Artesunate reduces cell growth and induces ferroptosis in therapy-resistant renal cell carcinoma cells

Juengel, Eva; Markowitsch, Sascha D.; Schupp, Patricia; Schunke, Jenny; Efferth, Thomas; Mager, René; Haferkamp, Axel

doi:10.1016/s1569-9056(19)33294-4

Cited by 1 publication

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“…Apart from the endoperoxide moiety, the heme that cancer cells produce plays an important role in activating ART, producing abundant free radicals that damage cancer cells [ 16 ]. The anticancer effects of ART work through affecting various processes and pathways in cancer cells, such as arresting the cell cycle [ 14 ], inhibiting angiogenesis [ 64 ] and ferroptosis [ 65 ], inducing apoptosis [ 14 ], inhibiting proliferation [ 66 ], and inducing autophagy [ 67 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

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Recent Advances in the Therapeutic Efficacy of Artesunate

2022

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Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

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Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

“…Ferroptosis was found to be responsible for the inhibition of these therapy-resistant RCC cells. ART treatment caused cell cycle arrest in the G 0 G 1 phase and changes in the expression of proteins of the Akt/mTOR signalling pathway [ 66 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%