Art. I.???On Irritable Heart; a Clinical Study of a Form of Functional Cardiac Disorder and its Consequences

Costa, José Jackson do Nascimento

doi:10.1097/00000441-187101000-00001

Cited by 183 publications

(103 citation statements)

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“…In addition, our global transcriptome analyses on the entire heart tissue cannot exclude the possibility that there is small and local tissue damage in the long exposure group. Although an active tissue repair process was observed in our PTSD animal model, the likelihood of permanent and irreversible heart damage resulting from the exposure of a long-term constant or repeated stressful condition (such as soldiers with 1-3 y of combat duty in the US Civil War) could not be excluded (16). Nevertheless, the mouse model used in this study provides a good model to study the short-term physiological changes resulting from traumatic event exposure.…”

Section: Discussionmentioning

confidence: 98%

“…The association between PTSD and heart disorders is welldocumented (12-15); however, some of these associations have been attributed to anxiety disorder-associated symptoms instead of heart tissue damage, such as found in Da Costa syndrome (soldier's heart) (16). The mouse model used in these studies clearly displays some of the behavior and psychological characteristics of PTSD in human patients.…”

Section: Discussionmentioning

confidence: 99%

“…However, the initial heart injury followed by a quick tissue repair process may have long-term functional implications on the heart and provide some molecular bases for conditions, such as Da Costa syndrome. Indeed, the study by Da Costa (16) showed long-term and irreversible changes in the hearts of soldiers exposed to the stressful conditions of the US Civil War over periods of 1-3 y. Perhaps really long-term stress exposures lead directly to irreversible changes in the heart, which is reflected by heart pain, cardiac arrhythmias, and heart failure.…”

Section: Discussionmentioning

confidence: 99%

“…An 1871 report noted that serious cardiac disorders (cardiomyopathies, heart failure, heart pain, etc.) were a consequence of extended stress exposures in soldiers from the US Civil War (16). This report led to our interest in examining the effects of short-term stress exposure on heart tissues in the PTSD mouse model.…”

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confidence: 99%

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Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder

Cho

Lee

Hammamieh

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Posttraumatic stress disorder (PTSD) is a common condition induced by life-threatening stress, such as that experienced by soldiers under battlefield conditions. Other than the commonly recognized behavioral and psychological dysfunction, epidemiological studies have also revealed that PTSD patients have a higher risk of other diseases, such as cardiovascular disorders. Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation. Our results revealed acute heart injury associated with the traumatic experience, reflecting the underlying biological injury processes of the immune response, extracellular matrix remodeling, epithelial-to-mesenchymal cell transitions, and cell proliferation. Whether this type of injury has any longterm effects on heart function is yet to be determined. The differing responses to stress leading to acute heart injury in different inbred strains of mice also suggest that this response has a genetic as well as an environmental component. Accordingly, the results from this study suggest a molecular basis for the observed higher risk of cardiovascular disorders in PTSD patients, which raises the likelihood of cardiac dysfunction induced by long-term stress exposures.systems biology | transcriptome | microRNA

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder

Cho

Lee

Hammamieh

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…Several labels have been used to classify these patients, the most frequently used being Da Costa syndrome [1], neurocirculatory asthenia [2], anxiety neurosis [3], functional cardiovascular disease [4], cardiac neurosis [5], or hyperventilation syndrome (HVS) [6]. The breathing pattern of these patients is often irregular.…”

mentioning

confidence: 99%

Unsteadiness of breathing in patients with hyperventilation syndrome and anxiety disorders

Han

Stegen²,

Simkens³

et al. 1997

Eur Respir J

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Simply breathing via a mouthpiece and pneumotachograph made end-tidal CO 2 fractional concentration (FET,CO 2 ) decrease progressively both in hyperventilators and in patients with anxiety disorders, but not in normals. At the start of the measurement the FET,CO 2 was not different between patients and healthy subjects. In patients ≤28 yrs, the decrease of FET,CO 2 resulted from a higher tidal volume, and in patients ≥29 years from an increase in frequency. After voluntary hyperventilation, the recovery of FET,CO 2 was delayed in patients, due to a slower normalization of respiratory frequency in females and in older males, and of tidal volume in younger males, and also due to less frequent end-expiratory pauses. When breathing was recorded first by means of inductive plethysmography (Respitrace), the progressive decline of FET,CO 2 seen in patients was not observed: from the onset of the recording, FET,CO 2 was reduced in patients. It did not change further when, immediately afterwards, the subject switched to mouthpiece breathing.The finding that breathing through a mouthpiece induces hyperventilation in patients and that recovery of FET,CO 2 is delayed after voluntary hyperventilation, suggests that the respiratory control system is less resistant to challenges (mouthpiece or voluntary hyperventilation) in those patients. On the other hand, the lower values of FET,CO 2 measured during recording by means of a Respitrace probably result from a challenge, prior to the recordings, induced by the fitting of the measuring device to the patient. This unsteadiness of breathing characterizes patients with hyperventilation syndrome and those with anxiety disorders, but is not sufficiently sensitive to be used for individual diagnosis.

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Neurocirculatory Asthenia, Anxiety Neurosis or the Effort Syndrome

Cohen¹,

White²,

Johnson³

1948

Arch Intern Med

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Art. I.???On Irritable Heart; a Clinical Study of a Form of Functional Cardiac Disorder and its Consequences

Cited by 183 publications

References 0 publications

Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder

Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder

Unsteadiness of breathing in patients with hyperventilation syndrome and anxiety disorders

Neurocirculatory Asthenia, Anxiety Neurosis or the Effort Syndrome

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