Arsenic species, AS3MT amount, and AS3MT gen expression in different brain regions of mouse exposed to arsenite

Sánchez-Peña, Luz C.; Petrosyan, Pavel; Morales, Teresa; González, Nydia B.; Gutiérrez‐Ospina, Gabriel; Razo, Luz M. Del; Gonsebatt, María E.

doi:10.1016/j.envres.2010.01.007

Cited by 90 publications

(42 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arsenic can accumulate in particular brain regions, including the hippocampus (in which the dentate gyrus is located) and the frontal cortex (Sanchez-Pena et al, 2010). To demonstrate region specificity of arsenic toxicity for the dentate gyrus, we assessed histone modifications in the frontal cortex of both males and females.…”

Section: Discussionmentioning

confidence: 99%

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

Tyler

Hafez

Solomon

et al. 2015

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

Epidemiological studies report that arsenic exposure via drinking water adversely impacts cognitive development in children and, in adults, can lead to greater psychiatric disease susceptibility, among other conditions. While it is known that arsenic toxicity alters the epigenome, very few studies have investigated its effects on chromatin architecture in the brain. We have previously demonstrated that exposure to a low level of arsenic (50 ppb) during all three trimesters of fetal/neonatal development induces deficits in adult hippocampal neurogenesis in the dentate gyrus (DG), depressive-like symptoms, and alterations in gene expression in the adult mouse brain. As epigenetic processes control these outcomes, here we assess the impact of our developmental arsenic exposure (DAE) paradigm on global histone posttranslational modifications and expression of associated chromatin-modifying proteins in the dentate gyrus and frontal cortex (FC) of adult male and female mice. DAE influenced histone 3 K4 trimethylation with increased levels in the male DG and FC and decreased levels in the female DG (no change in female FC). The histone methyltransferase MLL exhibited a similar sex- and region- specific expression profile as H3K4me3 levels, while histone demethylase KDM5B expression trended in the opposite direction. DAE increased histone 3 K9 acetylation levels in the male DG along with histone acetyltransferase (HAT) expression of GCN5 and decreased H3K9ac levels in the male FC along with decreased HAT expression of GCN5 and PCAF. DAE decreased expression of histone deacetylase enzymes HDAC1 and HDAC2, which were concurrent with increased H3K9ac levels but only in the female DG. Levels of H3 and H3K9me3 were not influenced by DAE in either brain region of either sex. These findings suggest that exposure to a low, environmentally relevant level of arsenic during development induces alterations in the adult brain via histone modifications and chromatin modifiers a sex- and region-specific manner.

show abstract

Section: Discussionmentioning

confidence: 99%

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

Tyler

Hafez

Solomon

et al. 2015

Toxicology and Applied Pharmacology

View full text Add to dashboard Cite

show abstract

“…Moreover, animal studies have shown a dose-dependent accumulation of As in many parts of the brain [31,32] that play important roles in human cognition and memory. In As-exposed rodents, morphological and neurochemical changes have been noted in the hippocampus, along with expectable learning and memory deficits [33,34].…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of well water arsenic and child IQ in Maine schoolchildren

et al. 2014

View full text Add to dashboard Cite

BackgroundIn recent studies in Bangladesh and elsewhere, exposure to arsenic (As) via drinking water is negatively associated with performance-related aspects of child intelligence (e.g., Perceptual Reasoning, Working Memory) after adjustment for social factors. Because findings are not easily generalizable to the US, we examine this relation in a US population.MethodsIn 272 children in grades 3–5 from three Maine school districts, we examine associations between drinking water As (WAs) and intelligence (WISC-IV).ResultsOn average, children had resided in their current home for 7.3 years (approximately 75% of their lives). In unadjusted analyses, household well WAs is associated with decreased scores on most WISC-IV Indices. With adjustment for maternal IQ and education, HOME environment, school district and number of siblings, WAs remains significantly negatively associated with Full Scale IQ and Perceptual Reasoning, Working Memory and Verbal Comprehension scores. Compared to those with WAs < 5 μg/L, exposure to WAs ≥ 5 μg/L was associated with reductions of approximately 5–6 points in both Full Scale IQ (p < 0.01) and most Index scores (Perceptual Reasoning, Working Memory, Verbal Comprehension, all p’s < 0.05). Both maternal IQ and education were associated with lower levels of WAs, possibly reflecting behaviors (e.g., water filters, residential choice) limiting exposure. Both WAs and maternal measures were associated with school district.ConclusionsThe magnitude of the association between WAs and child IQ raises the possibility that levels of WAs ≥ 5 μg/L, levels that are not uncommon in the United States, pose a threat to child development.

show abstract

“…Recent animal studies have reported a dose-dependent accumulation of As in many parts of the brain, including cerebral cortex, thalamus, cerebellum, pons, striatum, basal ganglia, and pituitary (Sanchez-Pena et al 2010; Wang Y et al 2009). The cortex, basal ganglia, and cerebellum all play important roles in cognition, memory, language development, and control and coordination of motor function.…”

Section: Discussionmentioning

confidence: 99%

Arsenic Exposure and Motor Function among Children in Bangladesh

Parvez

Wasserman

Factor-Litvak³

et al. 2011

Environ Health Perspect

169

104

View full text Add to dashboard Cite

Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function.Methods: We investigated the associations of WAs and WMn with motor function in 304 children in Bangladesh, 8–11 years of age. We measured As and Mn concentrations in drinking water, blood, urine, and toenails. We assessed motor function with the Bruininks-Oseretsky test, version 2, in four subscales—fine manual control (FMC), manual coordination (MC), body coordination (BC), and strength and agility—which can be summarized with a total motor composite score (TMC).Results: Log-transformed blood As was associated with decreases in TMC [β = –3.63; 95% confidence interval (CI): –6.72, –0.54; p < 0.01], FMC (β = –1.68; 95% CI: –3.19, –0.18; p < 0.05), and BC (β = –1.61; 95% CI: –2.72, –0.51; p < 0.01), with adjustment for sex, school attendance, head circumference, mother’s intelligence, plasma ferritin, and blood Mn, lead, and selenium. Other measures of As exposure (WAs, urinary As, and toenail As) also were inversely associated with motor function scores, particularly TMC and BC. Square-transformed blood selenium was positively associated with TMC (β = 3.54; 95% CI: 1.10, 6.0; p < 0.01), FMC (β = 1.55; 95% CI: 0.40, 2.70; p < 0.005), and MC (β = 1.57; 95% CI: 0.60, 2.75; p < 0.005) in the unadjusted models. Mn exposure was not significantly associated with motor function.Conclusion: Our research demonstrates an adverse association of As exposure and a protective association of Se on motor function in children.

show abstract

Arsenic species, AS3MT amount, and AS3MT gen expression in different brain regions of mouse exposed to arsenite

Cited by 90 publications

References 37 publications

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain

A cross-sectional study of well water arsenic and child IQ in Maine schoolchildren

Arsenic Exposure and Motor Function among Children in Bangladesh

Contact Info

Product

Resources

About