Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials

Bradley, Rosie; Braybrooke, Jeremy; Gray, Richard; Hills, Robert Kerrin; Liu, Zulian; Pan, Hongchao; Pető, Richárd; Dodwell, David; McGale, Paul; Taylor, Carolyn; Francis, Prudence A.; Gnant, Michael; Perrone, Francesco; Regan, Meredith M.; Berry, Richard B.; Boddington, Clare; Clarke, Mike; Davies, Christina; Davies, Lucy; Duane, Fran; Evans, Vaughan; Gay, Jo; Gettins, Lucy; Godwin, Jon; James, Sam; Liu, Hui; MacKinnon, Elizabeth; Mannu, Gurdeep; McHugh, Theresa; Morris, Philip; Read, Simon; Straiton, Ewan; Jakesz, R.; Fesl, Christian; Pagani, Olivia; Gelber, Richard D.; Laurentiis, Michelino De; Placido, Sabino De; Gallo, Ciro; Albain, Kathy S.; Anderson, Stewart J.; Arriagada, R.; Bartlett, John M.S.; Bergsten-Nordström, Elizabeth; Bliss, Judith M.; Brain, Étienne; Carey, Lisa A.; Coleman, Robert E.; Cuzick, Jack; Davidson, Nancy E.; Mastro, Lucia Del; Leo, Angelo Di; Dignam, James J.; Dowsett, Mitch; Ejlertsen, Bent; Goetz, Matthew P.; Goodwin, Pam; Halpin-Murphy, Pat; Hayes, Daniel; Hill, Catherine; Jagsi, Reshma; Janni, W; Loibl, Sibylle; Mamounas, Eleftherios P.; Martín, Miguel; Mukai, Hirofumi; Nekljudova, Valentina; Norton, Larry; Ohashi, Yasuo; Pierce, Lori J.; Poortmans, Philip; Pritchard, Kathleen I.; Raina, Vinod; Rea, Daniel; Robertson, J. F. R.; Rutgers, Emiel J.; Španić, Tanja; Sparano, Joseph A.; Steger, Guenther G.; Tang, Gong; Toi, Masakazu; Tutt, Andrew N.J.; Viale, Giuseppe; Wang, Xiang; Whelan, Timothy J.; Wilcken, Nicholas; Wolmark, Norman; Cameron, David; Bergh, Jonas; Swain, Sandra M.

doi:10.1016/s1470-2045(21)00758-0

Cited by 144 publications

(75 citation statements)

References 28 publications

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“…Leukaemia is rare, and there were too few events for this excess to increase non-breast cancer mortality (RR=0.99, 95% CI 0.83-1.15). AI versus tamoxifen in premenopausal women increased mortality from cancers other than breast based on 22/3528 cancer deaths in women randomised to AI versus 11/3502 in women randomised to tamoxifen, but with no significant increase in overall non-breast-cancer mortality (RR 1.30, 95% CI 0.75-2.25) [46]. There were no reports of increased mortality from non-breast-cancer causes for other systemic therapies.…”

Section: Risks Of Non-breast-cancer Mortality and Individual Causes O...mentioning

confidence: 95%

Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality

Kerr

Dodwell

McGale

et al. 2022

Cancer Treatment Reviews

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135

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Section: Risks Of Non-breast-cancer Mortality and Individual Causes O...mentioning

confidence: 95%

Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality

Kerr

Dodwell

McGale

et al. 2022

Cancer Treatment Reviews

Self Cite

135

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“…Similarly, studies have revealed that TAX modulates p-glycoprotein mediated intestinal efflux through biphasic dose-response relationship and also danazole-mediated f-actin dynamics 25,26 . Recently, clinical studies have found that LTZ is more effective than TAX against the breast cancer and its recurrence 27,28 . Since talin is significantly involved in the breast cancer malignancy potential through cell migration and invasion 29,30 , our observation on higher talin stability with LTZ than TAX might link to its higher efficiency as a therapeutic.…”

Section: Discussionmentioning

confidence: 99%

Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

Chakraborty

Bhatt

Chowdhury

et al. 2022

Preprint

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Talin as an adhesion protein, exhibits a strong force-dependent structure-function dynamics. Being a mechanosensitive focal adhesion (FA) protein, talin might interact to several FA targeting drugs; however, the molecular mechanism of talin-drug interactions remains elusive. Here we combined magnetic tweezers and molecular dynamics (MD) simulation to explore mechanical stability of talin with three drugs based on their talin specificity. Interestingly, our study revealed that talin displays a bimodal force distribution with a low and high unfolding force population. We observed that talin nonspecific drugs (tamoxifen and letrozole) display biphasic effect: increase talin mechanical stability upto optimum concentration, followed by a decrease in stability with further concentration increase. By contrast, talin-specific cyanidin 3-O-glucoside promotes a steady increase to talin mechanical stability with its concentration. We reconciled our observation from the simulation study: tamoxifen enters into talin hydrophobic core, eventually destabilizing the protein; whereas cyanidin 3-O-glucoside stabilizes the protein core by maintaining the inter-helix distance. Finally, we observed a strong correlation among hydrophobicity and cavity analysis, illustrating a detailed mechanistic analysis of drug effect on the mechanosensitive protein. Overall this study presents a novel perspective for drug designing against mechanosensitive proteins and studying off-target effects of already known drugs.

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“…The results showed a reduced risk of BC recurrence using AIs for 5 years compared with tamoxifen in these patients. There was no significant difference between treatments for BC mortality and overall mortality [ 39 ].…”

Section: Systemic Treatmentmentioning

confidence: 99%

The History of Early Breast Cancer Treatment

Ben-Dror

Shalamov

Sonnenblick

2022

Genes

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Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials

Cited by 144 publications

References 28 publications

Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality

Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality

Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

The History of Early Breast Cancer Treatment

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