Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome

Abstract

a b s t r a c tWe conducted a study to evaluate arterial stiffness markers in subjects with acute ischemic stroke and metabolic syndrome and in relation to TOAST subtype of stroke. We enrolled 130 patients with acute ischemic stroke and metabolic syndrome, 127 patients with acute ischemic stroke without metabolic syndrome and 120 control subjects without acute stroke. Applanation tonometry to record pulse wave velocity (PWV). Stroke patients with metabolic syndrome, compared control subjects without stroke showed higher PWV. In subjects with ischemic stroke and metabolic syndrome, PWV was more significantly and positively correlated with body mass index, systolic blood pressure, hypertension, diabetes, glucose blood levels, LDL cholesterol levels, total cholesterol levels, micro-albuminuria, carotid plaque, previous brain infarct at neuro-imaging. Our findings underline important role of both small vessel disease and atherosclerosis on arterial stiffness pathogenesis in the clinical setting of metabolic syndrome.

Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes

“…Thus inflammation marker evaluation has in DFS multiple points of potential importance concerning a better evaluation and analysis of these crucial key points: (1) pathogenetic role in ulcers and their micro and macrovascular background; (2)possible link between inflammation state and adipo-metabolic axis; (3) predictive role towards foot complications such as ulcers incidence; (4) putative role as markers of gravity of wounds and ulcers in a diabetic foot; (5) association with cardiovascular co-morbidity (prevalent and incident) in subjects with DFS; (6) prognostic role towards ulcer healing; (7) strict association with peripheral artery comorbidity (PAD); and (8) pathogentic links with metabolic syndrome and NASH [93][94][95][96][97][98][99] . It explains that a strict and prospective inflammation marker evaluation could be useful in practical management of foot complications in diabetic subjects in every medical setting (Internal Medicine, Diabetology, Surgery, Orthopedics) to better evaluate a complex disease such as DFS in a multispecialistic management contest.…”

Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

“…PWV was calculated as the distance travelled by the arterial pulse wave (meters) divided by the time delay between the two arterial points (seconds), thus expressed as meters per second (m/s). The "distance between the two arterial points" was measured using the total distance between the carotid and femoral sites of measurement [34,35].…”

Hormones and Arterial Stiffness in Patients with Chronic Kidney Disease

“…AS has been associated with numerous comorbidities and, most importantly, shown to independently predict all-cause and cardiovascular mortality, fatal and nonfatal coronary events and fatal strokes, both in the general and CKD populations [12][13][14][15][16] . Increased left ventricular stress and reduced coronary perfusion, both caused by AS, lead to cardiac hypertrophy and myopathy, thus resulting in congestive heart failure and sudden death in CKD patients.…”