Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities

Phytochemical Analysis, Analgesic, Anti-Inflammatory and Anti Bacterial Activities of Berberis Lycium.

“…Methanolic extract at the dose of 200, 400 and 600mg/Kg was injected respectively in to the hind paw checked the diameter. Left for some time after extract injection and then measured the paw diameter at 1hour interval up to 4 hours and was compared with standard drugs to note the low and high potential of inflammation (Akhter et al, 2009). …”

“…The results of group 3 rd , 4 th and 5 th was compared to the group 2 nd for low or high analgesic potential. The % inhibition calculated by the following formula (Akhter et al, 2009). …”

Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity

“…Considering the proinflammatory properties of LTs and prostanoids, agents that are able to block equally the synthesis of both eicosanoids (dual inhibitors) should not only present a superior anti-inflammatory profile but also fewer side effects than NSAIDs and selective COX-2 inhibitors 39 . In continuation to our work to develop agents to treat inflammatory conditions 40,41 , we described in this article the synthesis and biological evaluation of a class of 3-(5-phenyl/phenylamino- [1,3,4]oxadiazol-2 -yl)-chromen-2-one and N- [5-(2- …”

Utilization of Cyanoacetohydrazide and Oxadiazolyl Acetonitrile in the Synthesis of Some New Cytotoxic Heterocyclic Compounds

“…The 1,3,4-oxadiazoles have been found to exhibit diverse biological activities such as antimicrobial [29][30][31][32][33], antitubercular [34], antioxidant [35], antimalarial [36], analgesic [37], anti-inflammatory [38,39], anticonvulsant [40], hypoglycemic [41] activities, as well as other biological properties such as genotoxic [42] and lipid peroxidation inhibitory activities [43]. Two examples of compounds containing the 1,3,4-oxadiazole ring used in clinical medicine are raltegravir, an antiretroviral drug [44] and zibotentan, an anticancer agent [45] (Figure 2).…”