinic acids, can have an irritant effect.…”

Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Different pharmacological activities including hepatoprotective (Gebhardt & Fausel, 1997), antimicrobial (Zhu, Zhang, & Lo, 2004), antiatherogenic (Xia et al, 2014), antioxidant (Gebhardt & Fausel, 1997;Rezazadeh, Aliashrafi, et al, 2018), hypoglycemic (Fantini et al, 2011;Rondanelli et al, 2014), and anticancer (Nadova, Miadokova, Mucaji, Grancai, & Cipak, 2008) effects have been reported in previous studies for artichoke leaf extract (ALE). The hypolipidemic properties of ALE and its compounds have also been noticed (Bundy et al, 2008;Cicero et al, 2017;Englisch et al, 2000;Rondanelli et al, 2014;Wider, Pittler, Thompson-Coon, & Ernst, 2013). Artichoke can be useful also in statin-intolerant dyslipidemias (Banach et al, 2018).…”

Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial

“…A traditional use of artichoke leaf extracts is reported, in particular for its antioxidant [22], choleretic, hepatoprotective [16], and hypolipidemic effects [23]. Some clinical studies [24][25][26] as well as the Cochrane review [27] have demonstrated a decrease in blood lipid concentrations after consumption of artichoke leaf extracts. In preclinical investigations, the consumption of an artichoke leaf extract by C57BL/6 mice (500 mg/kg of bodyweight) or Wistar rats (200-400 mg/kg of bodyweight) was reported to limit weight gain, adipocyte hypertrophy, or high levels of circulating triglycerides and cholesterol within a high fat diet [28,29].…”

Occupational Contact Dermatitis Caused by Artichokes

“…Artichoke contains many substances of interest, including malic, citric, and succinic acids, as well as flavonoids (luteolin and apigenin). These substances potentially decrease lipemia and have a diuretic effect 6 , 7 , 23. The artichoke is also rich in potassium and magnesium 6.…”

“…These substances potentially decrease lipemia and have a diuretic effect. 6,7,23 The artichoke is also rich in potassium and magnesium. 6 These organic acids, such as phenolic acid, malic, citric, and succinic acids, can have an irritant effect.…”

Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…Different pharmacological activities including hepatoprotective (Gebhardt & Fausel, 1997), antimicrobial (Zhu, Zhang, & Lo, 2004), antiatherogenic (Xia et al, 2014), antioxidant (Gebhardt & Fausel, 1997;Rezazadeh, Aliashrafi, et al, 2018), hypoglycemic (Fantini et al, 2011;Rondanelli et al, 2014), and anticancer (Nadova, Miadokova, Mucaji, Grancai, & Cipak, 2008) effects have been reported in previous studies for artichoke leaf extract (ALE). The hypolipidemic properties of ALE and its compounds have also been noticed (Bundy et al, 2008;Cicero et al, 2017;Englisch et al, 2000;Rondanelli et al, 2014;Wider, Pittler, Thompson-Coon, & Ernst, 2013). Artichoke can be useful also in statin-intolerant dyslipidemias (Banach et al, 2018).…”

Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial

“…A traditional use of artichoke leaf extracts is reported, in particular for its antioxidant [22], choleretic, hepatoprotective [16], and hypolipidemic effects [23]. Some clinical studies [24][25][26] as well as the Cochrane review [27] have demonstrated a decrease in blood lipid concentrations after consumption of artichoke leaf extracts. In preclinical investigations, the consumption of an artichoke leaf extract by C57BL/6 mice (500 mg/kg of bodyweight) or Wistar rats (200-400 mg/kg of bodyweight) was reported to limit weight gain, adipocyte hypertrophy, or high levels of circulating triglycerides and cholesterol within a high fat diet [28,29].…”

Occupational Contact Dermatitis Caused by Artichokes

“…Artichoke contains many substances of interest, including malic, citric, and succinic acids, as well as flavonoids (luteolin and apigenin). These substances potentially decrease lipemia and have a diuretic effect 6 , 7 , 23. The artichoke is also rich in potassium and magnesium 6.…”

“…These substances potentially decrease lipemia and have a diuretic effect. 6,7,23 The artichoke is also rich in potassium and magnesium. 6 These organic acids, such as phenolic acid, malic, citric, and succinic acids, can have an irritant effect.…”