Arterial stiffness/central hemodynamics, renal function, and development of hypertension over the short term

Tomiyama, Hirofumi; Townsend, Raymond R.; Matsumoto, Chisa; Kimura, Kana; Odaira, Mari; Yoshida, Masanobu; Shiina, Kazuki; Yamashina, Akira

doi:10.1097/hjh.0b013e3283658e7d

Cited by 18 publications

(18 citation statements)

References 40 publications

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“…A plausible mechanism is that increased arterial stiffness increases the amplitude of the forward pressure wave originating from the left ventricle. Wave reflection has also been reported as a risk factor for the development of hypertension 3, 5, 16. In addition to arterial stiffness, which increases the speed of propagation of the pressure wave originating from the left ventricle along the arterial wall, peripheral wave reflectance also affects the wave reflection; thus, arterial stiffness and wave reflection may reflect partially different facets of damage in the arterial tree 7, 8, 9.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, most clinical studies carried out to examine the association of vascular abnormalities with blood pressure elevation have been prospective 2‐point assessment studies3, 5, 16; therefore, the effects of time‐varying explanatory variables/covariates during the study period on the outcome variable have not been evaluated precisely 10. Accordingly, we considered that GEE analysis and/or MML analysis of repeated‐measures data obtained over a longitudinal time course would be more appropriate to verify the association of arterial stiffness and wave reflection with the risk of development of hypertension 10.…”

Section: Discussionmentioning

confidence: 99%

“…Because it is also a major risk factor for the development of cardiovascular disease,1 preventing the development of hypertension is of major medical and societal importance 1, 2. Based on the results of several prospective studies, arterial stiffness (ie, macrovascular damage) is recognized to be a key player in the development of hypertension 3, 4, 5. Alternatively, microvascular damage in the arterial tree has also been proposed as an important factor for the development of hypertension 6, 7.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Tomiyama

Komatsu

Shiina

et al. 2018

JAHA

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BackgroundWe conducted analyses of repeated‐measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis of hypertension.Methods and ResultsIn 3172 middle‐aged (42±9 years) healthy Japanese men without hypertension at the study baseline, systolic and diastolic blood pressures, brachial–ankle pulse wave velocity, and radial augmentation index were measured annually during a 9‐year study period. Of these, 474 participants (15%) developed hypertension by the end of the study period. Binary logistic regression analysis demonstrated significant individual odds ratios for both baseline brachial–ankle pulse wave velocity and radial augmentation index for the development of hypertension. The rate of onset of hypertension during the study period was highest in the participant group with high values for both brachial–ankle pulse wave velocity and radial augmentation index at study baseline (262 of 965 participants: 27%). The generalized estimating equation analysis revealed that both radial augmentation index (estimate=0.06, SE=0.03, P=0.05) and brachial–ankle pulse wave velocity (estimate=0.07×10−1, SE=0.02×10−1, P<0.01) showed significant longitudinal association with new onset of hypertension, with no significant interaction.ConclusionsIn Japanese men, abnormal wave reflection and increased arterial stiffness may be additively associated with the risk of new onset of hypertension. Abnormal wave reflection and elevated central blood pressure may be longitudinally associated with increase in arterial stiffness, and this longitudinal association may be a mechanism underlying the additive effect of these 2 variables on the risk of new onset of hypertension.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Tomiyama

Komatsu

Shiina

et al. 2018

JAHA

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“…Generally, reduced eGFR is associated with greater arterial stiffness [15 ▪ ], but some studies were not able to show an independent contribution of decreased eGFR to increased PWV [16,17]. In the CRIC study, we observed that each 10 ml/min/1.73 m 2 decline in eGFR was associated independently with a 0.23 m/s increase in PWV, as shown in Fig.…”

Section: Introductionmentioning

confidence: 71%

Arterial stiffness and chronic kidney disease

Townsend

2015

Current Opinion in Nephrology and Hypertension

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Purpose of review The purpose of this review is to highlight what the Chronic Renal Insufficiency Cohort (CRIC) study has taught us regarding arterial stiffness in chronic kidney disease. The CRIC study began in mid-2003 and enrolled more than 3900 people with chronic kidney disease. Recent findings The recent findings from the CRIC study are covered in 10 lessons. Within the CRIC study, we enrolled about 2800 participants who underwent a pulse wave velocity measurement. At the time of initial funding, very little was known about the role of arterial stiffness in chronic, nondialyzed, kidney disease. The lessons span the gamut from simple correlations to measures such as central arterial pressure profiles and reproducibility of pulse wave velocity measurements between operators, to relationships of pulse wave velocity to kidney function, protein excretion, cardiovascular disease prevalence, and incident cardiovascular events such as heart failure. Summary The implications from these lessons are that pulse wave velocity is a robust, reproducible measure of arterial stiffness which adds important information to standard clinical assessments such as SBP and DBP in a population with chronic kidney disease, a disorder with high likelihood of progressive kidney function loss, and a substantial predisposition to cardiovascular disease.

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“…These phenomena cause the condition referred to as pulsatile nephropathy that results in accelerated renal function decline [5,12,16,45]. Based on these logical backgrounds, several prospective studies have been conducted to examine whether increased arterial stiffness might be a risk factor for accelerated renal function decline [35,46,47,48,49,50,51,52,53]. The results of these studies are summarized in table 1.…”

Section: Vascular Damage and Renal Dysfunctionmentioning

confidence: 99%

Clinical Considerations for the Association between Vascular Damage and Chronic Kidney Disease

Tomiyama

Yamashina²

2014

Pulse

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Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. Recently, noninvasive and simple morphological and functional methods have been introduced to assess atherosclerotic vascular damage. This review describes the association of CKD with vascular damage as assessed by these methods. Carotid intima-media thickness (IMT) and coronary artery calcium score (CACS) are morphological parameters of vascular damage, and an ankle-brachial index (ABI) <0.90 suggests the presence of peripheral arterial disease (i.e., it represents advanced atherosclerosis). Several prospective studies have demonstrated that CKD is a risk factor for an increased IMT, an increased CACS and a decreased ABI. While it has not been clarified whether measuring the IMT or CACS might be useful to predict the progression of renal function decline, a reduced ABI has been demonstrated as a predictor of accelerated renal function decline. On the other hand, pulse wave velocity (PWV) is a marker of arterial stiffness rather than atherosclerosis, reflecting functional abnormalities caused by vascular damage, and moderate-to-severe CKD may be a risk factor for the progression of arterial stiffness. The measurement of functional markers, especially of PWV or pulse pressure, has been demonstrated to be useful to predict the rate of progression of renal function decline. Thus, renal dysfunction and atherogenic states may be components of a vicious cycle, and vascular function abnormalities associated with atherosclerosis may accelerate this cycle. As the next step, we propose to examine whether improvement of vascular function abnormalities can interrupt this vicious cycle.

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Arterial stiffness/central hemodynamics, renal function, and development of hypertension over the short term

Abstract: The mechanisms underlying the association between arterial stiffness/central hemodynamics and the short-term development of hypertension appear to differ from those underlying the association between kidney function and the short-term development of hypertension.

Cited by 18 publications

References 40 publications

Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

Arterial stiffness and chronic kidney disease

Clinical Considerations for the Association between Vascular Damage and Chronic Kidney Disease

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