Aripiprazole versus other atypical antipsychotics for schizophrenia

Abstract

Information on all comparisons are of limited quality, are incomplete and problematic to apply clinically. Aripiprazole is an antipsychotic drug with a variant but not absent adverse effect profile. Long-term data are sparse and there is considerable scope for another update of this review as new data emerges from the many Chinese studies as well as from ongoing larger, independent pragmatic trials.

A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes

“…Participants switched to aripiprazole at 24 weeks of follow-up had better triglyceride and fasting insulin values but not for total cholesterol or LDL cholesterol. Our prolactin findings favoring aripiprazole over risperidone are consistent with those from multiepisode comparison studies 6,20 and from studies of prolactin levels following switching from risperidone to aripiprazole. 22 Our study had limitations.…”

A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes

“…Participants switched to aripiprazole at 24 weeks of follow-up had better triglyceride and fasting insulin values but not for total cholesterol or LDL cholesterol. Our prolactin findings favoring aripiprazole over risperidone are consistent with those from multiepisode comparison studies 6,20 and from studies of prolactin levels following switching from risperidone to aripiprazole. 22 Our study had limitations.…”

Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study

“…Thus, the aripiprazole group experienced less subjective well-being and aripiprazole was also found to cause nausea and dizziness more frequently. Aripiprazole has been reported to give more nausea compared to several other atypical antipsychotics, but this was found in long-term treatment of patients (Khanna et al, 2013). Our finding may suggest that this effect is also apparent upon acute administration.…”

Quetiapine versus aripiprazole in the management of schizophrenia

“…Khanna and colleagues in a comparison between aripiprazole and other Second Generation Antipsychotics (SGAs) did not find any important difference between aripiprazole and olanzapine with respect to global mental state and extrapyramidal symptoms, although they found fewer increases in cholesterol levels and weight gain for aripiprazole. This finding could also be valid in comparing aripiprazole with risperidone and ziprasidone when considering the global mental state of the treated patients [Khanna et al 2013].…”

A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes

“…Participants switched to aripiprazole at 24 weeks of follow-up had better triglyceride and fasting insulin values but not for total cholesterol or LDL cholesterol. Our prolactin findings favoring aripiprazole over risperidone are consistent with those from multiepisode comparison studies 6,20 and from studies of prolactin levels following switching from risperidone to aripiprazole. 22 Our study had limitations.…”

Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study

“…Thus, the aripiprazole group experienced less subjective well-being and aripiprazole was also found to cause nausea and dizziness more frequently. Aripiprazole has been reported to give more nausea compared to several other atypical antipsychotics, but this was found in long-term treatment of patients (Khanna et al, 2013). Our finding may suggest that this effect is also apparent upon acute administration.…”

Quetiapine versus aripiprazole in the management of schizophrenia

“…Khanna and colleagues in a comparison between aripiprazole and other Second Generation Antipsychotics (SGAs) did not find any important difference between aripiprazole and olanzapine with respect to global mental state and extrapyramidal symptoms, although they found fewer increases in cholesterol levels and weight gain for aripiprazole. This finding could also be valid in comparing aripiprazole with risperidone and ziprasidone when considering the global mental state of the treated patients [Khanna et al 2013].…”

A Randomized Comparison of Aripiprazole and Risperidone for the Acute Treatment of First-Episode Schizophrenia and Related Disorders: 3-Month Outcomes

“…Participants switched to aripiprazole at 24 weeks of follow-up had better triglyceride and fasting insulin values but not for total cholesterol or LDL cholesterol. Our prolactin findings favoring aripiprazole over risperidone are consistent with those from multiepisode comparison studies 6,20 and from studies of prolactin levels following switching from risperidone to aripiprazole. 22 Our study had limitations.…”

Effects of haloperidol and aripiprazole on the human mesolimbic motivational system: A pharmacological fMRI study

“…Thus, the aripiprazole group experienced less subjective well-being and aripiprazole was also found to cause nausea and dizziness more frequently. Aripiprazole has been reported to give more nausea compared to several other atypical antipsychotics, but this was found in long-term treatment of patients (Khanna et al, 2013). Our finding may suggest that this effect is also apparent upon acute administration.…”

Quetiapine versus aripiprazole in the management of schizophrenia

“…Khanna and colleagues in a comparison between aripiprazole and other Second Generation Antipsychotics (SGAs) did not find any important difference between aripiprazole and olanzapine with respect to global mental state and extrapyramidal symptoms, although they found fewer increases in cholesterol levels and weight gain for aripiprazole. This finding could also be valid in comparing aripiprazole with risperidone and ziprasidone when considering the global mental state of the treated patients [Khanna et al 2013].…”