Arterial function after successful renal transplantation

Zoungas, Sophia; Kerr, Peter G.; Chadban, Steven J.; Muske, Christine; Ristevski, Sonya; Atkins, Robert C.; McNeil, John J; McGrath, Barry P

doi:10.1111/j.1523-1755.2004.00595.x

Cited by 99 publications

(105 citation statements)

References 23 publications

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“…Arterial calcification and stiffness are known to be associated in CKD (34), and lower T 50 has been associated with progression in arterial stiffness (22). The discrepancy in results in our study may be due to the fact that APWV is a composite of functional and structural components (29,35). Although we adjusted for mean arterial pressure, our shortterm study could have missed a structural association due to functional noise, which has been reported to be of a magnitude of up to 1.3 m/s (35).…”

Section: Discussioncontrasting

confidence: 55%

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Dahle

Åsberg

Hartmann

et al. 2016

American Journal of Transplantation

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Section: Discussioncontrasting

confidence: 55%

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Dahle

Åsberg

Hartmann

et al. 2016

American Journal of Transplantation

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“…Also an improvement in central arterial stiffness was observed after a year of follow-up [69,70]. This is in line with the other evidence that cardiac function in DM transplant candidates is carefully evaluated prior to transplantation and LV systolic, diastolic function and arterial compliance improves shortly after a successful renal transplant [71][72][73][74][75]. It was also concluded that assessment of arterial stiffness may improve pre-transplantation risk assessment both in donors and recipients [70].…”

Section: Risk In Kidney Transplanted Patientssupporting

confidence: 68%

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Khoshdel¹

2012

Cardiovascular Risk Factors

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“…Several but not all studies have suggested that PWV may fall after KT15, 16 which may represent a global improvement in vascular health translating into improvement in graft and patient survival 11, 17, 18. However, longitudinal data relating to large‐vessel vascular remodeling in a transplant population are lacking, especially concerning specific changes in vessel diameter, thickness and wall stress.…”

Section: Introductionmentioning

confidence: 99%

Reversal of Arterial Stiffness and Maladaptative Arterial Remodeling After Kidney Transplantation

Karras

Boutouyrie

Briet

et al. 2017

JAHA

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BackgroundChronic kidney disease is characterized by stiffening, thinning, dilatation, and increased circumferential wall stress of large arteries, associated with increased cardiovascular risk. Kidney transplantation (KT) reverses many pathological features of chronic kidney disease and improves life expectancy; however, longitudinal studies exploring the impact of KT on recipient large arteries are scarce.Methods and ResultsThis study was designed to appraise arterial changes following KT. Carotid‐femoral pulse wave velocity, carotid remodeling (circumferential wall stress and carotid internal diameter), and stiffness were measured in 161 consecutive recipients receiving either a living (n=49) or a deceased (n=112) donor allograft, at 3 and 12 months after transplantation. Mean pulse wave velocity decreased from 10.8 m/s (95% confidence interval, 10.5–11.2 m/s) (at month 3) to 10.1 m/s (95% confidence interval, 9.8–10.5 m/s) (at month 12) (P<0.001). After multivariate adjustment, pulse wave velocity reduction from month 3 to month 12 was significantly larger in the living donor allograft KT (P<0.001). Circumferential wall stress decreased, 70 kPa (95% confidence interval, 68–72 kPa) to 64 kPa (95% confidence interval, 62–67 kPa), as well as carotid internal diameter and carotid stiffness (P<0.001 for all). Reductions in circumferential wall stress, diameter, and stiffness were significantly larger in the living donor allograft KT (P<0.001). When deceased donor allograft patients were classified into standard and expanded criteria donors, changes in both pulse wave velocity and circumferential wall stress were blunted in expanded criteria donors. Changes were independent of graft function and blood pressure changes.ConclusionsLarge‐artery stiffness and maladaptive carotid artery remodeling of chronic kidney disease is partially reversed within 12 months of KT and appears unrelated to renal function. Improvements were independently associated with live organ donation. Our data suggest that expanded criteria donors may hamper vascular recovery.

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Arterial function after successful renal transplantation

Abstract: One year after successful renal transplantation, improvement in cardiovascular risk factors was associated with improvement in indices of arterial stiffness.

Cited by 99 publications

References 23 publications

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Serum Calcification Propensity Is a Strong and Independent Determinant of Cardiac and All-Cause Mortality in Kidney Transplant Recipients

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Reversal of Arterial Stiffness and Maladaptative Arterial Remodeling After Kidney Transplantation

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