Argon plasma treatment-induced grafting of acrylic acid onto expanded poly(tetrafluoroethylene) membranes

Hidzir, Norsyahidah Mohd; Hill, David J. T.; Taran, Elena; Martin, Darren J.; Grøndahl, Lisbeth

doi:10.1016/j.polymer.2013.10.003

Cited by 32 publications

(29 citation statements)

References 48 publications

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“…For the ammonia plasma treatment the conditions have previously been optimised and have been reported not to cause surface etching of PTFE [18]. In contrast to a previous report [19], deposition of a plasma polymer coating did not occlude the pores. It was important to characterise the as-received ePTFE membranes (UT-ePTFE_M).…”

Section: Discussionmentioning

confidence: 99%

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry

Kearns

Tasker

Zhuola

et al. 2017

J Mater Sci: Mater Med

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Subretinal transplantation of functioning retinal pigment epithelial (RPE) cells may have the potential to preserve or restore vision in patients affected by blinding diseases such as age-related macular degeneration (AMD). One of the critical steps in achieving this is the ability to grow a functioning retinal pigment epithelium, which may need a substrate on which to grow and to aid transplantation. Tailoring the physical and chemical properties of the substrate should help the engineered tissue to function in the long term. The purpose of the study was to determine whether a functioning monolayer of RPE cells could be produced on expanded polytetrafluoroethylene substrates modified by either an ammonia plasma treatment or an n-Heptylamine coating, and whether the difference in surface chemistries altered the extracellular matrix the cells produced. Primary human RPE cells were able to form a functional, cobblestone monolayer on both substrates, but the formation of an extracellular matrix to exhibit a network structure took months, whereas on non-porous substrates with the same surface chemistry, a similar appearance was observed after a few weeks. This study suggests that the surface chemistry of these materials may not be the most critical factor in the development of growth of a functional monolayer of RPE cells as long as the cells can attach and proliferate on the surface. This has important implications in the design of strategies to optimise the clinical outcomes of subretinal transplant procedures.Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry

Kearns

Tasker

Zhuola

et al. 2017

J Mater Sci: Mater Med

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“…The sample treated at ±5.0 kVp-p was appeared to have an intensively burnt area, so it was presumed to lead to heavy etching reactions. In a recent related report of the argon plasma treatment to other fluoropolymers, Hidzir et al [25] described that the chemical environment of the surface of expanded poly (tetrafluoroethylene), which was treated with 100 W argon plasma under the low pressure and subsequently exposed to air changed substantially, displayed evidence of defluorination (F/C atom ratio of 1.9 from 2.4). On the other hand, oxidation reactions progressed 23, 31 and 54% for 60, 180 and 300 s, respectively, compared with an untreated PVDF membrane.…”

Section: Structure Characterization Of the Membranes By Xps Analysismentioning

confidence: 99%

Preparation and characterization of Protein A-immobilized PVDF and PES membranes

Akashi¹,

Kuroda²

2015

Express Polym. Lett.

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“…An additional complexity of using these monomers in graft polymerization reactions is the instability of the ester bonds during polymerization and detailed analysis of the graft copolymers (as well as soluble polymers produced by RAFT mediated polymerization) revealed that the MOEP graft copolymer is best described as MOEP‐co‐HEMA while the MAEP graft copolymers are MAEP‐co‐AA . More recent work has involved grafting of AA either by simultaneous gamma irradiation or the peroxy/hydroxyl method using Ar plasma pretreatment . These works have extensively investigated the impact of the grafting process on the mechanical properties of ePTFE and concluded that the tensile properties of AA grafted ePTFE tested under “wet” conditions were reduced to a larger extent for membranes exposed to gamma irradiation grafting compared to that obtained by plasma induced grafting and the latter is thus a preferred technique for surface modification of ePTFE used in medical applications.…”

Section: Modification Of Eptfementioning

confidence: 99%

Enhancing expanded poly(tetrafluoroethylene) (ePTFE) for biomaterials applications

Cassady

Hidzir

Grøndahl

2014

J of Applied Polymer Sci

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Poly(tetrafluoroethylene) (PTFE), a fully fluorinated linear thermoplastic polymer, and in particular the porous form expanded PTFE (ePTFE) has found widespread use in biomaterials application due to its properties of high toughness, nonadhesiveness and hydrophobicity. While it performs ideally for many applications, some challenges have been identified for its use in small diameter vascular grafts and as a tissue space-filler for cosmetic reconstructions where the implant interfaces with bone. For these applications modification of the surface of ePTFE has been investigated as a means to enhance its performance. This review will focus on the applications listed above and will detail methods of evaluating the biological response, methods used to enhance the surface properties of ePTFE, and how the modified materials have performed in their intended applications. This review will focus on work published from 2004 onwards.

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Argon plasma treatment-induced grafting of acrylic acid onto expanded poly(tetrafluoroethylene) membranes

Cited by 32 publications

References 48 publications

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry

Preparation and characterization of Protein A-immobilized PVDF and PES membranes

Enhancing expanded poly(tetrafluoroethylene) (ePTFE) for biomaterials applications

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