Arsenic as the Cause of Cancer of Mucous Membrane

Goeckerman, William H.

doi:10.1001/archderm.1940.01490160101013

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1943

1977

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Cited by 10 publications

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“…It may be assumed that these localizations on the mucous membranes were also due to arsenic; several authors have made this suggestion (Ullmann, 1922;Goeckerman and Wilhelm, 1940;Montgomery, ibid., discussion;Anderson, ibid. ), 206 but it is not exactly proved; a mere coincidence cannot be excluded.…”

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confidence: 99%

Arsenical Cancer: A Review

Neubauer¹

1947

Br J Cancer

237

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confidence: 99%

Arsenical Cancer: A Review

Neubauer¹

1947

Br J Cancer

237

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“…Embryonal cells are especially sensitive to arsenic which provoked in them signs of degeneration even in concentrations of 0.25 ,tg/l. of cultivation medium (34 "colchicine-type" effect is the mechanism on which arsenic treatment of hemoblastosis was based. Clinical experience argued for the possibility that arsenic works as a carcinogen primarily in pathologically altered terrain-skin hyperkeraroses, cirrhotic liver, (vineyards) chronic bronchitis from industrial irritants, and so on.…”

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Carcinogenic, Teratogenic, and Mutagenic Effects of Arsenic

Bencko¹

1977

Environmental Health Perspectives

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This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between dinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed.The growing importance of arsenic as an environmental pollutant is demonstrated. Continuation of throughly organized epidemiological studies in regions with excessive arsenic exposure of the population and standardization of an epidemiological approach to this problem on an international basis are recommended. New approaches in experimental studies of the carcinogenicity of arsenic in combination with other known or suspected carcinogens are recommended as well.Arsenic has long been thought to contribute to the incidence of cancer. In connection with the growing number of people exposed to this substance, occupationally as well as nonoccupationally in some areas, this becomes an important problem.

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