Aripiprazole for autism spectrum disorders (ASD)

Abstract

Analysis 1.12. Comparison 1 Aripiprazole versus placebo in randomised controlled trials (RCTs), Outcome 12 Body mass index (BMI) change from baseline (side e ect

A retrospective cohort study of prescription drug use among youth with intellectual/developmental disabilities in British Columbia

“…These findings align with previous research that have found high levels of antipsychotic and other psychotropic prescriptions for adults with IDD (Nøttestad & Linaker 2003;de Kuijper et al 2010;Deb et al 2023) and for children with autism (Logan et al 2012). This raises potential concerns of side effects such as over-sedation and decreased cognition (Zetsen et al 2022), weight gain (Hirsch & Pringsheim 2016) and potentially injurious falls (Díaz-Gutiérrez et al 2017). The adjusted odds of use of multiple types of psychotropic medications in one year were also greater in the study population with IDD compared with the population without IDD.…”

A retrospective cohort study of prescription drug use among youth with intellectual/developmental disabilities in British Columbia

“…These findings align with previous research that have found high levels of antipsychotic and other psychotropic prescriptions for adults with IDD (Nøttestad & Linaker 2003;de Kuijper et al 2010;Deb et al 2023) and for children with autism (Logan et al 2012). This raises potential concerns of side effects such as over-sedation and decreased cognition (Zetsen et al 2022), weight gain (Hirsch & Pringsheim 2016) and potentially injurious falls (Díaz-Gutiérrez et al 2017). The adjusted odds of use of multiple types of psychotropic medications in one year were also greater in the study population with IDD compared with the population without IDD.…”

The Pharmacoepidemiology of Psychotropic Medication Use in Canadian Children from 2012 to 2016

“…We used counts, percentages, and rates (per 1000 person-years) along with percent change to summarize the raw frequencies of written prescriptions and reasons for these, with data presented in figures and tables. Trends observed with calculated recommendation rates followed similar trends to that of the recommendation counts as the Canadian population aged 18 and younger did not change between and 2016(Statistics Canada 2018. The population size of children and youth in 2010 was 7,401,861, increasing only 0.34% to 7,426,926 by 2016.…”

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

“…Discontinuation and/or dose reduction of other medications, as we observed in a considerable number of cases in this work, may significantly reduce the patient’s array of side effects associated to other medicines ( 26 , 27 , 30 , 34 , 35 , 38 , 41 , 42 , 44 – 46 , 127 , 129 – 135 , 139 ). Furthermore, in the long run, such a wide range of benefits may also significantly alleviate the family’s economic burden ( 22 ).…”

A retrospective cohort study of prescription drug use among youth with intellectual/developmental disabilities in British Columbia

“…These findings align with previous research that have found high levels of antipsychotic and other psychotropic prescriptions for adults with IDD (Nøttestad & Linaker 2003;de Kuijper et al 2010;Deb et al 2023) and for children with autism (Logan et al 2012). This raises potential concerns of side effects such as over-sedation and decreased cognition (Zetsen et al 2022), weight gain (Hirsch & Pringsheim 2016) and potentially injurious falls (Díaz-Gutiérrez et al 2017). The adjusted odds of use of multiple types of psychotropic medications in one year were also greater in the study population with IDD compared with the population without IDD.…”

The Pharmacoepidemiology of Psychotropic Medication Use in Canadian Children from 2012 to 2016

“…We used counts, percentages, and rates (per 1000 person-years) along with percent change to summarize the raw frequencies of written prescriptions and reasons for these, with data presented in figures and tables. Trends observed with calculated recommendation rates followed similar trends to that of the recommendation counts as the Canadian population aged 18 and younger did not change between and 2016(Statistics Canada 2018. The population size of children and youth in 2010 was 7,401,861, increasing only 0.34% to 7,426,926 by 2016.…”

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

“…Discontinuation and/or dose reduction of other medications, as we observed in a considerable number of cases in this work, may significantly reduce the patient’s array of side effects associated to other medicines ( 26 , 27 , 30 , 34 , 35 , 38 , 41 , 42 , 44 – 46 , 127 , 129 – 135 , 139 ). Furthermore, in the long run, such a wide range of benefits may also significantly alleviate the family’s economic burden ( 22 ).…”

A retrospective cohort study of prescription drug use among youth with intellectual/developmental disabilities in British Columbia

“…These findings align with previous research that have found high levels of antipsychotic and other psychotropic prescriptions for adults with IDD (Nøttestad & Linaker 2003;de Kuijper et al 2010;Deb et al 2023) and for children with autism (Logan et al 2012). This raises potential concerns of side effects such as over-sedation and decreased cognition (Zetsen et al 2022), weight gain (Hirsch & Pringsheim 2016) and potentially injurious falls (Díaz-Gutiérrez et al 2017). The adjusted odds of use of multiple types of psychotropic medications in one year were also greater in the study population with IDD compared with the population without IDD.…”

The Pharmacoepidemiology of Psychotropic Medication Use in Canadian Children from 2012 to 2016

“…We used counts, percentages, and rates (per 1000 person-years) along with percent change to summarize the raw frequencies of written prescriptions and reasons for these, with data presented in figures and tables. Trends observed with calculated recommendation rates followed similar trends to that of the recommendation counts as the Canadian population aged 18 and younger did not change between and 2016(Statistics Canada 2018. The population size of children and youth in 2010 was 7,401,861, increasing only 0.34% to 7,426,926 by 2016.…”

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

“…Discontinuation and/or dose reduction of other medications, as we observed in a considerable number of cases in this work, may significantly reduce the patient’s array of side effects associated to other medicines ( 26 , 27 , 30 , 34 , 35 , 38 , 41 , 42 , 44 – 46 , 127 , 129 – 135 , 139 ). Furthermore, in the long run, such a wide range of benefits may also significantly alleviate the family’s economic burden ( 22 ).…”