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Cited by 27 publications
(24 citation statements)
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“…Indeed, it is 14x higher than in cardiovascular patients with normal kidney function [1]. This high rate in CKD patients cannot be explained by traditional SCD risk factors and recent clinical studies using implantable loop recorders point towards severe bradycardia and asystole as the prevailing arrhythmias causing SCD in CKD patients [2], [3]. An initial computational study from our group suggests a slowing of the cellular pacemaking rate in the human sinus node caused by reduced [Ca 2+ ] o…”
Section: Introductionmentioning
confidence: 95%
“…Indeed, it is 14x higher than in cardiovascular patients with normal kidney function [1]. This high rate in CKD patients cannot be explained by traditional SCD risk factors and recent clinical studies using implantable loop recorders point towards severe bradycardia and asystole as the prevailing arrhythmias causing SCD in CKD patients [2], [3]. An initial computational study from our group suggests a slowing of the cellular pacemaking rate in the human sinus node caused by reduced [Ca 2+ ] o…”
Section: Introductionmentioning
confidence: 95%
“…99,[123][124][125] Cardiac changes as a result of myocardial stunning, cardiac remodeling in response to cyclical pressure and volume overload, fibrotic scarring, and loss of contractile function with aberrant electrical conductivity are all pathways that conceivably increase the sudden cardiac death risk. 59,98,99,[126][127][128] These findings have similarities with the extreme physiologic demands that are experienced by healthy subjects under adverse environmental conditions, with the difference that they must be endured repeatedly by a vulnerable patient population over months and years. 129 Therefore, in order to prevent dialysis-induced organ damage, it is imperative to challenge traditional hemodialysis treatment paradigms.…”
Section: Discussionmentioning
confidence: 75%
“…However, the underlying mechanisms are not completely understood. 97,98 It is also important to note that in contrast to the general population, bradycardia leading to asystole is more frequent in hemodialysis patients. 99 Electrolyte abnormalities and cardiac structural changes likely contribute this.…”
Section: Solute Fluxesmentioning
confidence: 99%
“…Indeed, it is 14x higher than in cardiovascular patients with normal kidney function [1]. This high rate in CKD patients cannot be explained by traditional SCD risk factors and recent clinical studies using implantable loop recorders point towards severe bradycardia and asystole as the prevailing arrhythmias causing SCD in CKD patients [2], [3]. An initial computational study from our group suggests a slowing of the cellular pacemaking rate in the human sinus node caused by reduced [Ca 2+ ] o as a likely mechanism causing bradycardic SCD in CKD patients [4].…”
Section: Introductionmentioning
confidence: 99%