Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes

Transcriptional Network Controlling Endochondral Ossification

“…[24] Our group also found that Arid5b recruits the histone demethylase Phf2 to Sox9 target genes and epigenetically regulates chondrogenesis. [26] Hattori et al [27] identified Tat interactive protein-60 (Tip60) as a coactivator of Sox9 via yeast two-hybrid screening. [27] In addition to these molecules, β-catenin,[28] cAMP response element-binding protein (CREB)-binding protein (CBP)/p300,[29] thyroid hormone receptor-associated protein 230 (Trap230),[30] WW domain containing E3 ubiquitin protein ligase 2 (wwp2),[31] and PPARγ coactivator-1 (PGC-1α) [32] have been identified as Sox9-associated proteins.…”

The transcription factor Foxc1 is necessary for Ihh–Gli2-regulated endochondral ossification

“…Thus, the identification and characterization of novel transcription factors involved in these processes will contribute to a better understanding of endochondral ossification. Numerous attempts have been made to identify these and we previously identified several transcription factors using a high-throughput assay system [21][22][23][24] and Solexa deep-sequencing technology 25 . However, the transcriptional networks of endochondral ossification are still not fully elucidated.…”

Regulation of transcriptional network system during bone and cartilage development

“…Gene profiling by microarray and RNA-Seq experiments have showed that WWP2 and ARID5B are also required for the SOX9-regulated chondrogenesis (Fig. 3) [73][74][75]. In addition, Tip60 appears to play a role in endochondral ossification through the association of chromatin with SOX9 (Fig.…”