Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis

Aulie, Hanne Aaserud; Selvaag, Anne M; Günther, Anne; Lilleby, Vibke; Molberg, Øyvind; Hartmann, Anders; Holdaas, Hallvard; Flatø, Berit

doi:10.1136/annrheumdis-2013-204804

Cited by 26 publications

(25 citation statements)

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“…The strength of the study is the long-term follow-up over 29 years of this cohort that has been described in several publications [17–19, 46, 48]. There are however some limitations of the study.…”

Section: Discussionmentioning

confidence: 99%

Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

et al. 2017

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BackgroundThere are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damage in patients with long-term active JIA.MethodsPatients diagnosed from 1980 to 1985, who had active disease at 15-, 23- or 29-year follow-up and arthritis in the wrists during the disease course, were reexamined with radiographs of hands/wrists. We used the adapted version of the Sharp van der Heijde (aSvdH) score and Carpal Height Ratio (CHR) to evaluate radiographic outcome.ResultsSixty patients, mean age 38 years, were reexamined at median 29-year follow-up. 33 patients (55%) had an aSvdH score >0, median score was 4.0 (range 0–313), and 25% of the scores were high (≥53). Most patients with radiographic damage (88%) had both erosions and JSN. 52% of the patients had damage in the wrists, 43% in the MCP joints and 40% in the PIP joints.The CHR correlated strongly with the aSvdH. Both scores had high correlations with the Juvenile Arthritis Damage Index and the number of joints with limited range of motion (LROM) (rs = -0.688 to 0.743, p ≤ 0.001). The aSvdH correlated weakly with measures of disease activity.The number of joints with LROM, ESR and the HAQ disability score at 15 years and HLAB27 positivity predicted the aSvdH score and the CHR at 29-year follow-up.ConclusionsThe majority of patients with long-term active JIA had modest radiographic damage, but more frequently in wrists than in fingers. The radiographic scores correlated well with measures of disease damage. Restricted mobility in joints at 15 years was the most important predictor of radiographic damage at 29 years.

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Section: Discussionmentioning

confidence: 99%

Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

et al. 2017

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“…The three primary non-invasive techniques utilized are flow-mediated dilation, carotid intima-media thickness, and pulse wave velocity. These modalities are vascular measures of early atherosclerosis and several investigators have demonstrated these markers to be abnormal or significantly different in patients with JIA in comparison to control groups[17-21]. Coulson et al completed a recent review summarizing the literature available on this subject and concluded that while surrogate markers in JIA patients suggest cardiovascular abnormalities, there is an unclear relationship between long-term cardiovascular risk and JIA and further studies are necessary[12].…”

Section: Discussionmentioning

confidence: 99%

“…The participant group was comprised of a previously described cohort of 373 patients who were first referred to OUH from 1980 through 1985 and diagnosed with JRA[4, 15, 16]. Patients evaluated after a median of 29 years disease duration (170/373, 46%) were included in the study[6, 17]. Evaluation at 29 years consisted of one of the following: a mailed questionnaire about cardiovascular comorbidity/risk factors if the patient did not have active disease at prior 15 and 23 year follow-up (86/170; 51%), or an extended clinical exam with interview if the patient did have active disease at 15 and/or 23 year follow-up (84/170; 49%).…”

Section: Methodsmentioning

confidence: 99%

Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study

Anderson

Aulie

et al. 2016

Scandinavian Journal of Rheumatology

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Objective Evaluate the frequency of cardiovascular disease (CVD) and CVD risk factor development in adult patients previously diagnosed with juvenile idiopathic arthritis (JIA). Methods A cohort study was conducted utilizing patients at two academic institutions (Cohorts 1 and 2). Each institution evaluated the common endpoint of CVD outcomes and CVD risk factor development in adults age ≥30 years and at 29 year follow-up from disease onset in cohorts 1 and 2, respectively, with comparison to control groups of similar age and sex. Results Cohort 1 included 41 patients with JIA and follow-up ≥30 years of age with comparison to 41 controls. Three patients (7%) had CVD, compared to 1 control (2%; p = 0.31). Cohort 2 included 170 patients with JIA and median of 29 year follow-up from disease onset with comparison to 91 controls. Two patients (2%) had CVD, compared to 0 controls (p = 0.29). The presence of CVD risk factors were found to be increased in the JIA group compared to controls in three categories: family history of CVD (cohort 1), hypertension (cohort 2), and ever smokers (cohorts 2). Conclusions There is no increase in CVD events in patients with JIA 29 years following disease onset when compared to the general population. As these cohorts age, it will be informative to evaluate if this baseline risk remains present or a trend toward increasing CVD emerges. Continued longitudinal follow-up of these cohorts and larger population-based studies are needed to establish a definitive relationship between JIA and CVD.

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“…При про-спективном исследовании (средняя продолжительность 29 лет) пациентов с ЮИА, имевших признаки продол-жающейся активности заболевания, выявлено сохране-ние увеличенной артериальной жесткости, оцениваемой по скорости распространения пульсовой волны (pulse wave velocity, РWV), и связанное с этим повышение уровня диастолического артериального давления. Повышенная жесткость артерий и осложнения, связанные с ней (гипер-трофия левого желудочка, инсульт и инфаркт миокарда), наблюдаются в зрелом возрасте, тогда как истоки при-ходятся на детский/подростковый возрасты и характери-зуются доклинической и бессимптомной фазой, которая длится несколько десятилетий [93].…”

Section: эндотелиальная дисфункция при ювенильном идиопатическом артритеunclassified

Rheumatic Diseases and Endothelial Function

Марчук¹,

Соботюк²,

Бочанцев³

2018

Vopr. sovr. pediatr.

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Arterial haemodynamics and coronary artery calcification in adult patients with juvenile idiopathic arthritis

Abstract: JIA patients with long-term active disease had altered arterial haemodynamics compared with controls in our study. PWV was mainly determined by increased DBP, a parameter that again was associated with JIA disease and treatment variables.

Cited by 26 publications

References 43 publications

Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

Radiographic damage in hands and wrists of patients with juvenile idiopathic arthritis after 29 years of disease duration

Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study

Rheumatic Diseases and Endothelial Function

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