Arterial Stiffness Parameters Correlate with Estimated Cardiovascular Risk in Humans: A Clinical Study

Tąpolska, Małgorzata; Spałek, Maciej; Szybowicz, Urszula; Domin, Remigiusz; Owsik, Karolina; Sochacka, Katarzyna; Skrypnik, Damian; Bogdański, Paweł; Owecki, Maciej

doi:10.3390/ijerph16142547

Cited by 19 publications

(14 citation statements)

References 44 publications

(47 reference statements)

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“…ird, in the study, we did not evaluate arterial stiffness parameters, which were treated as a novel predictor of cardiovascular risk in humans [35]. Finally, it should be noted that our data merely represent a small clinical practice, and clinical recommendations cannot be made based on the results.…”

Section: Discussionmentioning

confidence: 93%

Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity

Zhao

Zhang

et al. 2020

BioMed Research International

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It has been recognized that people with obesity are more likely to have low growth hormone secretion. Recent studies have also confirmed that the abnormalities of the growth hormone/insulin-like growth factor 1 axis were associated with cardiovascular complications in people with obesity. However, little is known about whether recombinant human growth hormone therapy could improve cardiovascular and metabolic risks in obese children. This study aims to evaluate the effect of one-year growth hormone therapy on obesity-related comorbidities and to assess the safety in Chinese boys with obesity. Eighteen boys with obesity were treated with recombinant human growth hormone for one year. Anthropometric measurements, endocrine testing, and cardiovascular risk markers were performed in all obese boys in baseline, and follow-up visits were performed at 3 months, 6 months, 9 months, and one year, respectively. After one year of recombinant human growth hormone treatment, the body mass index standard deviation scores decreased (P<0.001) and insulin-like growth factor 1 levels increased (P<0.001). GH treatment also reduced low density lipoprotein cholesterol (P<0.001), total cholesterol (P<0.001), triglycerides (P=0.042), and alanine aminotransferase (P=0.027) when compared with the baseline. One-year of recombinant human growth hormone treatment could improve cardiometabolic risk markers, without adverse effects on glucose homeostasis in boys with obesity.

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Section: Discussionmentioning

confidence: 93%

Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity

Zhao

Zhang

et al. 2020

BioMed Research International

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“…The coexistence of diabetes and hypertension was summarized [48]. Arterial stiffness indices (stiffness index and reflection index) were found to be a strong predictor of future CVD events [49]. In addition, in mothers with gestational diabetes mellitus and dyslipidemia, their child had a higher rate of obesity [50].…”

Section: Discussionmentioning

confidence: 99%

Associated Factors of Hypertension in Women and Men in Vietnam: A Cross-Sectional Study

Cường

Bao

Tuấn

et al. 2019

IJERPH

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Background: Hypertension is a direct cardiovascular disease risk. It causes a heavy burden on the healthcare system globally. We aim to assess hypertension occurrence and its associated factors among women and men in Vietnam. Methods: A cross-sectional study was conducted from January to February 2019 on 2203 community-dwelling women and men aged 18 years or above. Participants’ characteristics, comorbidity, behaviors, and physical measures were evaluated. Hypertension was classified as systolic/diastolic blood pressure ≥140/90 mmHg or using antihypertensive medication. We analyzed data using logistic regression models. Results: The prevalence of hypertension was 24.3% (20.9% in women, 29.1% in men). For women, older age (odds ratio, OR, 6.80–12.41; p < 0.001), income above the poverty line (OR, 0.64; p = 0.008), diabetes comorbid (OR, 2.98; p < 0.001), added salts consumption (OR, 1.80; p < 0.001), overweight/obesity (OR, 1.64; p = 0.005), abdominal obesity (OR, 2.07; p < 0.001) were associated with hypertension. For men, older age (OR, 2.67–5.92; p < 0.001), diabetes comorbid (OR, 2.25; p = 0.010), smoking (OR, 1.38; p = 0.046), and overweight/obesity (OR, 2.18; p < 0.001) were associated with hypertension. Conclusions: Hypertension is prevalent in Vietnamese people. The associated factors of hypertension are varied by gender.

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“…Arterial stiffness is said to be a novel predictor of cardiovascular events (34). A study by Topolska et al (2019) investigated the correlation between arterial stiffness parameters and estimated cardiovascular disease risk (RISK) in a cohort of Polish patients divided by age, sex, and BMI.…”

Section: Discussionmentioning

confidence: 99%

Obesity, elevated levels of fasting plasma glucose and type 2 diabetes are associated with aortic stiffness

KUPCOVA¹,

MURIN²,

WIMMEROVA³

et al. 2023

BLL

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OBJECTIVES: Obesity and metabolic syndrome (MetS) are associated with structural and functional vascular abnormalities. MetS and its components may increase arterial stiffness and the risk of cardiovascular events. However, the relationship of MetS and its components, including obesity, with arterial stiffness is still not fully understood. SUBJECTS AND METHODS: In a group of 116 patients undergoing treatment for hypertension, we searched for the relationships between parameters of MetS and aortic stiffness expressed by pulse wave velocity (PWVAo). PWVAo was measured using an arteriograph working on the oscillometric principle, and pulse wave analysis (PWA) for noninvasive assessment of the parameters of central hemodynamics. RESULTS: From the cluster of parameters of MetS we found a signifi cant association between body mass index (BMI) and aortic stiffness, and between fasting plasma glucose/type 2 diabetes (FPG/T2DM) and aortic stiffness. We did not fi nd signifi cant relationships between other components of MetS (HDL cholesterol and triglycerides) and aortic stiffness, based on the infl uence of hypolipidemic therapy. Arterial stiffness increased with age and was higher in females. CONCLUSION: Arterial stiffness was associated with age, sex, and MetS components (BMI and FPG/T2DM). Surprisingly, the parameters of dyslipidemia do not infl uence stiffness parameters, which can be explained by hypolipidemic therapy. The infl uence of hypolipidemic therapy should therefore be borne in mind when evaluating arterial tree function (Tab. 7, Ref. 62).

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Arterial Stiffness Parameters Correlate with Estimated Cardiovascular Risk in Humans: A Clinical Study

Cited by 19 publications

References 44 publications

Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity

Effect of One-Year Growth Hormone Therapy on Cardiometabolic Risk Factors in Boys with Obesity

Associated Factors of Hypertension in Women and Men in Vietnam: A Cross-Sectional Study

Obesity, elevated levels of fasting plasma glucose and type 2 diabetes are associated with aortic stiffness

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